A5008736482- Gut microbiota and health
- Probiotics and Fermented Foods
- Clostridium difficile and Clostridium perfringens research
- Diet and metabolism studies
- Infant Nutrition and Health
- Digestive system and related health
- Genomics and Phylogenetic Studies
- Microbial Metabolites in Food Biotechnology
- Infant Health and Development
- Gastrointestinal motility and disorders
- Enzyme Production and Characterization
- Frailty in Older Adults
- Pancreatic and Hepatic Oncology Research
- Ginseng Biological Effects and Applications
- Gallbladder and Bile Duct Disorders
- Viral gastroenteritis research and epidemiology
- Colorectal Cancer Screening and Detection
- Polysaccharides and Plant Cell Walls
- Pediatric health and respiratory diseases
- Bacteriophages and microbial interactions
- Machine Learning in Healthcare
- Protein Hydrolysis and Bioactive Peptides
- Microbial Metabolic Engineering and Bioproduction
- Tryptophan and brain disorders
- Mycobacterium research and diagnosis
Morinaga (Japan)
2016-2025
Megmilk Snow Brand (Japan)
2016-2025
Innovative Research (United States)
2025
Kyoto University
2021-2025
Juntendo University
2022
National Institute of Infectious Diseases
2021
Niigata University
2021
National Institute of Biomedical Innovation, Health and Nutrition
2020
Chang Industry (United States)
2020
APC Microbiome Institute
2019
It has been reported that the composition of human gut microbiota changes with age; however, few studies have used molecular techniques to investigate long-term, sequential in composition. In this study, we investigated newborn centenarian Japanese subjects.Fecal samples from 367 healthy subjects between ages 0 and 104 years were analyzed by high-throughput sequencing amplicons derived V3-V4 region 16S rRNA gene. Analysis based on bacterial co-abundance groups (CAGs) defined Kendall...
The human gut microbiota established during infancy has persistent effects on health. In vitro studies have suggested that milk oligosaccharides (HMOs) in breast promote the formation of a bifidobacteria-rich infant guts; however, underlying molecular mechanism remains elusive. Here, we characterized two functionally distinct but overlapping fucosyllactose transporters (FL transporter-1 and -2) from Bifidobacterium longum subspecies infantis. Fecal DNA HMO consumption analyses, combined with...
Probiotics use has been associated with modulation of inflammation and considered as a possible intervention for CNS diseases such mild cognitive impairment (MCI) dementia.We aimed to test the effect probiotic strain, Bifidobacterium breve A1 (MCC1274), restore cognition in physically healthy, suspected MCI population.In this randomized, double-blind, placebo-controlled trial, 80 healthy older adults suffering from were divided into two even groups receive once daily either (B. A1, 2×1010...
The aim of the present study was to evaluate anti-obesity activity a probiotic bifidobacterial strain in mouse model with obesity induced by high-fat diet. mice were fed diet supplemented Bifidobacterium breve B-3 at 108 or 109 CFU/d for 8 weeks. B. supplementation dose-dependently suppressed accumulation body weight and epididymal fat, improved serum levels total cholesterol, fasting glucose insulin. counts caecal contents feces significantly increased administration. expression genes...
Summary Background Probiotic bacteria may be effective in the treatment of allergic inflammation and food allergy, but efficacy underlying mechanisms remain unclear. Objective The present study investigated effects probiotic strain Bifidobacterium longum BB536 Japanese cedar pollinosis (JCPsis). Methods In a randomized, double‐blind, placebo‐controlled trial, 44 JCPsis subjects received or placebo for 13 weeks during pollen season. Subjective symptoms self‐care measures were recorded daily...
Bifidobacteria are one of the major components in human microbiota that suggested to function maintaining health. The colonization and cell number Bifidobacterium species intestine vary with ageing. However, sequential changes ranging from newborns centenarians remain unresolved. Here, we investigated gut compositional over a wide range ages. Faecal samples 441 healthy Japanese subjects between ages 0 104 years were analysed using real-time PCR species-specific primers. B. longum group was...
Probiotics are well known as health-promoting agents that modulate intestinal microbiota. However, the molecular mechanisms underlying this effect remain unclear. Using gnotobiotic mice harboring 15 strains of predominant human gut-derived microbiota (HGM), we investigated effects Bifidobacterium longum BB536 (BB536-HGM) supplementation on gut luminal metabolism. Nuclear magnetic resonance (NMR)-based metabolomics showed significantly increased fecal levels pimelate, a precursor biotin, and...
Probiotic administration may be a useful method for preventing allergies in infants; however, there have been controversial results about the efficacy. We investigated effects of bifidobacterial supplementation on risk developing allergic diseases Japanese population.In an open trial, we gave Bifidobacterium breve M-16V and longum BB536 prenatally to 130 mothers beginning 1 month prior delivery postnatally their infants 6 months. Another 36 mother-infant pairs served as controls did not...
Bifidobacterium longum subsp. represents one of the most prevalent bifidobacterial species in infant, adult and elderly (human) gut. In current study, we performed a comparative genome analysis involving 145 B. representatives, including 113 strains obtained from healthy Japanese subjects aged between 0 98 years. Although MCL clustering did not reveal any correlation isolated subject age, certain characteristics appear to be more among corresponding specific host ages, such as genes involved...
Gastrointestinal microbiota have been implicated in the pathogenesis of various gastrointestinal disorders dogs, including acute diarrhea and chronic enteropathy. Metronidazole prednisolone are commonly prescribed for treatment these diseases; however, their effects on not investigated. The objective this study was to evaluate drugs dogs. administered twice daily at 12.5 mg/kg a group five healthy 1.0 second dogs 14 days. Fecal samples were collected before after administration (day 0 14),...
Probiotics have shown great promise in promoting human health. Despite the promising evidence, there is little information on clinical efficacy of many available probiotics and their mechanisms action are often unclear. Bifidobacterium longum subsp. BB536 a clinically effective, well-established, multifunctional probiotic that has long history use alleviating gastrointestinal, immunological infectious diseases. This review summarizes functional benefits from most relevant animal studies...
Abstract Accumulating evidence suggests an association between gut microbiota and the development of obesity, raising possibility probiotic administration as a therapeutic approach. Bifidobacterium breve B-3 was found to exhibit anti-obesity effect on high-fat diet-induced obesity mice. In present study, randomised, double-blind, placebo-controlled trial conducted evaluate consumption B. body compositions blood parameters in adults with tendency for obesity. After 4-week run-in period,...
Recent studies have shown that metabolites produced by microbes can be considered as mediators of host-microbial interactions. In this study, we examined the production tryptophan Bifidobacterium strains found in gastrointestinal tracts humans and other animals. Indole-3-lactic acid (ILA) was only metabolite bifidobacteria culture supernatants. No others, including indole-3-propionic acid, indole-3-acetic indole-3-aldehyde, were produced. Strains bifidobacterial species commonly isolated...
Bifidobacteria are among the first colonizers of infant gut, and human milk oligosaccharides (HMOs) in breastmilk instrumental for formation a bifidobacteria-rich microbiota. However, little is known about assembly bifidobacterial communities. Here, by applying theory to community four representative infant-gut associated Bifidobacterium species that employ varied strategies HMO consumption, we show arrival order sugar consumption phenotypes significantly affected formation. bifidum longum...
Indole in the gut is formed from dietary tryptophan by a bacterial tryptophan-indole lyase. not only triggers biofilm formation and antibiotic resistance microbes but also contributes to progression of kidney dysfunction after absorption intestine sulfation liver. As an essential amino acid for humans, these events seem inevitable. Despite this, we show proof-of-concept study that exogenous indole can be converted immunomodulatory metabolite, indole-3-lactic (ILA), previously unknown...
This study investigated the potential utilization of lacto-N-biose I (LNB) by individual strains bifidobacteria. LNB is a building block for human milk oligosaccharides, which have been suggested to be factor selective growth A total 208 comprising 10 species and 4 subspecies were analyzed presence galacto-N-biose/lacto-N-biose phosphorylase (GLNBP) gene (lnpA) examined when was used as sole carbohydrate source. While all Bifidobacterium longum subsp. longum, B. infantis, breve, bifidum able...
Bifidobacteria are known to produce folate, a vital nutrient for humans. Previous studies have suggested that the ability folate is strain dependent, but further adequate evaluation needed. In this study, total of 44 strains, including 12 species and 7 subspecies, bifidobacteria were investigated production during cultivation in medium containing essential levels growth tested strains. An vitro assay showed all strains human-residential (HRB) able whereas most non-HRB not, with exception B....
Abstract Aim Recent studies have suggested that oral bacteria induce systemic inflammation through the alteration of gut microbiota. We examined relationship between and microbiota to evaluate transition gastrointestinal tract. Methods Oral samples from subgingival plaque tongue‐coating fecal were collected 29 elderly subjects (age, 80.2 ± 9.1 years) 30 adults 35.9 5.0 years). Genomic DNA was extracted all samples, sequencing bacterial 16S rRNA genes performed for analysis. UniFrac distances...
Probiotics are live microorganisms that confer a health benefit on the host, such as improvement of intestinal environment, modulation immune function and energy metabolism. Heat-killed probiotic strains have also been known to exhibit some physiological functions; however, differences between heat-killed probiotics not well elucidated. In this study, we investigated Bifidobacterium breve M-16V, strain, in regulation function, metabolism gene expression host using gnotobiotic mouse model...
Extracellular proteins are important factors in host-microbe interactions; however, the specific that enable bifidobacterial adhesion and survival gastrointestinal (GI) tract not fully characterized. Here, we discovered Bifidobacterium longum NCC2705 cultured bacterium-free supernatants of human fecal fermentation broth released a myriad particles into extracellular environment. The aim this study was to characterize physiological properties these particles. particles, approximately 50 80 nm...
Faecalibacterium prausnitzii is a commensal gut bacterium that thought to provide protection against inflammatory diseases. However, this extremely oxygen sensitive, which limits its industrial application as probiotic. The use of prebiotics increase the abundance in an alternative strategy achieve possible health-promoting effect. We evaluated nine substances candidate for F. using pH-controlled single-batch fermenter human microbiota model. Of them, alginate markedly increased relative...