A5010568536- Pregnancy and preeclampsia studies
- Blood Coagulation and Thrombosis Mechanisms
- Neonatal Respiratory Health Research
- Infant Nutrition and Health
- Preterm Birth and Chorioamnionitis
- Muscle metabolism and nutrition
- Hemoglobinopathies and Related Disorders
- Acute Lymphoblastic Leukemia research
- Nutritional Studies and Diet
- Blood groups and transfusion
- Protein Hydrolysis and Bioactive Peptides
- Neonatal Health and Biochemistry
- Gut microbiota and health
- Child Nutrition and Water Access
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Blood properties and coagulation
- Birth, Development, and Health
- Neonatal and fetal brain pathology
- Metabolism and Genetic Disorders
- Breastfeeding Practices and Influences
- Neuroinflammation and Neurodegeneration Mechanisms
- Gestational Diabetes Research and Management
- Spinal Cord Injury Research
- Ovarian cancer diagnosis and treatment
- Proteins in Food Systems
Janssen (United States)
2024-2025
Johnson & Johnson (United States)
2025
Morinaga (Japan)
2018-2024
Megmilk Snow Brand (Japan)
2021-2024
Leiden University Medical Center
2024
Hokkaido University
2009-2023
Research Triangle Park Foundation
2020-2021
GlaxoSmithKline (United States)
2017
National Defense Medical College
1994-2004
STMicroelectronics (France)
2003
In early-onset severe hemolytic disease of the fetus and newborn (HDFN), transplacental transfer maternal antierythrocyte IgG alloantibodies causes fetal anemia that leads to use high-risk intrauterine transfusions in order avoid hydrops death. Nipocalimab, an anti-neonatal Fc receptor blocker, inhibits lowers levels.
The INFOGEST method is a valuable tool for understanding and monitoring food digestion as an alternative to in vivo assays. However, few studies have compared animal protein sources terms of quality using the method. This study aimed evaluate milk-, plant-, insect-based materials by vitro digestibility digestible indispensable amino acid score (DIAAS), following Milk-based had highest (86.1-90.8%), followed soy (85.1%) wheat (82.3%). These significantly higher with zein (65.1%), cricket...
Objectives: Hemolytic disease of the fetus and newborn (HDFN) is a rare, immune-mediated red blood cell (RBC) disorder, where maternal IgG alloantibodies attack fetal RBCs. Nipocalimab fully human monoclonal antibody designed to selectively block binding site on neonatal Fc receptors (FcRn). Modeling approaches were used characterize pharmacokinetic/pharmacodynamic (PK/PD) exposure-response (E-R) relationships nipocalimab in Phase 2 UNITY study pregnancies at risk for EOS-HDFN.Methods:...
This article is a plain language summary of publication (PLSP) the following article: Design phase 3, global, multicenter, randomized, placebo-controlled, double-blind study nipocalimab in pregnancies at risk for severe hemolytic disease fetus and newborn by Komatsu et al published American Journal Perinatology on September 17, 2024 (doi:10.1055/a-2404-8089). PLSP describes design 3 AZALEA clinical trial pregnant participants developing (HDFN). In this study, researchers will determine if an...
Background: The gut microbiome and fecal metabolites of breastfed infants changes during lactation, are influenced by breast milk components. This study aimed to investigate dynamic associations components with the infant throughout lactation period in a mother-infant model. Methods: One month after delivery, subsequent feces were collected pair for 5 months from mother an exclusively infant. Composition was determined 16S rRNA sequencing. Low-molecular-weight metabolites, including human...
The redox state of plasma albumin shifts in response to dietary protein intake growing rats, and the shift is more sensitive than that level, a classical marker nutritional status. While it has been suggested could be useful as novel status, above animal model highly observation may not extrapolated widely humans. This study aimed investigate whether also reflects status adult which have lower requirement are less responsive intake. Male rats were placed on AIN-93M diet (14% casein), or...
ABSTRACT Many improvements have been made to bring infant formula (IF) closer human milk (HM) regarding its nutritional and biological properties. Nevertheless, the protein components of HM IF are still different, which may affect their digestibility. This study aimed evaluate compare digestibility using INFOGEST digestion method. Pooled a commercial were subjected method, simulates physiological conditions infants, with multiple directions, i.e. , curd state, SDS-PAGE, molecular weight...
Maternal diet may affect human milk macronutrients, but it remains to be elucidated whether this is also influential in infant growth. This study aimed examine (1) how maternal influences and (2) what extent the variation macronutrients affects growth during first month of life. In 71 Japanese lactating women, dietary information was collected from brief-type self-administered history questionnaire, anthropometry mother–infant dyads medical records. Macronutrients were analyzed by a Human...
The aim of this study is to assess the efficacy and safety retosiban in spontaneous preterm labor (sPTL).Two multicenter, randomized, double-blind trials compared with placebo atosiban women a singleton pregnancy intact membranes sPTL at 24 336/7 weeks' gestation. Coprimary endpoints placebo-controlled trial were time delivery (TTD) or treatment failure (whichever occurred first) neonatal composite morbidity mortality. primary endpoint comparator was TTD.The terminated early because slow...
Abstract We previously demonstrated that N ‐methyl‐ d ‐aspartate (NMDA) treatment (50 μ m , 3 h) induced astrocytic production of monocyte chemoattractant protein‐1 (MCP‐1, CCL2), a CC chemokine implicated in ischemic and excitotoxic brain injury, rat corticostriatal slice cultures. In this study, we investigated the signaling mechanisms for NMDA‐induced MCP‐1 The results showed close correlation between neuronal injury production, an abrogation NMDA‐pretreated slices where cells had been...
We recently reported that plasma albumin redox state, which correlates with synthesis rate, could be associated the quality of dietary protein. Aiming to elucidate association between them, state was investigated in rats fed various kinds AIN-93G-based low protein diets. Plasma shifted a more oxidized 3% casein (CN) diet than those whey or wheat gluten diet, while supplementing CN cystine reversed it reduced indicating would complement shortage cysteine CN, thereby increasing rate....
Background: Plasma albumin (ALB) reflects protein nutritional status in rats, but it is not clear whether associated with dietary insufficiency pregnant women and/or their risk of low birth weight delivery. This study aimed to investigate maternal serum ALB redox state infant weights. Methods: The relationship between the reduced ratio and was examined an observational 229 Japanese women. A rat model simulating fetal growth restriction, induced by protein-energy used elucidate status, state,...
Protein undernutrition contributes to the development of various diseases in broad generations. Urinary metabolites may serve as non-invasive biomarkers protein undernutrition; however, this requires further investigation. We aimed identify novel urinary biomarker candidates responsive undernutrition. Adult rats were fed control (CT; 14 % casein) or isoenergetic low-protein (LP; 5 diets for 4 weeks. 1H NMR metabolomics was applied urine, plasma and liver samples Liver subjected mRNA...
No AccessJournal of Urology1 Apr 1983Improvement Ejaculatory Incompetence with Bromocriptine in a Man Prolactin-Secreting Pituitary Tumor Fumimaro Oseko, Ataru Taniguchi, Tsuyoshi Kono, Hiroo Imura, and Yosuke Komatsu OsekoFumimaro Oseko Current address: Frist Division Internal Medicine, Shimane Medical University, 89-1 Enya-cho, Izumo, Shimane, 693, Japan. More articles by this author , TaniguchiAtaru Taniguchi KonoTsuyoshi Kono ImuraHiroo Imura KomatsuYosuke View All Author...