A5102796923- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Neuroscience and Neuropharmacology Research
- Genetics and Neurodevelopmental Disorders
- Posttraumatic Stress Disorder Research
- Receptor Mechanisms and Signaling
- Resilience and Mental Health
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetic Associations and Epidemiology
- Disaster Response and Management
- Sulfur Compounds in Biology
- Phosphodiesterase function and regulation
- Nutrition, Health and Food Behavior
- Healthcare professionals’ stress and burnout
- Hormonal and reproductive studies
- MicroRNA in disease regulation
- Nutritional Studies and Diet
- Genomics, phytochemicals, and oxidative stress
- Biochemical effects in animals
- Sexual Differentiation and Disorders
- Systemic Lupus Erythematosus Research
- Genomic variations and chromosomal abnormalities
- Asthma and respiratory diseases
- Schizophrenia research and treatment
- Congenital heart defects research
National Defense Medical College
2018-2024
National Defence Medical Centre
2022
Hokkaido University
2016-2021
Ube (Japan)
2021
Waseda University
2020
Johns Hopkins Medicine
2011-2017
Johns Hopkins University
2011-2017
Yamaguchi University
2017
University of Tsukuba
2005-2012
Japan Science and Technology Agency
2005-2011
Opioids, such as morphine and fentanyl, are widely used effective analgesics for the treatment of acute chronic pain. In addition, opioid system has a key role in rewarding effects morphine, ethanol, cocaine various other drugs. Although sensitivity is well known to vary among individual subjects, several candidate genetic polymorphisms reported so far not sufficient fully understanding wide range interindividual differences human sensitivity. By conducting multistage genome-wide association...
Chromatin remodeling may play a role in the neurobiology of schizophrenia and process, therefore, be considered as therapeutic target. The SMARCA2 gene encodes BRM SWI/SNF chromatin-remodeling complex, associations single nucleotide polymorphisms (SNPs) to were found two linkage disequilibrium blocks after screening 11 883 SNPs (rs2296212; overall allelic P = 5.8 × 10−5) subsequent 22 genes involved chromatin (rs3793490; 2.0 10−6) Japanese population. A risk allele missense polymorphism...
Neuroleptic-induced tardive dyskinesia (TD) is an involuntary movement disorder that develops in patients who have undergone long-term treatment with antipsychotic medications, and its etiology unclear. In this study, a genome-wide association screening was done to identify the pathway(s) which genetic variations influence susceptibility neuroleptic-induced TD.Screening Sentrix Human-1 Genotyping BeadChip (Illumina, San Diego, California, USA) for 50 Japanese schizophrenia...
Schizophrenia and other neuropsychiatric disorders await mechanism-associated interventions. Excess oxidative stress is increasingly appreciated to participate in the pathophysiology of brain disorders, decreases major antioxidant, glutathione (GSH), have been reported multiple studies. Technical cautions regarding estimation stress-related changes via imaging techniques led investigators explore peripheral GSH as a possible pathological signature stress-associated changes. In preclinical...
Abstract Introduction Recent studies identified STAT4 (signal transducers and activators of transcription-4) as a susceptibility gene for systemic lupus erythematosus (SLE). STAT1 is encoded adjacently to on 2q32.2-q32.3, upregulated in peripheral blood mononuclear cells from SLE patients, functionally relevant SLE. This study was conducted test whether associated with Japanese population also, identify the risk haplotype, examine potential genetic contribution . To accomplish these aims, we...
Healthcare providers frequently help traumatized people and are regularly exposed to indirect trauma from their work, resulting in negative psychological responses, such as secondary traumatic stress. Empathy has been associated with patient's quality of care stress among healthcare providers. However, the relationship between dispositional empathy not fully elucidated. This study used person- variable-centered approaches explore nature this relationship.A total 1,006 Japanese public health...
Wistar rats subjected to a single exposure lasting six hours ethylene oxide (EO) at concentration of 500 parts per million three times week for 13 weeks developed ataxia in the hindlegs. Myelinated fibres hindleg nerves and fasciculus gracilis showed axonal degeneration sparing nerve cell body lumbar dorsal root ganglion myelinated ventral roots. These pathological findings are compatible with central-peripheral distal degeneration. This is first animal model EO neuropathy be...