Masanari Itokawa
A5013257622- Advanced Glycation End Products research
- Receptor Mechanisms and Signaling
- Genomic variations and chromosomal abnormalities
- Genetic Associations and Epidemiology
- Neurotransmitter Receptor Influence on Behavior
- Genetics and Neurodevelopmental Disorders
- Schizophrenia research and treatment
- Tryptophan and brain disorders
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Bipolar Disorder and Treatment
- Alcohol Consumption and Health Effects
- Diet and metabolism studies
- Genomics and Rare Diseases
- Diabetes and associated disorders
- Neuroscience and Neuropharmacology Research
- Congenital heart defects research
- Folate and B Vitamins Research
- Alcoholism and Thiamine Deficiency
- Autism Spectrum Disorder Research
- Amino Acid Enzymes and Metabolism
- Advanced X-ray Imaging Techniques
- Neuropeptides and Animal Physiology
- Epigenetics and DNA Methylation
- Alzheimer's disease research and treatments
Tokyo Metropolitan Institute of Medical Science
2016-2025
Tokyo Metropolitan Matsuzawa Hospital
2013-2025
The University of Tokyo
2023-2025
Niigata University
2022-2023
RIKEN Center for Brain Science
2003-2017
Tokyo Institute of Psychiatry
2003-2013
Japan Science and Technology Agency
2005-2011
Schizophrenia Research Institute
2003-2011
RIKEN
2011
RELX Group (United States)
2006
Cocaine blocks uptake by neuronal plasma membrane transporters for dopamine (DAT), serotonin (SERT), and norepinephrine (NET). reward/reinforcement has been linked to actions at DAT or blockade of SERT. However, knockouts neither DAT, SERT, NET reduce cocaine reward/reinforcement, leaving substantial uncertainty about cocaine's molecular mechanisms reward. Conceivably, the bases reward might display sufficient redundancy that either SERT be able mediate in other's absence. To test this...
Compelling evidence in Caucasian populations suggests a role for copy-number variations (CNVs) autism spectrum disorder (ASD) and schizophrenia (SCZ). We analyzed 1,108 ASD cases, 2,458 SCZ 2,095 controls Japanese population confirmed an increased burden of rare exonic CNVs both disorders. Clinically significant (or pathogenic) CNVs, including those at 29 loci common to disorders, were found about 8% which was significantly higher than controls. Phenotypic analysis revealed association...
Genome-wide association studies (GWASs) have identified several susceptibility loci for bipolar disorder (BD) and shown that the genetic architecture of BD can be explained by polygenicity, with numerous variants contributing to BD. In present GWAS (Phase I/II), which included 2964 61 887 control subjects from Japanese population, we detected a novel locus at 11q12.2 (rs28456, P=6.4 × 10−9), region known contain regulatory genes plasma lipid levels (FADS1/2/3). A subsequent meta-analysis...
<h3>Context</h3> Various factors are involved in the pathogenesis of schizophrenia. Accumulation advanced glycation end products, including pentosidine, results from carbonyl stress, a state featuring an increase reactive compounds (RCOs) and their attendant protein modifications. Vitamin B<sub>6</sub>is known to detoxify RCOs, products. Glyoxalase I (GLO1) is one enzymes required for cellular detoxification RCOs. <h3>Objectives</h3> To examine whether plasma levels pentosidine serum vitamin...
Opioids, such as morphine and fentanyl, are widely used effective analgesics for the treatment of acute chronic pain. In addition, opioid system has a key role in rewarding effects morphine, ethanol, cocaine various other drugs. Although sensitivity is well known to vary among individual subjects, several candidate genetic polymorphisms reported so far not sufficient fully understanding wide range interindividual differences human sensitivity. By conducting multistage genome-wide association...
Glyoxalase I catalyses the isomerization of hemithioacetal formed non-enzymatically from methylglyoxal and glutathione to S-D-lactoylglutathione. The activity glyoxalase is conventionally measured spectrophotometrically by following increase in A240 for which change molar absorption coefficient Δε240=2.86 mM⁻¹·cm⁻¹. pre-formed situ incubation 50 mM sodium phosphate buffer (pH 6.6) at 37°C 10 min. cell extract then added, monitored over 5 min, initial rate hence deduced with correction blank....
Psychotic disorders are a significant risk factor for suicide, especially among young people. Psychotic-like experiences (PLEs) in the general population may share an etiological background with psychotic disorders. Therefore, present study examined association between PLEs and of suicide community sample adolescents.Psychotic-like experiences, suicidal feelings, self-harm behaviors were studied using self-report questionnaire administered to 5073 Japanese adolescents. Depression anxiety...
Chromatin remodeling may play a role in the neurobiology of schizophrenia and process, therefore, be considered as therapeutic target. The SMARCA2 gene encodes BRM SWI/SNF chromatin-remodeling complex, associations single nucleotide polymorphisms (SNPs) to were found two linkage disequilibrium blocks after screening 11 883 SNPs (rs2296212; overall allelic P = 5.8 × 10−5) subsequent 22 genes involved chromatin (rs3793490; 2.0 10−6) Japanese population. A risk allele missense polymorphism...
The biological dose of nuclear workers engaged in emergency response tasks at Tokyo Electric Power Company (TEPCO) Fukushima Daiichi Nuclear Station was estimated the present study. As national core center for radiation medical preparedness Japan, National Institute Radiological Sciences (NIRS) received all individuals who were suspected being overexposed to acute radiation. In course health examinations NIRS, dosimetry performed by dicentric chromosome assay (DCA). Twelve examined from 21...
Article28 October 2019Open Access Source DataTransparent process Excess hydrogen sulfide and polysulfides production underlies a schizophrenia pathophysiology Masayuki Ide Laboratory of Molecular Psychiatry, RIKEN Center for Brain Science, Wako, Saitama, Japan Department Division Clinical Medicine, Faculty University Tsukuba, Ibaraki, Search more papers by this author Tetsuo Ohnishi Manabu Toyoshima Shabeesh Balan orcid.org/0000-0002-1098-1290 Motoko Maekawa Chie Shimamoto-Mitsuyama Yoshimi...
BackgroundWe aimed to determine the similarities and differences in roles of genic regulatory copy number variations (CNVs) bipolar disorder (BD), schizophrenia (SCZ), autism spectrum (ASD).MethodsBased on high-resolution CNV data from 8708 Japanese samples, we performed our knowledge largest cross-disorder analysis CNVs BD, SCZ, ASD.ResultsIn CNVs, found an increased burden smaller (<100 kb) exonic deletions which contrasted with highest larger (>500 SCZ/ASD. Pathogenic linked...
Abstract Recent progress in genotyping technology and the development of public databases has enabled large‐scale genome‐wide association tests with diseases. We performed a two‐stage study (GWAS) bipolar disorder (BD) Japanese cohorts. First we used Affymetrix 100K GeneChip arrays analysis 107 cases I controls, selected markers that were nominally significant ( P < 0.01) at least one three models (1,577 total). In follow‐up stage, analyzed these using an Illumina platform (1,526 markers;...
Background Although structural magnetic resonance imaging (MRI) studies have repeatedly demonstrated regional brain abnormalities in patients with schizophrenia, relatively few MRI-based attempted to distinguish between first-episode schizophrenia and healthy controls. Method Three-dimensional MR images were acquired from 52 (29 males, 23 females) 40 (22 18 subjects. Multiple measures (regional volume cortical thickness) calculated by a fully automated procedure used for group comparison...