A5063903743- Posttraumatic Stress Disorder Research
- Radioactive contamination and transfer
- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Risk Perception and Management
- Traumatic Brain Injury Research
- Tryptophan and brain disorders
- Schizophrenia research and treatment
- Disaster Response and Management
- Suicide and Self-Harm Studies
- Signaling Pathways in Disease
- Bipolar Disorder and Treatment
- Diet and metabolism studies
- Neuropeptides and Animal Physiology
- Neuroinflammation and Neurodegeneration Mechanisms
- Ion channel regulation and function
- Heart Rate Variability and Autonomic Control
- Genetics and Neurodevelopmental Disorders
- Metabolomics and Mass Spectrometry Studies
- Genetic Associations and Epidemiology
- Bioinformatics and Genomic Networks
- Advanced Neuroimaging Techniques and Applications
- Protein Kinase Regulation and GTPase Signaling
- PI3K/AKT/mTOR signaling in cancer
- Homelessness and Social Issues
Tohoku University
2020-2025
National Research Institute for Earth Science and Disaster Resilience
2025
Tohoku University Hospital
2022-2024
Fukushima Medical University
2015-2024
National Research Institute of Fire and Disaster
2022
National Institute of Mental Health
2015
Background Following the Great East Japan Earthquake on March 11, 2011, nuclear disaster at Fukushima Daiichi Nuclear Power Plant has continued to affect mental health status of residents in evacuation zone. To examine evacuee after accident, we conducted Mental Health and Lifestyle Survey as part ongoing Management Survey. Methods We measured using Kessler 6-item psychological distress scale (K6) a total 73,569 (response rate: 40.7%) evacuees aged 15 over who lived zone Prefecture. then...
Betaine is known to act against various biological stresses and its levels were reported be decreased in schizophrenia patients. We aimed test the role of betaine pathophysiology, evaluate potential as a novel psychotherapeutic.Using Chdh (a gene for synthesis)-deficient mice betaine-supplemented inbred mice, we assessed psychiatric psychotherapeutic, by leveraging metabolomics, behavioral-, transcriptomics DNA methylation analyses.The Chdh-deficient revealed remnants behaviors along with...
Article28 October 2019Open Access Source DataTransparent process Excess hydrogen sulfide and polysulfides production underlies a schizophrenia pathophysiology Masayuki Ide Laboratory of Molecular Psychiatry, RIKEN Center for Brain Science, Wako, Saitama, Japan Department Division Clinical Medicine, Faculty University Tsukuba, Ibaraki, Search more papers by this author Tetsuo Ohnishi Manabu Toyoshima Shabeesh Balan orcid.org/0000-0002-1098-1290 Motoko Maekawa Chie Shimamoto-Mitsuyama Yoshimi...
BackgroundWe aimed to determine the similarities and differences in roles of genic regulatory copy number variations (CNVs) bipolar disorder (BD), schizophrenia (SCZ), autism spectrum (ASD).MethodsBased on high-resolution CNV data from 8708 Japanese samples, we performed our knowledge largest cross-disorder analysis CNVs BD, SCZ, ASD.ResultsIn CNVs, found an increased burden smaller (<100 kb) exonic deletions which contrasted with highest larger (>500 SCZ/ASD. Pathogenic linked...
Schizophrenia is one of the major psychiatric disorders, and lipids have focused on important roles in this disorder. In fact, related to various functions brain. Previous studies indicated that phospholipids, particularly ones containing polyunsaturated fatty acyl residues, are deficient postmortem brains from patients with schizophrenia. However, due difficulties handling human brains, large size complex structures brain, there little agreement regarding qualitative quantitative...
Objective: CHRNA7, coding α-7 nicotinic acetylcholine receptor (α7 nAChR), is involved in cognition through interneuron modulation of dopamine and glutamate signaling. CHRNA7 its partially duplicated chimeric gene CHRFAM7A have been implicated schizophrenia linkage association studies. Method: Expression mRNA was measured the postmortem prefrontal cortex more than 700 subjects, including patients with schizophrenia, bipolar disorder, major depression, normal comparison subjects. The effects...
Cytogenomic mutations and chromosomal abnormality are implicated in the neuropathology of several brain diseases. Cell heterogeneity tissues makes their detection validation difficult, however. In present study, we analyzed gene dosage alterations DNA schizophrenia patients compared those with copy number variations (CNVs) identified as well Asian lymphocyte attempted to obtain hints at pathological contribution cytogenomic instability schizophrenia. Brain was extracted from postmortem...
In schizophrenia (SCZ), neurons in the brain tend to undergo gross morphological changes, but related molecular mechanism remains largely elusive. Using Kif3b+/- mice as a model with SCZ-like behaviors, we found that high-betaine diet can significantly alleviate schizophrenic traits neuronal morphogenesis and behaviors. According deficiency transport of collapsin response mediator protein 2 (CRMP2) by KIF3 motor, identified significant reduction lamellipodial dynamics developing cause...
Abstract Aim As it is difficult to examine the mental health of disaster victims immediately after a through rigorous procedures required for academic papers, overall state not well understood. Therefore, this study aimed investigate actual needs during transition from acute and subacute phases chronic phase 2024 Noto Peninsula earthquake (NPE). Methods We obtained Emergency Medical Information System (EMIS) data period ∼1 month Disaster Psychiatric Assistance Team support outside prefecture...
// Keisuke Nishiura 1,* , Naoki Ichikawa-Tomikawa Kotaro Sugimoto 1 Yasuto Kunii 2,3 Korehito Kashiwagi Mizuko Tanaka Yuichi Yokoyama 4 Mizuki Hino 2 Takashi Sugino 5 Hirooki Yabe Hitoshi Takahashi Akiyoshi Kakita Tetsuya Imura 1,6 and Hideki Chiba Department of Basic Pathology, Fukushima Medical University School Medicine, Fukushima, Japan Neuropsychiatry, 3 Psychiatry, Aizu Center, University, Brain Research Institute, Niigata Niigata, Diagnostic Shizuoka Cancer Shizuoka, 6 Surgical Kyoto...
Recent evidence from alcohol and trauma studies suggests that disasters are associated with increases in the consumption of alcohol. The Great East Japan Earthquake nuclear disaster have continued to affect mental health evacuees Fukushima. This study aimed extend these findings by examining relationship between drinking behaviors risk illness after compound disaster.We conducted Mental Health Lifestyle Survey 56,543 evacuees. Kessler's K6 was used assess illness, logistic regression models...
High-sugar diet in adolescence induces neural angiopathy and multiple psychiatric endophenotypes with impaired glucose logistics.
We investigated the psychometric properties of Japanese version Posttraumatic Stress Disorder Checklist–Stressor Specific Version (PCL-S) using baseline data from Fukushima Health Management Survey. A total 26,332 men and 33,516 women aged 16 above participated in this study. Participants lived evacuation zone Japan experienced Great East Earthquake nuclear power plant (NPP) incident. The PCL-S was used to assess participants’ posttraumatic stress disorder (PTSD) symptoms. In addition, we...
Abstract Aim The etiology of bipolar disorder (BD) remains unknown; however, lipid abnormalities in BD have received increasing attention recent years. In this study, we examined the expression levels enzyme proteins associated with metabolic pathway phosphoinositides (PIs) and their downstream effectors, protein kinase B (Akt1) glycogen synthase 3β (GSK3β), which been assumed to be targets mood stabilizers such as lithium, postmortem brains patients BD. Methods phosphatidylinositol...
Abstract The etiology of schizophrenia includes phospholipid abnormalities. Phospholipids are bioactive substances essential for brain function. To analyze differences in the quantity and types phospholipids present tissue patients with schizophrenia, we performed a global analysis multiple samples using liquid chromatography electrospray ionization mass/mass spectrometry (LC-ESI/MS/MS) imaging mass (IMS). We found significantly decreased 16:0/20:4-phosphatidylinositol (PI) levels prefrontal...
Previous studies have indicated associations between several OLIG2 gene single-nucleotide polymorphisms (SNPs) and susceptibility to schizophrenia among Caucasians. Consistent with these findings, postmortem brain diffusion tensor imaging that the schizophrenia-risk-associated allele (A) in SNP rs1059004 predicts lower expression dorsolateral prefrontal cortex (DLPFC) of patients reduced white matter (WM) integrity corona radiata normal brains In an effort replicate association this variant...