A5014917429- Assisted Reproductive Technology and Twin Pregnancy
- Prenatal Screening and Diagnostics
- Fetal and Pediatric Neurological Disorders
- Spinal Dysraphism and Malformations
- Pregnancy and preeclampsia studies
- Congenital Heart Disease Studies
- Congenital Diaphragmatic Hernia Studies
- Blood groups and transfusion
- Cerebrospinal fluid and hydrocephalus
- Neonatal and fetal brain pathology
- Cardiovascular Issues in Pregnancy
- Ectopic Pregnancy Diagnosis and Management
- Blood transfusion and management
- Maternal and Perinatal Health Interventions
- Hemoglobinopathies and Related Disorders
- Neonatal Respiratory Health Research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Teratomas and Epidermoid Cysts
- Cardiac Structural Anomalies and Repair
- Birth, Development, and Health
- Erythrocyte Function and Pathophysiology
- Neonatal Health and Biochemistry
- Streptococcal Infections and Treatments
- Urological Disorders and Treatments
- Neonatal and Maternal Infections
University of Pittsburgh
2015-2024
Magee-Womens Hospital
2014-2024
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2016-2024
National Heart Lung and Blood Institute
2024
Leiden University Medical Center
2024
University of California Davis Medical Center
2022
Albany Medical Center Hospital
2022
Johns Hopkins University
2022
University of Pittsburgh Medical Center
2010-2021
Magee-Womens Research Institute
2007-2020
In early-onset severe hemolytic disease of the fetus and newborn (HDFN), transplacental transfer maternal antierythrocyte IgG alloantibodies causes fetal anemia that leads to use high-risk intrauterine transfusions in order avoid hydrops death. Nipocalimab, an anti-neonatal Fc receptor blocker, inhibits lowers levels.
JFW reports serving as a consultant in medico-legal cases related to kernicterus and for Mallinckrodt Pharmaceuticals. The other authors have no conflicts of interest disclose.
After the transfusion of RhD-positive red blood cell (RBC)-containing products to an RhD-negative woman childbearing potential (WCP) during trauma resuscitation, there are several events that must occur for WCP have a future pregnancy affected by hemolytic disease fetus and newborn (HDFN). This study identified quantitated frequency novel event in sequence from resuscitation HDFN outcome, is, development high titer anti-D among women who were D-alloimmunized.
In Brief Because they share a common placenta, monochorionic gestations are subject to unique pregnancy complications that can threaten the life and health of both fetuses therefore impose disproportionate disease burden on overall perinatal morbidity mortality. Early detection these processes may allow for prompt referral regional treatment center, comprehensive counseling, better patient outcomes. The North American Fetal Therapy Network is consortium 30 medical institutions in United...
Fetal therapies undertaken to improve fetal outcome or optimize transition neonate life often entail some level of maternal, fetal, neonatal risk. A therapy center needs access resources carry out such and manage complications that might arise, either related the per se as part underlying maternal condition. Accordingly, a requires dedicated operational infrastructure necessary allow for appropriate oversight monitoring clinical performance facilitate multidisciplinary collaboration between...
<b><i>Introduction:</i></b> A critical component of an evidence-based reassessment in-utero intervention for fetal aqueductal stenosis (fetal AS) is determining if the prenatal diagnosis can be accurately made at a gestational age amenable to intervention. <b><i>Methods:</i></b> multicenter, prospective, observational study was conducted through North American Fetal Therapy Network (NAFTNet). Pregnancies complicated by severe central nervous...
BACKGROUND Red blood cell (RBC) antigen matching policies to prevent alloimmunization in females of childbearing potential (FCP) vary between centers. To inform transfusion centers responsible for making decisions about FCPs, the causal stimulus antibodies implicated severe hemolytic disease fetus and newborn (HDFN) must be determined. STUDY DESIGN AND METHODS We conducted a multinational retrospective study women with offspring affected by HDFN requiring neonatal exchange and/or...
In Brief Owing to vascular connections within a single placenta, monochorionic gestations present distinctive prenatal management challenges. Complications that can arise as result of unbalanced hemodynamic exchange (twin–twin transfusion syndrome and twin anemia polycythemia sequence) unequal placental sharing (selective fetal growth restriction) should be kept in mind while is being planned. Because unique angioarchitecture, what happens one directly affect the other. Death death or...
A risk assessment model for predicting the of haemolytic disease fetus and newborn (HDFN) in future pregnancies following transfusion Rh(D)-positive red blood cell (RBC)-containing products to females childbearing potential (FCP) was developed, accounting age that FCP is transfused various countries.The HDFN prediction included inputs: death trauma, Rh(D) alloimmunization rate RBC transfusion, expected number live births resuscitation, probability carrying an fetus, carried by alloimmunized...
<h3>Importance</h3> Hypertensive disorders of pregnancy are associated with future cardiovascular disease, perhaps because subclinical cardiac dysfunction before leading to impaired adaptation pregnancy. Natriuretic peptides promising biomarkers for detecting outside <h3>Objective</h3> To investigate whether higher concentrations N-terminal pro–brain natriuretic peptide (NT-proBNP) in early would be hypertensive and hypertension 2 7 years post partum. <h3>Design, Setting, Participants</h3>...
<b><i>Introduction:</i></b> Fetal care centers (FCCs) in the USA lack a standardized instrument to measure person-centered care. This study aimed develop and validate Person-Centered Care Centers (PCC-FCC) Scale. <b><i>Methods:</i></b> Initial items were developed based on literature input from clinicians former patients. A Delphi involving 16 experts was conducted content construct. Through three rounds of online questionnaires using...
OBJECTIVE: To assess the association between mode of delivery and 2-year motor function in children with prenatal diagnosis myelomeningocele. METHODS: A multisite retrospective cohort study myelomeningocele across 14 NAFTNet (North American Fetal Therapy Network) centers born 2007 2020 who had a physical examination available at 2 years life. Exclusion criteria were utero repair, postnatal diagnosis, missing data on fetal presentation delivery, contraindications to labor. The primary outcome...
In Brief OBJECTIVE: To determine the current maternal and fetal selection criteria operative approaches used at centers performing myelomeningocele surgery. METHODS: The 17 principal investigators participating in Fetal Myelomeningocele Consortium were asked to participate an anonymous online survey regarding practice of maternal–fetal surgery for neural tube defect repair results tabulated. 35-question related diagnostic testing, inclusion exclusion criteria, clinical management. RESULTS:...
We performed karyotype and array comparative genomic hybridization (aCGH) analyses on 177 prenatal samples, including 162 (92%) samples from fetuses with sonographic anomalies. Overall 12 (6.8%) had abnormal 42 (23.7%) microarray results: 20 (11.3%) pathogenic copy number variations (CNVs), 16 CNVs of uncertain clinical significance, 4 establishing carrier status for recessive, X-linked, or susceptibility to late onset dominant disease, two pseudomosaicism due in vitro cultural artifacts....
Abstract Objective The objective of this article is to determine the success rate prenatally diagnosed isolated aqueductal stenosis (AS) as a first step in an evidence‐based reassessment ventriculoamniotic shunting for AS. Methods Cases ventriculomegaly at Magee‐Womens Hospital between 2006 and 2013 were ascertained. AS was suspected when prenatal ultrasound magnetic resonance imaging (MRI) demonstrated signs pressure hydrocephalus. diagnosis generated by MRI compared with postnatal based...