A5101922364- Vitamin D Research Studies
- Adaptive optics and wavefront sensing
- Astronomy and Astrophysical Research
- Amino Acid Enzymes and Metabolism
- Stellar, planetary, and galactic studies
- Epigenetics and DNA Methylation
- Metabolism and Genetic Disorders
- Growth Hormone and Insulin-like Growth Factors
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Extracellular vesicles in disease
- Cancer-related gene regulation
- Optical Systems and Laser Technology
- T-cell and B-cell Immunology
- Digestive system and related health
- Immune Cell Function and Interaction
- Biotin and Related Studies
- Coordination Chemistry and Organometallics
- interferon and immune responses
- RNA regulation and disease
- Fluorine in Organic Chemistry
- Aldose Reductase and Taurine
- Cancer-related molecular mechanisms research
- Calibration and Measurement Techniques
- Eicosanoids and Hypertension Pharmacology
Nara Medical University
2019-2024
Japanese Foundation For Cancer Research
2019-2024
Nara Medical University Hospital
2024
Nihon University
2010-2024
Daiichi Sankyo (United States)
2024
National Institute of Biomedical Innovation, Health and Nutrition
2023
Tokyo University of Science
2023
Kwansei Gakuin University
2020-2022
Las Cumbres Observatory Global Telescope Network
2008-2022
Fuji Electric (Japan)
2022
Abstract The Hyper Suprime-Cam (HSC) is an 870 megapixel prime focus optical imaging camera for the 8.2 m Subaru telescope. wide-field corrector delivers sharp images of 0${^{\prime\prime}_{.}}$2 (FWHM) in HSC-i band over entire 1${^{\circ}_{.}}$5 diameter field view. collimation with respect to axis primary mirror done hexapod actuators, mechanical accuracy which a few microns. Analysis remaining wavefront error off-focus stellar reveals that components meets design specifications. While...
Abstract To examine the cross talk between abscisic acid (ABA) and ethylene signal transduction pathways, signaling events during ABA-induced stomatal closure were examined in Arabidopsis (Arabidopsis thaliana) wild-type plants, an ethylene-overproducing mutant (eto1-1), two ethylene-insensitive mutants (etr1-1 ein3-1). Using isolated epidermal peels, stomata of plants found to close within a few minutes response ABA, whereas eto1-1 showed similar but less sensitive ABA response. In...
Hyper Suprime-Cam (HSC) is an 870 Mega pixel prime focus camera for the 8.2 m Subaru telescope. The wide field corrector delivers sharp image of 0.25 arc-sec FWHM in r-band over entire 1.5 degree (in diameter) view. collimation with respect to optical axis primary mirror realized by hexapod actuators whose mechanical accuracy few microns. As a result, we expect have seeing limited most time. Expected median 0.67 i-band. sensor p-ch fully depleted CCD 200 micron thickness (2048 x 4096 15 μm...
The Hyper Suprime-Cam Subaru Strategic Program (HSC-SSP) is a three-layered imaging survey aimed at addressing some of the most outstanding questions in astronomy today, including nature dark matter and energy. has been awarded 300 nights observing time Telescope it started March 2014. This paper presents first public data release HSC-SSP. includes taken 1.7 years observations (61.5 nights) each Wide, Deep, UltraDeep layers covers about 108, 26, 4 square degrees down to depths i~26.4, ~26.5,...
Abstract Hard carbon (HC) is a promising negative‐electrode material for Na‐ion batteries. HC electrochemically stores Na + ions, resulting in non‐stoichiometric chemical composition depending on their nanoscale structure, including the framework, and interstitial pores. Therefore, optimizing these structures storage by altering synthesis conditions can enhance capacity of In this study, HCs using MgO, ZnO, CaCO 3 as nanopore templates are systematically investigated, ZnO template found to...
ABSTRACT Arbuscular mycorrhizal fungi can enhance nutrient acquisition by a plant via their extraradical hyphae. This is particularly true for phosphorus, but the case nitrogen (N) has been less clear. In our growth systems there was small air‐gap between root and hyphal compartments, which eliminated diffusion of nutrients compartments. Moreover, methods allowed us to distinguish nitrate ammonium. We found that N transfer Zea maize L. depends on sources fed hyphae Glomus aggregatum Schenck...
Levels of endogenous abscisic acid (ABA) are changed dynamically in response to environmental conditions. The ABA 8′-hydroxylase is a key enzyme catabolism and encoded by CYP707A genes. In this study, we examined physiological roles Arabidopsis (Arabidopsis thaliana) CYP707As the plant's changes humidity. cyp707a1 cyp707a3 mutants displayed lower stomatal conductance under turgid conditions (relative humidity 60%) than wild type. When wild-type plants were transferred high-humidity 90%),...
Cytokinins and auxins are major phytohormones involved in various aspects of plant growth development. These also known to antagonize the effects abscisic acid (ABA) on stomatal movement, affect ethylene biosynthesis. As has an antagonistic effect ABA-induced closure, possibility that these ABA were mediated through biosynthesis was investigated. Both cytokinin, 6-benzyladenine (BA), auxin, 1-naphthaleneacetic (NAA), antagonized closure a manner similar following application precursor,...
Nephrectomized vitamin D-defkient rats on a low-calcium diet show the same intestinal calcium transport response to 1,25-dihydroxyvitamin D3 whether parathyroid hormone is present or not. Additionally, D-deficient low phosphorus give an equal sham-operated controls even 4 days after thyroparathyroidectomy. On other hand, only partial mobilization of from body stores in noted thyroparathyroidectomized rats. This can be restored with exogenous extract (10 units every 6 hr). Thus has direct...
<h3>Context</h3> Various factors are involved in the pathogenesis of schizophrenia. Accumulation advanced glycation end products, including pentosidine, results from carbonyl stress, a state featuring an increase reactive compounds (RCOs) and their attendant protein modifications. Vitamin B<sub>6</sub>is known to detoxify RCOs, products. Glyoxalase I (GLO1) is one enzymes required for cellular detoxification RCOs. <h3>Objectives</h3> To examine whether plasma levels pentosidine serum vitamin...
The number and density of stomata are controlled by endogenous environmental factors. Despite recent advances in our understanding stomatal development, mechanisms which prevent stomatal-lineage entry remain unclear. Here, we propose that abscisic acid (ABA), a phytohormone known to induce closure, limits initiation development induces enlargement pavement cells Arabidopsis cotyledons. An ABA-deficient aba2-2 mutant had an increased number/proportion within smaller cotyledon, as well reduced...
Weanling female rats were fed a vitamin D-deficient diet for 4 months until they reached maturity. They mated with normal, D-replete male and, at 20 days of pregnancy, the killed and their placentae removed, homogenzied, incubated 25-hydroxyvitamin D3. The incubation mixtures extracted extracts subjected to Sephadex LH-20 column chromatography followed by high-pressure liquid chromatography. 1,25-dihydroxyvitamin D3 region chromatogram was recycled purity structure product identified as...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT21,25-Dihydroxycholecalciferol. A metabolite of vitamin D3 preferentially active on boneTatsuo Suda, Hector F. DeLuca, Heinrich K. Schnoes, Gerard Ponchon, Yoko Tanaka, and Michael HolickCite this: Biochemistry 1970, 9, 14, 2917–2922Publication Date (Print):July 7, 1970Publication History Published online1 May 2002Published inissue 7 July 1970https://pubs.acs.org/doi/10.1021/bi00816a025https://doi.org/10.1021/bi00816a025research-articleACS...
PFS (Prime Focus Spectrograph), a next generation facility instrument on the 8.2-meter Subaru Telescope, is very wide-field, massively multiplexed, optical and near-infrared spectrograph. Exploiting prime focus, 2394 reconfigurable fibers will be distributed over 1.3 deg field of view. The spectrograph has been designed with 3 arms blue, red, cameras to simultaneously observe spectra from 380nm 1260nm in one exposure at resolution ~1.6-2.7A. An international collaboration developing this...
Abstract γ‐Glutamyltranspeptidase (GGT) is overexpressed in several types of cancer. Existing GGT‐targeting fluorescence probes can image these cancers, but the fluorescent hydrolysis product leaks from target cancer cells during prolonged incubation or fixation. Here, we present a functionalized probe for GGT, 4‐CH 2 F‐HMDiEtR‐gGlu, which designed to generate an azaquinone methide intermediate activation by GGT; this reacts with intracellular nucleophiles adduct that trapped inside cells,...
Osteoarthritis (OA), the most common aging-related joint disease, is caused by an imbalance between extracellular matrix synthesis and degradation. Here, we discover that both strands of microRNA-455 (miR-455), -5p -3p, are up-regulated Sox9, essential transcription factor for cartilage differentiation function. Both miR-455-5p -3p highly expressed in human chondrocytes from normal articular mouse primary chondrocytes. We generate miR-455 knockout mice, find degeneration mimicking OA...
The biological activities of vitamin D3, 25–hydroxyvitamin and 1,2 5–dihydroxyvitamin D3 given each day ip to rats have been compared. Under these conditions, 1,25–dihydroxyvitamin is about 10 times more active than in the elevation serum phosphorus calcification bone on a low diet. It also 5 maintenance calcium stimulation growth equals its effect diet, but 1/5 as antirachitic activity In addition, not or tends produce hypercalcemia even at doses high (Endocrinology92: 417, 1973)