A5028104920- Wnt/β-catenin signaling in development and cancer
- Neurotransmitter Receptor Influence on Behavior
- Peroxisome Proliferator-Activated Receptors
- Metabolism and Genetic Disorders
- Folate and B Vitamins Research
- Genomics, phytochemicals, and oxidative stress
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Receptor Mechanisms and Signaling
- Lipid Membrane Structure and Behavior
- Cannabis and Cannabinoid Research
- Tryptophan and brain disorders
- Pancreatic function and diabetes
- Glycosylation and Glycoproteins Research
- Sphingolipid Metabolism and Signaling
- Caveolin-1 and cellular processes
- Cardiomyopathy and Myosin Studies
- Ion channel regulation and function
- Studies on Chitinases and Chitosanases
- Hippo pathway signaling and YAP/TAZ
- Genetics and Neurodevelopmental Disorders
- Sulfur Compounds in Biology
- Erythrocyte Function and Pathophysiology
RIKEN Center for Brain Science
2019-2021
Betaine is known to act against various biological stresses and its levels were reported be decreased in schizophrenia patients. We aimed test the role of betaine pathophysiology, evaluate potential as a novel psychotherapeutic.Using Chdh (a gene for synthesis)-deficient mice betaine-supplemented inbred mice, we assessed psychiatric psychotherapeutic, by leveraging metabolomics, behavioral-, transcriptomics DNA methylation analyses.The Chdh-deficient revealed remnants behaviors along with...
Article28 October 2019Open Access Source DataTransparent process Excess hydrogen sulfide and polysulfides production underlies a schizophrenia pathophysiology Masayuki Ide Laboratory of Molecular Psychiatry, RIKEN Center for Brain Science, Wako, Saitama, Japan Department Division Clinical Medicine, Faculty University Tsukuba, Ibaraki, Search more papers by this author Tetsuo Ohnishi Manabu Toyoshima Shabeesh Balan orcid.org/0000-0002-1098-1290 Motoko Maekawa Chie Shimamoto-Mitsuyama Yoshimi...
The disturbed integrity of myelin and white matter, along with dysregulation the lipid metabolism, may be involved in schizophrenia pathophysiology. Considering crucial role sphingolipids neurodevelopment, particularly oligodendrocyte differentiation myelination, we examined sphingolipid dynamics pathophysiology schizophrenia. We performed targeted mass spectrometry-based analysis from cortical area corpus callosum postmortem brain samples patients controls. observed lower...
Structural changes in the corpus callosum have been reported schizophrenia; however, underlying molecular mechanism remains unclear. As is high lipid content, we analyzed contents of corpora callosa from 15 patients with schizophrenia and age- sex-matched controls using liquid chromatography coupled to tandem mass spectrometry identified combinations associated schizophrenia. Real-time quantitative polymerase chain reaction analyses extended samples (schizophrenia, n = 95; control, 91)...
Abstract Fatty acid binding protein 7 (FABP7) is an intracellular fatty chaperon that highly expressed in astrocytes, oligodendrocyte-precursor cells, and malignant glioma. Previously, we reported FABP7 regulates the response to extracellular stimuli by controlling expression of caveolin-1, important component lipid raft. Here, explored detailed mechanisms underlying regulation caveolin-1 using primary cultured FABP7-KO astrocytes as a model loss function NIH-3T3 cells gain function. We...
Autism spectrum disorder is a neurodevelopmental characterized by difficulties in social communication and interaction, as well repetitive characteristic patterns of behaviour. Although the pathogenesis autism unknown, being overweight or obesity during infancy low weight at birth are known risks, suggesting metabolic aspect. In this study, we investigated adipose tissue development pathophysiological factor examining serum levels adipokines other markers children (n = 123) typically...
Abstract We previously identified quantitative trait loci (QTL) for prepulse inhibition (PPI), an endophenotype of schizophrenia, on mouse chromosome 10 and reported Fabp7 as a candidate gene from analysis F2 mice inbred strains with high (C57BL/6N; B6) low (C3H/HeN; C3H) PPI levels. Here, we reanalyzed the QTLs increased marker density. The highest logarithm odds score (26.66) peaked at synonymous coding splice-site variant, c.753G>A (rs257098870), in Cdh23 10; c.753G (C3H) allele...
Article3 March 2021Open Access Transparent process Cooperation of LIM domain-binding 2 (LDB2) with EGR in the pathogenesis schizophrenia Tetsuo Ohnishi Corresponding Author [email protected] orcid.org/0000-0002-6696-9725 Laboratory for Molecular Psychiatry, RIKEN Center Brain Science, Wako, JapanThese authors contributed equally to this work Search more papers by author Yuji Kiyama orcid.org/0000-0001-5415-3473 Division Neuronal Network, Institute Medical University Tokyo, Japan Biochemistry...
ABSTRACT Betaine is known to act against various biological stresses and its levels were reported be decreased in schizophrenia patients. Using Chdh (a gene for betaine synthesis)-deficient mice betaine-supplemented inbred mice, we assessed the role of psychiatric pathophysiology, potential as a novel psychotherapeutic, by leveraging metabolomics, behavioral-, transcriptomics DNA methylation analyses. The -deficient revealed remnants behaviors along with schizophrenia-related molecular...
Abstract We previously identified quantitative trait loci (QTL) for prepulse inhibition (PPI), an endophenotype of schizophrenia, on mouse chromosome 10 and reported Fabp7 as a candidate gene from analysis F2 mice inbred strains with high (C57BL/6N; B6) low (C3H/HeN; C3H) PPI levels. Here, we reanalyzed the QTLs increased marker density. The highest LOD score (26.66) peaked at synonymous coding splice-site variant, c.753G>A (rs257098870), in Cdh23 10; c.753G (C3H) allele showed...