A5043164841- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Long-Term Effects of COVID-19
- Advanced MRI Techniques and Applications
- Schizophrenia research and treatment
- Tryptophan and brain disorders
- Infectious Encephalopathies and Encephalitis
- Traumatic Brain Injury and Neurovascular Disturbances
- Intensive Care Unit Cognitive Disorders
- Neonatal and fetal brain pathology
- Fetal and Pediatric Neurological Disorders
- Birth, Development, and Health
- Thermal Regulation in Medicine
- COVID-19 and Mental Health
- Health disparities and outcomes
- Media, Religion, Digital Communication
- Cerebrospinal fluid and hydrocephalus
- Nutritional Studies and Diet
- Tensor decomposition and applications
- Dementia and Cognitive Impairment Research
- Bipolar Disorder and Treatment
- Cardiovascular Disease and Adiposity
- Stress Responses and Cortisol
- Parkinson's Disease Mechanisms and Treatments
- Prenatal Substance Exposure Effects
University of Maryland, Baltimore
2017-2025
Johns Hopkins University
2023
Johns Hopkins Medicine
2023
Efforts to remediate the multiple cognitive function impairments in schizophrenia should consider white matter as one of underlying neural mechanisms.To determine whether altered structural brain connectivity is responsible for 2 core deficits schizophrenia- reduced information processing speed and impaired working memory.This cross-sectional study design took place outpatient clinics from August 1, 2004, 31, 2015. Participants included 166 patients with 213 healthy control individuals....
Abstract The ENIGMA‐DTI (diffusion tensor imaging) workgroup supports analyses that examine the effects of psychiatric, neurological, and developmental disorders on white matter pathways human brain, as well normal variation its genetic associations. seven ENIGMA disorder‐oriented working groups used workflow to derive patterns deficits using coherent coordinated model disease across cohorts worldwide. This yielded largest studies detailing in schizophrenia spectrum disorder (SSD), bipolar...
Post-COVID condition (PCC) is common and often involves neuropsychiatric symptoms. This study aimed to use blood oxygenation level-dependent fMRI (BOLD-fMRI) assess whether participants with PCC had abnormal brain activation during working memory (WM) the could predict cognitive performance, motor function, or psychiatric
Although schizophrenia is a brain disorder, increasing evidence suggests that there may be body-wide involvement in this illness. However, direct of structures involved the presumed peripheral-central interaction still unclear. Seventy-nine previously treatment-naïve first-episode patients who were within 2-week antipsychotics initial stabilization, and 41 age- sex-matched healthy controls enrolled study. Group differences subcortical regional measured by MRI subclinical cardiovascular,...
Failure of antipsychotic medications to resolve symptoms in patients with schizophrenia creates a clinical challenge that is known as treatment resistance. The causes resistance are unknown, but it associated earlier age at onset and more severe cognitive deficits. authors tested the hypothesis white matter deficits involved both neurodevelopment severity higher risk resistance.The study sample (N=122; mean age, 38.2 years) included initiation (N=45), whose were responsive (N=40), resistant...
Abstract Background The aim of this study was to determine whether neurometabolite abnormalities indicating neuroinflammation and neuronal injury are detectable in individuals post–coronavirus disease 2019 (COVID-19) with persistent neuropsychiatric symptoms. Methods All participants were studied proton magnetic resonance spectroscopy at 3 T assess concentrations (point-resolved spectroscopy, relaxation time/echo time = 3000/30 ms) frontal white matter (FWM) anterior cingulate cortex–gray...
Abstract Schizophrenia (SZ) is a severe psychiatric illness associated with an elevated risk for developing Alzheimer’s disease (AD). Both SZ and AD have white matter abnormalities cognitive deficits as core features. We hypothesized that aging in patients may be the development of cerebral deficit patterns similar to those observed AD. identified replicated aging-related increases similarity between The “regional vulnerability index” (RVI) was significantly higher compared healthy controls...
We aimed to compare brain white matter integrity in participants with post-COVID-19 conditions (PCC) and healthy controls.We compared cognitive performance (NIH Toolbox®), psychiatric symptoms diffusion tensor imaging (DTI) metrics between 23 PCC 24 controls. Fractional anisotropy (FA), axial (AD), radial (RD), mean (MD) diffusivities were measured 9 tracts 6 subcortical regions using MRICloud.Compared controls, had similar performance, but greater perceived stress, as well higher FA lower...
Abstract Patients with schizophrenia have patterns of brain deficits including reduced cortical thickness, subcortical gray matter volumes, and cerebral white integrity. We proposed the regional vulnerability index (RVI) to translate results Enhancing Neuro Imaging Genetics Meta‐Analysis studies individual level. calculated RVIs for cortical, subcortical, measurements a multimodality RVI. evaluated RVI as measure sensitive schizophrenia‐specific neuroanatomical symptoms studied timeline...
Abstract Objectives Early tobacco use (before age 11) is linked to poorer cognition and reduced cortical surface area volume in young adolescents. This study examined how socioeconomic status (SES) factors – parental education, household income, economic hardships influenced these associations. Methods Using baseline (N=11,876) year 3 (N=10,414) datasets from the Adolescent Brain Cognitive Development study, we assessed impact of tobacco/nicotine initiation on cognitive scores, volume,...
Abstract Introduction Quantitative longitudinal magnetic resonance imaging and spectroscopy ( MRI /S) is used to assess progress of brain disorders treatment effects. Understanding the significance /S changes requires knowledge inherent technical physiological consistency these measurements. This study examined variance reproducibility commonly quantitative measurements in healthy subjects while controlling parameters. Methods Twenty‐five were imaged three times over 5 days on a Siemens 3T...
Imaging genetic analyses use heritability calculations to measure the fraction of phenotypic variance attributable additive factors. We tested agreement between estimates provided by four methods that are used for in neuroimaging traits. SOLAR-Eclipse and OpenMx iterative maximum likelihood estimation (MLE) methods. Accelerated Permutation inference ACE (APACE) fast permutation (FPHI), employ fast, non-iterative approximation-based performed this evaluation a simulated twin-sibling pedigree...
Abstract Severe mental illnesses (SMI) including major depressive disorder (MDD), bipolar (BD), and schizophrenia spectrum (SSD) elevate accelerated brain aging risks. Cardio‐metabolic disorders (CMD) are common comorbidities in SMI negatively impact health. We validated a linear quantile regression index (QRI) approach against the machine learning “BrainAge” an independent SSD cohort ( N = 206). tested direct additive effects of CMD on 1,618 (604 M/1,014 F, average age 63.53 ± 7.38)...
Abstract Subanesthetic administration of ketamine is a pharmacological model to elicit positive and negative symptoms psychosis in healthy volunteers. We used resting‐state functional MRI (rsPhfMRI) identify cerebral networks affected by compared them the connectivity (FC) schizophrenia. Ketamine can produce sedation we contrasted its effects with anxiolytic drug midazolam. Thirty male volunteers (age = 19–37 years) underwent randomized, three‐way, cross‐over study consisting three imaging...
Abstract A novel mega‐analytical approach that reduced methodological variance was evaluated using a multisite diffusion tensor imaging (DTI) fractional anisotropy (FA) data by comparing white matter integrity in people with schizophrenia to controls. Methodological through regression of captured from quality assurance (QA) and Marchenko–Pastur Principal Component Analysis (MP‐PCA) denoising. N = 192 (119 patients/73 controls) sets were collected at three sites equipped 3T MRI systems: GE...
Reduced cortical gray matter integrity and cognitive abilities are among core deficits in schizophrenia. We hypothesized that higher allostatic load (AL) accounts for exposure to chronic stress is a contributor structural One hundred sixty-seven schizophrenia patients who were on average with normal weight, systolic, diastolic blood pressure 72 healthy controls enrolled the study. Group differences subclinical cardiovascular, metabolic, immune, neuroendocrine biological markers as indexed by...
Abstract Imaging genetic analyses quantify control over quantitative measurements of brain structure and function using coefficients relationship (CR) that code the degree shared genetics between subjects. CR can be inferred through self‐reported relatedness or calculated empirically genome‐wide SNP scans. We hypothesized empirical provides a more accurate assessment than relatedness. tested this in 1,046 participants Human Connectome Project (HCP) (480 M/566 F) recruited from Missouri twin...
Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection is associated with lower plasma glutathione (GSH) levels due to oxidative stress. However, may not reflect brain GSH levels. Individuals post-acute sequelae of COVID-19 (PASC) have a higher prevalence cognitive fatigue, which might be related altered γ-aminobutyric-acid (GABA) Hence, our study aims measure the and GABA in PASC.
Abstract Occupational exposure to hypobaria (low atmospheric pressure) is a risk factor for reduced white matter integrity, increased hyperintensive burden, and decline in cognitive function. We tested the hypothesis that discrete hypobaric will have transient impact on cerebral physiology. Cerebral blood flow, fractional anisotropy of water diffusion matter, hyperintensity volume, concentrations neurochemicals were measured at baseline 24 hr 72 postexposure N = 64 healthy aircrew undergoing...
Neurological and psychiatric illnesses are associated with regional brain deficit patterns that bear unique signatures capture illness-specific characteristics. The Regional Vulnerability Index (RVI) was developed to quantify similarity by comparing individual white matter microstructure, cortical gray thickness subcortical structural volume measures neuroanatomical derived from large-scale meta-analytic studies. We tested the specificity of RVI approach for major depressive disorder (MDD)...
To quantify neuropsychiatric symptoms reported by individuals with Post-Acute Sequelae of COVID-19 (PASC) using the NIH Toolbox® for Assessment Neurological and Behavioral Function (NIHTB) Patient-Reported Outcomes Measurement Information System (PROMIS).30 PASC (20 women, 21-63 years) 27 control (16 25-68 participants completed three NIHTB batteries selected PROMIS tests. Group differences on fully corrected T-scores were evaluated analysis covariance Cohen's d effect sizes. A linear...
Objective To assess the association between peripheral lipid/fat profiles and cerebral gray matter (GM) white (WM) in healthy Old Order Amish (OOA). Methods Blood lipids, abdominal adiposity, liver lipid contents, microstructure were assessed OOA ( N = 64, 31 males/33 females, ages 18‐77). Orthogonal factors extracted from imaging adiposity measures. GM assessment used Human Connectome Project protocol to measure whole‐brain average cortical thickness. Diffusion‐weighted was derive WM...