A5079690554- Congenital Heart Disease Studies
- Prenatal Screening and Diagnostics
- Congenital Diaphragmatic Hernia Studies
- Pregnancy and preeclampsia studies
- Cardiovascular Issues in Pregnancy
- Congenital Anomalies and Fetal Surgery
- Assisted Reproductive Technology and Twin Pregnancy
- Fetal and Pediatric Neurological Disorders
- Cardiac Arrhythmias and Treatments
- Neonatal Respiratory Health Research
- Birth, Development, and Health
- Parvovirus B19 Infection Studies
- Urological Disorders and Treatments
- Tracheal and airway disorders
- Pediatric Urology and Nephrology Studies
- Maternal and fetal healthcare
- Cardiac Structural Anomalies and Repair
- Blood groups and transfusion
- Cardiac Valve Diseases and Treatments
- Gestational Diabetes Research and Management
- Vascular anomalies and interventions
- Medical and Health Sciences Research
- Cardiovascular Function and Risk Factors
- Renal and related cancers
- Congenital heart defects research
University Hospital Bonn
2016-2025
University of Bonn
2014-2023
Klinik für Frauenheilkunde
2008-2023
Universitätsklinik für Frauenheilkunde und Geburtshilfe
2004-2022
Copenhagen University Hospital
2020
Rigshospitalet
2020
Universitäts-Augenklinik Bonn
1989-2019
University Hospital Cologne
2018
Nationwide Children's Hospital
2017
Medical University of Warsaw
2017
To evaluate the distribution of Doppler pulsatility index (PI) measurements umbilical and middle cerebral arteries in singleton fetuses women with normal uterine artery blood flow to construct reference ranges for cerebroplacental PI ratio.The was determined mid-portion mid- or distal segment 306 fetuses. The ratio (CPR) from paired measurements. After determination best fit, were constructed each parameter against gestational age (GA).The had a linear relationship GA (umbilical = - 0.0246 x...
In Brief OBJECTIVE: To identify specific estimates and predictors of neonatal morbidity mortality in early onset fetal growth restriction due to placental dysfunction. METHODS: Prospective multicenter study prenataly diagnosed growth-restricted liveborn neonates less than 33 weeks gestational age. Relationships between perinatal variables (arterial venous Dopplers, age, birth weight, acid-base status, Apgar scores) major complications, death, intact survival were analyzed by logistic...
Abstract Objective To test the hypothesis that hemodynamic changes depicted by Doppler precede deteriorating biophysical profile score in severe intrauterine growth restriction. Methods Intrauterine growth‐restricted fetuses with elevated umbilical artery pulsatility index (PI) > 2 standard deviations above mean for gestational age and birth weight < 10th centile were examined longitudinally. Fetal well‐being was assessed serially five‐component scoring (tone, movement, breathing,...
Abstract Objective To identify the sequence of progression arterial and venous Doppler abnormalities from onset placental insufficiency in intrauterine growth restriction (IUGR). Methods Prospective observational study singletons with IUGR (abdominal circumference < 5 th percentile) who underwent serial standardized umbilical artery (UA), middle cerebral (MCA), ductus venosus (DV) vein (UV) surveillance. Time intervals between progressive patterns deterioration were related to UA status...
Abstract Objective The aim of this investigation was to assess the relationship between abnormal arterial and venous Doppler findings perinatal outcome in fetuses with intrauterine growth restriction (IUGR). Methods velocimetry umbilical artery (UA), middle cerebral (MCA), inferior vena cava (IVC), ductus venosus (DV) free vein performed 121 IUGR a UA pulsatility index (PI) > 2SD above gestational age mean subsequent birth weight < 10th centile for age. Groups based on last exam were:...
Our aim was to test the hypothesis that qualitative ductus venosus and umbilical venous Doppler analysis improves prediction of critical perinatal outcomes in preterm growth-restricted fetuses with abnormal placental function.Patients suspected intrauterine growth restriction (IUGR) underwent uniform fetal assessment including artery (UA), (DV) vein (UV) Doppler. Absent or reversed UA end-diastolic velocity (UA-AREDV), absence reversal atrial systolic blood flow DV (DV-RAV) pulsatile (P-UV)...
Abstract From 1981 to 1990, 60 fetuses with tachyarrhythmia (21–39 weeks of gestation) were treated in utero . Of these, 54 cases supraventricular tachycardia, and six atrial flutter. Non‐immune fetal hydrops was present 21 tachycardia five flutter, a total 26 cases. Transplacental treatment by maternally administered antiarrhythmic drugs (digoxin only or combination verapamil) produced good results non‐hydropic fetuses. In this group, all 34 survived. hydrops, 20 out 13 the direct therapy...
Fetal echocardiography was performed using a high-frequency vaginal ultrasound probe in 114 singleton pregnancies between 11 and 16 weeks of gestation. The four-chamber view with both atria, atrioventricular valves ventricles as well the origin double-crossing aorta pulmonary trunk could always be demonstrated from 13th week onwards. In 12 13 cases, cardiac malformations were diagnosed first trimester. Only one case transabdominal necessary at 20 to make diagnosis. several however,...
Abstract Objective To investigate the performance of non‐stress test (NST), computerized fetal heart rate analysis (cCTG), biophysical profile scoring (BPS) and arterial venous Doppler ultrasound investigation in prediction acid–base status growth restriction. Methods Growth‐restricted fetuses, defined by abdominal circumference < 5 th percentile umbilical artery (UA) pulsatility index > 95 percentile, were tested NST, cCTG, BPS, UA, middle cerebral (MCA), ductus venosus (DV) vein (UV)...
Abstract Objective Multi‐vessel Doppler ultrasonography and biophysical profile scoring (BPS) are used in the surveillance of growth restricted fetuses (IUGR). The interpretation both tests performed concurrently may be complex. This study examines relationship between test results IUGR fetuses. Methods Three hundred twenty‐eight (abdominal circumference < 5th percentile, elevated umbilical artery (UA) pulsatility index (PI)) had concurrent with UA, middle cerebral (MCA) ductus venosus...
Abstract Objective To evaluate the conditions associated with absent ductus venosus (ADV) diagnosed by prenatal ultrasonography. Methods Retrospective review of 23 cases ADV in two tertiary referral centers a general screening policy concerning Doppler assessment venosus. The results are discussed together 63 from literature. Results In 19 fetuses umbilical vein connected to portal sinus, while remaining four had extrahepatic venous drainage. Associated anomalies were present 15 out fetuses:...
<i>Objective:</i> The current operative approach for fetal repair of spina bifida aperta requires maternal laparotomy and hysterotomy. Following technical feasibility studies in sheep, we performed percutaneous fetoscopic patch coverage this lesion 3 human fetuses between 23 + 4 25 weeks gestation. <i>Methods Results:</i> Whereas the detached first case after procedure, it covered exposed neural tissue 2 other beyond their delivery. Two three children survived, but 1...
To study if the duration of individual Doppler abnormalities is an independent predictor adverse outcome in fetal growth restriction (FGR) caused by placental dysfunction.This was a secondary analysis patients with FGR (abdominal circumference < 5(th) percentile and umbilical artery (UA) pulsatility index (PI) elevation) who had at least three examinations before delivery. Days absent/reversed UA end-diastolic velocity (UA-AREDV), low middle cerebral PI (brain sparing), ductus venosus (DV)...
A team of experts from the fields gynaecology and obstetrics, diabetology, internal medicine, paediatrics midwifery Germany, Austria Switzerland produced a new version existing S3 guideline on gestational diabetes. It replaces recommendations German Association for Gynaecology Obstetrics Diabetes diagnosis treatment diabetes 2011 is valid three German-speaking countries. The primary aim to improve standardise prevention, screening, diagnosis, follow-up through evidence-based outpatient...
Objective To describe antenatal findings and evaluate prenatal risk parameters for adverse outcome or need intervention in fetuses with congenital pulmonary airway malformation (CPAM). Methods In our retrospective study all a diagnosis of CPAM detected tertiary referral center between 2002 2013 were analyzed. Sonographic noted measurements mass-to-thorax-ratio (MTR), volume-ratio (CVR) observed to expected lung-to head-ratio (o/e LHR) conducted correlated fetal neonatal morbidity mortality...
First-trimester screening between 11 + 0 and 13 6 weeks with qualified prenatal counseling, detailed ultrasound, biochemical markers maternal factors has become the basis for decisions about further examinations. It detects numerous structural genetic anomalies. The inclusion of uterine artery Doppler PlGF screens preeclampsia fetal growth restriction. Low-dose aspirin significantly reduces prevalence severe preterm eclampsia. Cut-off values define groups high, intermediate low probability....
The aim of this official guideline published and coordinated by the German Society Gynecology Obstetrics (DGGG) was to provide consensus-based recommendations obtained evaluating relevant literature for diagnostic treatment management women with fetal growth restriction.
Abstract Introduction The emergence of handheld ultrasound devices capable connecting to cell phones or tablets heralds a significant advancement in medical technology, particularly within the field obstetrics. These offer promise immediate bedside examinations, potentially revolutionizing patient care by enabling fetal assessments diverse settings. Material and Methods This prospective study aimed validate reliability non‐piezo, chip‐based clinical obstetric practice. Conducted university...