A5029796323- Blood groups and transfusion
- Prenatal Screening and Diagnostics
- Assisted Reproductive Technology and Twin Pregnancy
- Platelet Disorders and Treatments
- Pregnancy and preeclampsia studies
- Reproductive System and Pregnancy
- Neonatal Health and Biochemistry
- Hemoglobinopathies and Related Disorders
- Immunodeficiency and Autoimmune Disorders
- Parvovirus B19 Infection Studies
- Blood disorders and treatments
- Erythrocyte Function and Pathophysiology
- Hematopoietic Stem Cell Transplantation
- Immune Cell Function and Interaction
- Ectopic Pregnancy Diagnosis and Management
- Fetal and Pediatric Neurological Disorders
- Cell Adhesion Molecules Research
- Infant Nutrition and Health
- Pediatric Hepatobiliary Diseases and Treatments
- Congenital Anomalies and Fetal Surgery
- Organ and Tissue Transplantation Research
- T-cell and B-cell Immunology
- Ethics in Clinical Research
- Spinal Dysraphism and Malformations
- Abdominal Trauma and Injuries
Karolinska Institutet
2013-2025
Umeå University
2024-2025
Leiden University Medical Center
2024
Karolinska University Hospital
2013-2023
IFC Research (United Kingdom)
2018
Canadian Blood Services
2018
Universitat de Barcelona
2017
Centre for Biomedical Network Research on Rare Diseases
2017
Training Programs in Epidemiology and Public Health Interventions Network
2011
Children's Hospital of Philadelphia
2007-2010
In early-onset severe hemolytic disease of the fetus and newborn (HDFN), transplacental transfer maternal antierythrocyte IgG alloantibodies causes fetal anemia that leads to use high-risk intrauterine transfusions in order avoid hydrops death. Nipocalimab, an anti-neonatal Fc receptor blocker, inhibits lowers levels.
To develop a simple and robust assay suitable for fetal RHD screening in first-trimester pregnancy to estimate the sensitivity specificity of test after its implementation an unselected pregnant population.Pregnant women attending their first antenatal visit were included, determination was performed all who typed RhD-negative by routine serology. DNA extracted automated system quantitative polymerase chain reaction done based on exon 4. Reporting criteria strict.Four thousand one hundred...
<i>Introduction:</i> We present a review of all cases intravascular transfusions in red cell alloimmunization over time span 20 years Stockholm. The aim the study is to compare our results with published from larger centers and identify areas that can be further improved. <i>Material Methods:</i> A retrospective cohort was conducted women treated intrauterine due erythrocyte immunization hospital between June 1990 2010. Primary outcome variables were fetal neonatal...
The lack of fetal immune responses to foreign antigens, i.e., immunologic tolerance, is the most compelling rationale for prenatal stem cell and gene therapy. However, frequency engraftment following in utero hematopoietic transplantation (IUHCT) murine model reduced allogeneic, compared with congenic, recipients. This observation supports existence an barrier challenges classic assumptions tolerance. Here, we present evidence that presence adaptive response recipients IUHCT failed maintain...
Objective To estimate the incidence of RhD immunisation after implementation first trimester non-invasive fetal RHD screening to select only negative women carrying positive fetuses for routine antenatal anti-D prophylaxis (RAADP). Materials and Methods We present a population-based prospective observational cohort study with historic controls including all maternity care centres delivery hospitals in Stockholm region, Sweden. All pregnant were screened genotype pregnancy. Anti-D...
ABSTRACT Objective To investigate the antenatal management and outcome in a large international cohort of monochorionic twin pregnancies with spontaneous or post‐laser anemia–polycythemia sequence (TAPS). Methods This study analyzed data diagnosed antenatally TAPS 17 fetal therapy centers, recorded Registry between 2014 2019. Antenatal diagnosis was based on middle cerebral artery peak systolic velocity > 1.5 multiples median (MoM) donor < 1.0 MoM recipient. The following groups were...
During pregnancy, the maternal immune system must tolerate developing foetus, and yet retain a potent antimicrobial response to prevent infections. Mucosal associated invariant T (MAIT) cells recognize microbial-derived vitamin B metabolites presented on MR1 molecule, but their presence function at foetal-maternal interface is not known. We here isolated mononuclear from paired samples of peripheral blood (PB), intervillous (IVB), decidua parietalis (DP) following uncomplicated term...
The maternal part of the placenta, decidua, consists immune cells, decidual stromal and extravillous fetal trophoblasts. In a successful pregnancy, these cell compartments interact to provide an intricate balance between tolerance antimicrobial defense. These processes are still poorly characterized in two anatomically different tissues, basalis parietalis. We examined cells from decidua parietalis term placentas (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
BackgroundTwin anemia polycythemia sequence is a chronic form of unbalanced fetofetal transfusion through minuscule placental anastomoses in monochorionic twins, leading to the donor and recipient. Owing low incidence twin sequence, data on diagnosis, management, outcome are limited.ObjectiveThis study aimed investigate large international cohort spontaneous sequence.Study DesignData from registry, retrospectively collected between 2014 2019, were used for this study. A total 17 fetal...
Importance Preventive efforts in pregnancy-related alloimmunization have considerably decreased the prevalence of hemolytic disease fetus and newborn (HDFN). International studies are therefore essential to obtain a deeper understanding postnatal management outcomes HDFN. Taken together with numerous treatment options, large practice variations among centers may exist. Objectives To assess HDFN international identify opportunities improve care. Design, Setting, Participants In this...
(Abstracted from N Engl J Med 2024;391:526–537) Severe hemolytic disease of the fetus and newborn (HDFN) is result a transplacental transfer maternal IgG alloantibodies, which can cause fetal anemia. Early-onset severe HDFN occurs at ≤24 weeks gestation.
To determine pregnancy outcomes of patients who present with Stage I twin-to-twin transfusion syndrome (TTTS).This was a retrospective review all TTTS referred to our institution between January 2005 and December 2006. Quintero criteria were used for staging. Laser ablation not offered disease.A total 155 twin pregnancies evaluated during this period. Forty-two met the included in analysis. The overall survival discharge 82%. mean gestational age at time consultation 20.9 +/- 0.4 weeks. A 23...
<b><i>Objective:</i></b> Pregnancies at risk of fetal and neonatal alloimmune thrombocytopenia (FNAIT) are commonly treated using weekly intravenous immunoglobulin (IVIG) 1 g/kg maternal weight. IVIG is an expensive multidonor human blood product with dose-related side effects. Our aim was to evaluate the effectiveness a lower dose, i.e. 0.5 g/kg. <b><i>Methods:</i></b> This randomized controlled multicenter trial conducted in Sweden,...
The intervillous space of the placenta is a part fetal-maternal interface, where maternal blood enters to provide nutrients and gas exchange. Little known about immune cells at this site, which are in direct contact with fetal tissues. We have characterized T cell composition chemokine profile paired peripheral samples from healthy mothers giving birth following term pregnancies. Mucosal-associated invariant (MAIT) effector memory (EM) were enriched compared blood, suggesting that MAIT other...
Anti-D alloimmunization is the most common cause of severe hemolytic disease fetus and newborn (HDFN). The management pregnancies affected by less frequent red blood cell (RBC) antibodies poses a challenge to clinicians, perinatal outcomes are well described. This study aimed describe frequency clinically significant RBC in our pregnant population analyze risk prenatal postnatal treatment for HDFN relation national classification system guidelines.A retrospective cohort all alloimmunized...
To estimate the cost-effectiveness of first trimester non-invasive fetal RHD screening for targeted antenatal versus no routine anti-D prophylaxis (RAADP) or non-targeted RAADP.Model based on a population-based cohort study.The Swedish health service.Intervention subjects in underlying study were RhD-negative pregnant women receiving followed by 2010-2011 (n = 6723). Historical comparators who delivered 2008-2009 when standard care did not include RAADP 7099).Healthcare costs three...
Objectives . The aim of this study was to assess the incidence, prenatal detection rate by ultrasound, and pregnancy outcome spina bifida (SB) in Denmark (DK) 2008–2015 compare results national data from Sweden. Methods Data were retrieved Danish Fetal Medicine Database, which includes International Classification Diseases- (ICD-) 10 codes for pre- or postnatally diagnoses outcome. Missing obtained National Patient Register. Livebirth with myelomeningocele (MMC) Sweden different databases....
The aim of this study was to investigate the management and outcome in post-laser twin anemia polycythemia sequence (TAPS). Data international TAPS Registry, collected between 2014 2019, were used for study. primary outcomes perinatal mortality severe neonatal morbidity. Secondary included a risk factor analysis A total 164 pregnancies included, which 92% (151/164) diagnosed antenatally 8% (13/164) postnatally. median number days laser TTTS detection 14 (IQR: 7–28, range: 1–119). Antenatal...
Abstract Background Artificial intelligence (AI) is becoming increasingly used in medical education, but our understanding of the validity AI‐based assessments (AIBA) as compared with traditional clinical expert‐based (EBA) limited. In this study, authors aimed to compare and contrast evidence for assessment a complex skill based on scores generated from an AI trained experts, respectively. Methods The study was conducted between September 2020 October 2022. Kane's framework prioritise...
Abstract Objective To describe the outcome of children prenatally diagnosed with omphalocele, exstrophy cloaca, imperforate anus and spinal defects (OEIS). Method A retrospective study identified six fetuses OEIS from 2001 to 2007 data were collected pre‐ postnatal charts. Results Prenatal findings included an infraumbilical wall defect, no visible bladder defects. Abnormalities upper urinary tract seen in all cases ambiguous genitalia four. Four women continued pregnancy after prenatal...