Junya Matsumoto
A5061849479- Schizophrenia research and treatment
- Functional Brain Connectivity Studies
- Treatment of Major Depression
- Bipolar Disorder and Treatment
- Advanced Neuroimaging Techniques and Applications
- Mental Health and Psychiatry
- Pharmaceutical Practices and Patient Outcomes
- Clinical practice guidelines implementation
- Health Systems, Economic Evaluations, Quality of Life
- Neuroscience and Neuropharmacology Research
- Mental Health Research Topics
- Signaling Pathways in Disease
- Sinusitis and nasal conditions
- Health Policy Implementation Science
- Receptor Mechanisms and Signaling
- Electroconvulsive Therapy Studies
- Tracheal and airway disorders
- Tryptophan and brain disorders
- Autism Spectrum Disorder Research
- Head and Neck Surgical Oncology
- Traumatic Brain Injury Research
- Mental Health Treatment and Access
- Psychosomatic Disorders and Their Treatments
- Ion channel regulation and function
- Epilepsy research and treatment
National Center of Neurology and Psychiatry
2020-2025
National Institute of Mental Health
2020-2025
Fukushima Medical University
2015-2024
Himeji Red Cross Hospital
2023-2024
Fukuoka University
2022-2023
University of Tokyo Hospital
2022-2023
Akita University
2022-2023
Kyoto University
2018-2023
Tohoku University
2023
Kyushu University
2022-2023
Left–right asymmetry is an important organizing feature of the healthy brain that may be altered in schizophrenia, but most studies have used relatively small samples and heterogeneous approaches, resulting equivocal findings. We carried out largest case–control study structural asymmetries with MRI data from 5,080 affected individuals 6,015 controls across 46 datasets, using a single image analysis protocol. Asymmetry indexes were calculated for global regional cortical thickness, surface...
Xenoestrogens, such as bisphenol A and diethylstilbestrol, are glucuronidated by an isoform of UDP-glucuronosyltransferase named UGT2B1 in the livers adult male rats. In this study, we found that nonylphenol octylphenol also conjugated with glucuronic acid rat liver microsomes. Although activities toward these xenoestrogens were not detected fetal liver, a linear increase enzymatic during neonatal development was observed. At 3 weeks after birth, had reached same level The protein mRNA...
Betaine is known to act against various biological stresses and its levels were reported be decreased in schizophrenia patients. We aimed test the role of betaine pathophysiology, evaluate potential as a novel psychotherapeutic.Using Chdh (a gene for synthesis)-deficient mice betaine-supplemented inbred mice, we assessed psychiatric psychotherapeutic, by leveraging metabolomics, behavioral-, transcriptomics DNA methylation analyses.The Chdh-deficient revealed remnants behaviors along with...
Abstract Differential diagnosis is sometimes difficult in practical psychiatric settings, terms of using the current diagnostic system based on presenting symptoms and signs. The creation a novel objective biomarkers expected to take place. Neuroimaging studies others reported that subcortical brain structures are hubs for various psycho-behavioral functions, while there so far no neuroimaging data-driven clinical criteria overcoming limitations system, which would reflect cognitive/social...
Abstract According to the operational diagnostic criteria, psychiatric disorders such as schizophrenia (SZ), bipolar disorder (BD), major depressive (MDD), and autism spectrum (ASD) are classified based on symptoms. While its cluster of symptoms defines each these disorders, there is also an overlap in between disorders. We hypothesized that similarities differences cortical structural neuroimaging features among T1-weighted magnetic resonance imaging scans were performed for 5,549 subjects...
The habenula is involved in the pathophysiology of depression. However, its small structure limits accuracy segmentation methods, and findings regarding volume have been inconsistent. This study aimed to create a highly accurate model using deep learning, test generalizability clinical magnetic resonance imaging, examine changes healthy participants patients with multicenter included 382 (patients depression: n=234, women 47.0%; participants: n=148, 37.8%). A three-dimensional Residual U-Net...
Schizophrenia is one of the major psychiatric disorders, and lipids have focused on important roles in this disorder. In fact, related to various functions brain. Previous studies indicated that phospholipids, particularly ones containing polyunsaturated fatty acyl residues, are deficient postmortem brains from patients with schizophrenia. However, due difficulties handling human brains, large size complex structures brain, there little agreement regarding qualitative quantitative...
Monopharmacy with antipsychotics and antidepressants is the first-line treatment for schizophrenia major depressive disorder (MDD) in most clinical guidelines, while polypharmacy psychotropic agents of common practice. There are no detailed data on prescription patterns inpatients mental illness reliable diagnoses made by treating psychiatrists. We gathered at discharge from 2177 patients 1238 MDD October 2016 to March 2018. The aged between 60 79 were prescribed lower doses...
Cytogenomic mutations and chromosomal abnormality are implicated in the neuropathology of several brain diseases. Cell heterogeneity tissues makes their detection validation difficult, however. In present study, we analyzed gene dosage alterations DNA schizophrenia patients compared those with copy number variations (CNVs) identified as well Asian lymphocyte attempted to obtain hints at pathological contribution cytogenomic instability schizophrenia. Brain was extracted from postmortem...
Abstract Background Guideline for Pharmacological Therapy Schizophrenia was published by the Japanese Society of Neuropsychopharmacology in 2015. “Effectiveness Guidelines Dissemination and Education psychiatric treatment (EGUIDE)” project aimed to standardize medical practice using quality indicators (QIs) as indices evaluate practice. In this study, we have reported indicator values prescription before beginning guideline lectures EGUIDE ascertain baseline status treating patients with...
<title>Abstract</title> Exploring the neurobiological effects of various treatments for depression is pivotal in elucidating shared and unique mechanisms action that may explain commonalities differences treatment outcomes. The amygdala, consisting subdivisions with distinct roles emotional processing, thought to be implicated pathophysiology depression. However, how alter nuclei-specific resting-state functional connectivity (rs-FC) amygdala remains unclear. Here, we hypothesized restore...
Abstract Background In Japan, the Effectiveness of Guidelines for Dissemination and Education (EGUIDE) psychiatric treatment project was launched in 2016. EGUIDE project, we developed a 2-day education course psychiatrists to learn Japanese guidelines schizophrenia major depressive disorder (MDD) (one day each disorder). this program, also evaluated participants’ prescribing activity (prescription at admission discharge patients with or MDD) assess effectiveness our program. Our previous...
ABSTRACT Schizophrenia causes cognitive dysfunction. The assessment of function is important in the treatment schizophrenia. Wechsler Adult Intelligence Scale (WAIS) used to assess patients with psychiatric disorders. For clinical use, a short form WAIS‐III was developed Japan specifically for schizophrenia, allowing estimation IQ using Similarities and Symbol Search. In present study, we examined whether same tasks could be on WAIS‐IV. subjects were 110 Using methods consistent those...
Abstract Background The creation of a novel diagnostic system using objective biomarkers is expected to take place, due difficulty the current based on symptoms in psychiatry. Aims & Objectives We clustered 5602 subjects brain subcortical volumes and showed four-biotype classification, namely extremely (Brain Biotype [BB] 1: n=110) moderately smaller limbic regions (BB2: n=566), larger basal ganglia (BB3: n=679), normal (BB4: n=4247), being associated with cognitive/social functioning...
Abstract Background Evidence-based clinical practice guidelines (guidelines) are used to help people make well-informed decisions. A previous meta-analysis examining the effect of evidence-based for psychiatric disorders on patient health outcomes in specialist mental care suggested that patients who undergo guideline-adherent treatments report better and faster improvements than treated with treatment-as-usual. Major recommend monotherapy antipsychotics schizophrenia antidepressants major...
Abstract Background Antipsychotics are used in treatment of schizophrenia. Although antipsychotic monotherapy is recommended most guidelines, the prescription rate polypharmacy still high, and rates antipsychotics other concomitant psychotropics different among each institution. detailed causes for these differences not well known, one reasons polypharmacy, including may be associated with severity schizophrenia resistant (TRS). With regard to TRS, institutions a low TRS examination was...
ABSTRACT One of the challenges in diagnosing psychiatric disorders is that results biological and neuroscience research are not reflected diagnostic criteria. Thus, data‐driven analyses incorporating cross‐disease perspectives, regardless category, have recently been proposed. A clustering study based on subcortical volumes 5604 subjects classified into four brain biotypes associated with cognitive/social functioning. Among identified controls patients schizophrenia, bipolar disorder, major...
Memory function impairment is severe in patients with schizophrenia, but improving memory remains challenging. The use of benzodiazepines and anticholinergics, which are not recommended by pharmacological therapy guidelines for has been associated worsened cognitive function. However, it unclear whether better adherence psychiatrists to schizophrenia improved Therefore, we investigated the relationship between psychiatrists' schizophrenia. To evaluate associations function, utilized...
The rate of antipsychotic polypharmacy is high. One risk factor for may be the severity schizophrenia, including treatment-resistant schizophrenia (TRS). We hypothesized that institutions are able to prescribe clozapine present differences in pharmacological treatment even before TRS diagnosed. A total 8155 patients with were divided into clozapine-available institution (CAI) group and clozapine-unavailable (CUI) group. psychotropic prescription rates at discharge compared between two...