A5012816071- Schizophrenia research and treatment
- Tryptophan and brain disorders
- Functional Brain Connectivity Studies
- Bipolar Disorder and Treatment
- Stress Responses and Cortisol
- Advanced Neuroimaging Techniques and Applications
- Mental Health Research Topics
- Neuroinflammation and Neurodegeneration Mechanisms
- Antibiotic Resistance in Bacteria
- Psychosomatic Disorders and Their Treatments
- Gut microbiota and health
- Alzheimer's disease research and treatments
- Cholinesterase and Neurodegenerative Diseases
- Neural dynamics and brain function
- Neuroscience and Music Perception
- Nanoplatforms for cancer theranostics
- Child and Adolescent Psychosocial and Emotional Development
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Diet and metabolism studies
- Suicide and Self-Harm Studies
- Treatment of Major Depression
- Mental Health and Psychiatry
- RNA modifications and cancer
Peking University
2016-2025
Beijing HuiLongGuan Hospital
2016-2025
Peking University People's Hospital
2020-2024
University of Montana
2021-2024
University of Arizona
2020-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Chengdu Military General Hospital
2024
South China Normal University
2024
Wenzhou Medical University
2024
Hunan Normal University
2018-2022
Inflammation caused by either intrinsic or extrinsic toxins results in intestinal barrier dysfunction, contributing to inflammatory bowel disease (IBD) and other diseases.
Left–right asymmetry is an important organizing feature of the healthy brain that may be altered in schizophrenia, but most studies have used relatively small samples and heterogeneous approaches, resulting equivocal findings. We carried out largest case–control study structural asymmetries with MRI data from 5,080 affected individuals 6,015 controls across 46 datasets, using a single image analysis protocol. Asymmetry indexes were calculated for global regional cortical thickness, surface...
Abstract Cholesterol (Chol) fortifies packing and reduces fluidity permeability of the lipid bilayer in vesicles (liposomes)-mediated drug delivery. However, under physiological environment, Chol is rapidly extracted from by biomembranes, which jeopardizes membrane stability results premature leakage for delivered payloads, yielding suboptimal clinic efficacy. Herein, we report a Chol-modified sphingomyelin (SM) via covalently conjugating to SM (SM-Chol), retains condensing ability Chol....
Background: The pandemic of COVID-19 posed an unprecedented threat and cascade challenges to the general public in China, especially outbreak-affected severely city, Wuhan. psychological impact response epidemic disasters as well predisposing factors analysis are desperately needed. Methods: Self-administered questionnaires were distributed online population different regions from January 30 February 13, 2020.The Self-Reporting Questionnaire-20, Patient Health Questionnaire-9 Generalized...
A novel series of clioquinol-moracin hybrids were designed and synthesized by fusing the pharmacophores clioquinol moracin M, their activities as multitarget-directed ligands against Alzheimer's disease evaluated. Biological activity results demonstrated that these possessed significant inhibitory phosphodiesterase 4D (PDE4D) Aβ aggregation well remarkable antioxidant effects excellent blood–brain barrier permeability. The optimal compound, 18d (WBQ5187), exhibited PDE4D potency (IC50 = 0.32...
A series of selenium-containing clioquinol derivatives were designed, synthesized, and evaluated as multifunctional anti-Alzheimer's disease (AD) agents. In vitro examination showed that several target compounds exhibited activities such inhibition metal-induced Aβ aggregation, antioxidative properties, hydrogen peroxide scavenging, the prevention copper redox cycling. parallel artificial membrane permeation assay indicated possessed significant blood-brain barrier (BBB) permeability....
The microbiota–gut–brain axis plays a critical role in the pathogenesis of major depressive disorder (MDD) and related subclinical symptoms. However, studies on gut microbiota MDD are inconsistent, data MDD's effects sleep lacking. This study aimed to analyze composition quality patients with MDD. We performed 16S rRNA sequencing stool samples from 36 45 healthy controls (HC). Sleep was assessed using Pittsburgh Quality Index, severity Hamilton Depression Scale, insomnia Insomnia Severity...
Although the selective and effective clearance of senescent cancer cells can improve treatment, their development is confronted by many challenges. As part efforts designed to overcome these problems, prodrugs, whose design based on senescence-associated β-galactosidase (SA-β-gal), have been developed selectively eliminate cells. However, chemotherapies relying targeted molecular inhibitors as senolytic drugs induce drug resistance. In current investigation, we devised a new strategy for...
The clinical presentation of common symptoms during depressive episodes in bipolar disorder (BD) and major (MDD) poses challenges for accurate diagnosis. Disorder-specific neuroanatomical features may aid the development reliable discrimination between these two conditions. For our sample 16 BD patients, 19 MDD patients 29 healthy volunteers, we adopted vertex-wise cortical based brain imaging techniques to examine thickness surface area, components volume with distinct genetic determinants....
A novel series of quinoline–indole derivatives were synthesized and evaluated as multitarget-directed ligands for the treatment Alzheimer's disease (AD). Biological evaluation revealed that had multifunctional profiles including antioxidant effects, blood–brain barrier (BBB) penetration, biometal chelation, Aβ aggregation modulation, neurotrophic neuroprotective properties. Moreover, several representative target demonstrated hippocampal cell proliferation in living adult mice by...
Although schizophrenia is a brain disorder, increasing evidence suggests that there may be body-wide involvement in this illness. However, direct of structures involved the presumed peripheral-central interaction still unclear. Seventy-nine previously treatment-naïve first-episode patients who were within 2-week antipsychotics initial stabilization, and 41 age- sex-matched healthy controls enrolled study. Group differences subcortical regional measured by MRI subclinical cardiovascular,...
Failure of antipsychotic medications to resolve symptoms in patients with schizophrenia creates a clinical challenge that is known as treatment resistance. The causes resistance are unknown, but it associated earlier age at onset and more severe cognitive deficits. authors tested the hypothesis white matter deficits involved both neurodevelopment severity higher risk resistance.The study sample (N=122; mean age, 38.2 years) included initiation (N=45), whose were responsive (N=40), resistant...
Piwi-interacting RNAs (piRNAs) are the non-coding with 24-32 nucleotides (nt). They exhibit stark differences in length, expression pattern, abundance, and genomic organization when compared to micro-RNAs (miRNAs). There hundreds of thousands unique piRNA sequences each species. Numerous piRNAs have been identified deposited public databases. Since were originally discovered well-studied germline, a few other studies reported presence somatic cells including neurons. This paper reviewed...