A5060239175- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Plant Pathogens and Fungal Diseases
- Yeasts and Rust Fungi Studies
- Advanced Glycation End Products research
- Alcoholism and Thiamine Deficiency
- Vitamin K Research Studies
- Plant Disease Resistance and Genetics
- Folate and B Vitamins Research
- Alcohol Consumption and Health Effects
- Fungal and yeast genetics research
- Mycotoxins in Agriculture and Food
- Carbohydrate Chemistry and Synthesis
- GDF15 and Related Biomarkers
- Polysaccharides and Plant Cell Walls
- Glycosylation and Glycoproteins Research
- Genetics and Neurodevelopmental Disorders
- Amino Acid Enzymes and Metabolism
- Infections and bacterial resistance
- Diet and metabolism studies
- Diabetes and associated disorders
- Mycorrhizal Fungi and Plant Interactions
- Nuclear Receptors and Signaling
- Genomic variations and chromosomal abnormalities
- Congenital heart defects research
Shonan University of Medical Sciences
2023-2024
Tokyo Metropolitan Matsuzawa Hospital
2021
Tokyo Metropolitan Institute of Medical Science
2010-2021
Meiji Pharmaceutical University
2002-2021
Tokyo Institute of Psychiatry
2011
Chiba Cancer Center
2007-2010
Hisamitsu Pharmaceutical (Japan)
2008
Saitama Medical University
2005-2007
Vitamin K2 is a critical nutrient required for blood coagulation. It also plays key role in bone homeostasis and clinically effective therapeutic agent osteoporosis. We previously demonstrated that vitamin transcriptional regulator of marker genes osteoblastic cells it may potentiate formation by activating the steroid xenobiotic receptor, SXR. To explore SXR-mediated signaling network homeostasis, we identified up-regulated both prototypical SXR ligand, rifampicin, using oligonucleotide...
<h3>Context</h3> Various factors are involved in the pathogenesis of schizophrenia. Accumulation advanced glycation end products, including pentosidine, results from carbonyl stress, a state featuring an increase reactive compounds (RCOs) and their attendant protein modifications. Vitamin B<sub>6</sub>is known to detoxify RCOs, products. Glyoxalase I (GLO1) is one enzymes required for cellular detoxification RCOs. <h3>Objectives</h3> To examine whether plasma levels pentosidine serum vitamin...
Abstract Vitamin K is known as a critical nutrient required for bone homeostasis and blood coagulation, it clinically used therapeutic agent osteoporosis in Japan. Besides its enzymatic action cofactor of vitamin K-dependent γ-glutamyl carboxylase (GGCX), we have previously shown that 2 transcriptional regulator marker genes extracellular matrix-related genes, by activating the steroid xenobiotic receptor (SXR). To explore novel osteoblastic cells, identified up-regulated isoform...
Accumulating evidence suggests that advanced glycation end products, generated as a consequence of facilitated carbonyl stress, are implicated in the development variety diseases. These diseases include neurodegenerative illnesses, such Alzheimer disease. Pyridoxamine is one 3 forms vitamin B6, and it acts by combating stress inhibiting formation AGEs. Depletion pyridoxamine due to enhanced eventually leads decrease other namely pyridoxal pyridoxine. We previously reported higher levels...
The aim of this clinical trial was to obtain proof concept for high-dose pyridoxamine as a novel treatment schizophrenia with enhanced carbonyl stress.Ten Japanese patients high plasma pentosidine, which is representative biomarker stress, were recruited in 24-week, open (ranging from 1200 2400 mg/day) administered using conventional antipsychotic regimen. Main outcomes the total change Positive and Negative Syndrome Scale score Brief Psychiatric Rating baseline end at week 24 (or...
Summary The 22q11.2 deletion is the most prominent known genetic risk factor for schizophrenia, but its penetrance at approximately 50% suggesting that additional factors are required disease progression. We examined a woman with schizophrenia this such factors. She had high plasma pentosidine levels (‘carbonyl stress’) and frameshift mutation in responsible gene, GLO1. also constant exotropia, so we PHOX2B gene associated both strabismus, detected 5-alanine deletion. propose combination of...
Trichosporon asahii is the most clinically important pathogenic yeast in genus Trichosporon, as this species causes both deep-seated infection and summer-type hypersensitivity pneumonitis. We isolated 29 T. colonies from environmental samples using polymerase chain reaction (PCR) dichloran rose bengal chloramphenicol (DRBC) medium. Our results suggest that common nature.
ABSTRACT Trichosporon asahii , which is distributed in the environment, major causative agent of opportunistic infection trichosporonosis, and it also causes summer-type hypersensitivity pneumonitis (SHP). Random amplification polymorphic DNA analysis was used to determine intraspecies diversity 39 T. isolates from clinical specimens, SHP patients' houses, environmental materials. The three primers revealed 46 bands. A phenogram generated by unweighted pair-group method with arithmetic mean....
Cryptococcus humicola, as currently defined, shows intraspecific rRNA gene sequence differences. Three strains of this species produced arthroconidia on cornmeal agar and belonged to the genus Trichosporon in a molecular phylogeny. They clustered with possessing Q10 major ubiquinone were serotype I. Sequence analyses clearly revealed that they two new species. The names dermatis sp. nov. (= CBS 2043T) debeurmannianum 1896T) are proposed for these strains.
The pathogenic yeast Trichosporon asahii is the major causative agent of deep-seated trichosporonosis in immunocompromised patients. Although infection by this microorganism becoming increasingly frequent, information related to its pathogenicity and virulence factors still limited. Therefore, we investigated phenotypic switching colony morphology, production extracellular enzymes as a factor. Sixty-one clinical isolates T. produced four different morphological types on Sabouraud dextrose...
Our previous study showed that enhanced carbonyl stress is closely related to schizophrenia. The endogenous secretory receptor for advanced glycation end-products (esRAGE) a splice variant of the AGER gene and one soluble forms RAGE. esRAGE considered be key molecule alleviating burden by entrapping (AGEs). In current study, we conducted genetic association analyses focusing on AGER, in which compared 212 schizophrenic patients 214 control subjects. We also levels among subgroup 104 89...
Microbial pathogens are known to express molecules that interact with host proteins, leading invasion and colonization. For example, some pathogenic microorganisms proteins bind enhance the activity of plasminogen. In this way, utilize fibrinolytic system promote invasion. We found triosephosphate isomerase (TPI), a glycolytic enzyme produced by Staphylococcus aureus, bound mannooligosaccharides from capsulated fungus Cryptococcus neoformans human plasminogen, suggesting TPI is moonlighting...
Trichosporon asahii is a pathogenic basidiomycetous yeast. Individual strains of T. have different colony morphologies. However, it not clear whether cell surface phenotypes differ among the Here we characterized hydrophobicity and analysed carbohydrate contents polysaccharides in clinical isolates with various Among three distinctive morphologies obtained from one isolate, white-type morphology exhibited higher hydrophobicity. The heat-killed cells was greatly reduced after periodate...
Trichosporon asahii is a pathogenic yeast that causes trichosporonosis, deep-seated infection, in immunocompromised hosts. Pathogenic factors involved this infection have not been investigated detail, but morphological phenotype switching thought to be important for T. pathogenesis. Therefore, we analyzed adhesion, which may key early step after switching. clinical isolates show several colony morphologies. In study, colonies showing white-farinose (W), off-white-smooth (O), off-white-rugose...
The structure of a cell‐wall polysaccharide containing antigen II from Trichosporon asahii was investigated. A purified glucuronoxylomannan (GXM) found to contain O ‐ acetyl groups that contribute the serological reactivity. GXM analyzed by partial acid hydrolysis, methylation analysis, controlled Smith degradation, NMR studies, and fluorophore‐assisted carbohydrate electrophoresis. has an α‐(1→3)‐ d ‐mannan backbone with β‐ ‐glucopyranosyluronic residue bound O‐2 mannopyranosyl same number...
Genetic research of schizophrenia (SCZ) based on the nuclear genome model (NGM) has been one most active areas in psychiatry for past two decades. Although this effort is ongoing, current situation molecular genetics SCZ seems disappointing or rather perplexing. Furthermore, a prominent discrepancy between persistence disease at relatively high prevalence and low reproductive fitness patients creates paradox. Heterozygote advantage works to sustain frequency putative susceptibility gene...
Candida species are opportunistic fungal pathogens that cause superficial or invasive infections. Recently, the incidence of infection by non-Candida albicans species, especially glabrata, has increased. In this study, we analyzed adhesion and cytotoxicity various spp. part normal human microbiota. C. adheres well to cell culture plates cultured cells. glabrata selectively epithelial cells rather than plates. parapsilosis insufficiently confluent monolayers lung A549 keratinocyte HaCaT We...
Trichosporon asahii is the major causative agent of deep-seated trichosporonosis. The virulence factors this yeast pathogen remain uncharacterized. To investigate pathogenicity T. asahii, we focused on interactions between surface molecules and host biomolecules. We examined ability to bind human plasminogen using clinical isolates asahii. Living cells accelerated conversion plasmin in a dose-dependent manner presence tissue activator. Extracts from lithium chloride contained...
ABSTRACT Here, we report the draft genome sequence of Trichosporon domesticum JCM 9580, isolated from house a patient with summer-type hypersensitivity pneumonitis (SHP) in Japan. This genomic information will help elucidate mechanisms development SHP.