A5005028870- Infant Nutrition and Health
- MicroRNA in disease regulation
- Muscle metabolism and nutrition
- Gut microbiota and health
- Extracellular vesicles in disease
- RNA Interference and Gene Delivery
- Probiotics and Fermented Foods
- Glycosylation and Glycoproteins Research
- Nutritional Studies and Diet
- Digestive system and related health
- Effects of Radiation Exposure
- Cytokine Signaling Pathways and Interactions
- Neonatal Respiratory Health Research
- Mesenchymal stem cell research
- Protein purification and stability
- Immune Response and Inflammation
- Diet and metabolism studies
- Hepatitis B Virus Studies
- Radiation Therapy and Dosimetry
- Hepatitis C virus research
- Clinical Nutrition and Gastroenterology
- Drug Transport and Resistance Mechanisms
- Gestational Diabetes Research and Management
- Folate and B Vitamins Research
- Caveolin-1 and cellular processes
Morinaga (Japan)
2004-2022
Hokkaido University
2018-2022
Megmilk Snow Brand (Japan)
2019-2022
Kyoto University
1981-2004
Osaka University
1961-2003
Kanazawa Medical University
2002
Japanese Red Cross Medical Center
1999
Fondation ARC pour la Recherche sur le Cancer
1986
Institut Gustave Roussy
1986
Inserm
1986
Breast milk is a complex liquid that provides nutrition to the infant and facilitates maturation of infant's immune system. Recent studies indicated microRNA (miRNA) exists in human body fluid. Because miRNAs are known regulate various systems, we hypothesized breast contains may be important for development system.We profiled miRNA expression detected high levels immune-related first 6 months lactation. Furthermore, these molecules stable even very acidic conditions, indicating allows...
Functional RNAs, such as microRNA (miRNA) and mRNA, are present in milk, but their roles unknown. To clarify the of milk further studies using experimental animals rats needed. However, it is unclear whether rat also contains functional RNAs what time dependent expression profiles are. Thus, we prepared total RNA from whey isolated collected on days 2, 9, 16 postpartum analyzed microarrays quantitative PCR. The concentration colostrum (day 2) was markedly higher than that mature (days 9 16)....
Necrotising enterocolitis (NEC) is associated with inflammatory responses and barrier dysfunction in the gut. In this study, we investigated effect of Bifidobacterium breve M-16V on factors related to NEC development using an experimental rat model. Caesarean-sectioned rats were given formula milk or without B. by oral gavage thrice daily, was induced exposing hypoxic conditions. Naturally delivered that reared their mother used as healthy controls. The pathological score expression...
Abstract It is important to provide formula-fed infants with a bifidobacteria-enriched gut microbiota similar those of breastfed ensure intestinal health. Prebiotics, such as certain oligosaccharides, are useful solution this problem, but the combinational benefits these oligosaccharides have not been evaluated. This study investigated oligosaccharide combinations and screened for an optimal combination promote healthy infants. In vitro in vivo experiments were performed assess bifidogenic...
Background: The gut microbiome and fecal metabolites of breastfed infants changes during lactation, are influenced by breast milk components. This study aimed to investigate dynamic associations components with the infant throughout lactation period in a mother-infant model. Methods: One month after delivery, subsequent feces were collected pair for 5 months from mother an exclusively infant. Composition was determined 16S rRNA sequencing. Low-molecular-weight metabolites, including human...
The redox state of plasma albumin shifts in response to dietary protein intake growing rats, and the shift is more sensitive than that level, a classical marker nutritional status. While it has been suggested could be useful as novel status, above animal model highly observation may not extrapolated widely humans. This study aimed investigate whether also reflects status adult which have lower requirement are less responsive intake. Male rats were placed on AIN-93M diet (14% casein), or...
<i>Background:</i> Neonatal necrotizing enterocolitis (NEC) is the most common gastrointestinal emergency in premature infants. The mortality rate associated with NEC quite high and reports ranges from 20 to 30%. Despite extensive studies, pathogenesis of remains poorly understood. <i>Objectives:</i> To investigate mechanisms terms inflammatory signaling intestine. <i>Methods:</i> A new model was established examined expression anti-inflammatory signals...
Abstract Background Epicutaneous sensitization to food allergens can occur through defective skin barriers. However, the relationship between oral tolerance and epicutaneous remains be elucidated. We aimed determine whether prior exposure whey proteins or their hydrolysates prevents subsequent food‐allergic reaction protein, β‐lactoglobulin (β‐ LG ), investigated underlying mechanisms. Methods BALB /c mice were given protein concentrate ( WPC two kinds of partial hydrolysate PWH 1 2),...
We recently reported that plasma albumin redox state, which correlates with synthesis rate, could be associated the quality of dietary protein. Aiming to elucidate association between them, state was investigated in rats fed various kinds AIN-93G-based low protein diets. Plasma shifted a more oxidized 3% casein (CN) diet than those whey or wheat gluten diet, while supplementing CN cystine reversed it reduced indicating would complement shortage cysteine CN, thereby increasing rate....
Background: Plasma albumin (ALB) reflects protein nutritional status in rats, but it is not clear whether associated with dietary insufficiency pregnant women and/or their risk of low birth weight delivery. This study aimed to investigate maternal serum ALB redox state infant weights. Methods: The relationship between the reduced ratio and was examined an observational 229 Japanese women. A rat model simulating fetal growth restriction, induced by protein-energy used elucidate status, state,...
We investigated the effects of endogenous glucagon-like peptide-2 (GLP-2) on development intestinal mucosa in weanling rats. Three-week-old male Sprague-Dawley rats were administered either anti-GLP-2 or normal rabbit serum every other day for 2 weeks. then measured length, weight, and bromodeoxyuridine incorporation intestine 13 following first injection. Administration significantly inhibited both epithelial proliferation distal ileum elongation small intestine. These results suggest that...