A5084763633- Traumatic Brain Injury Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Arrest and Resuscitation
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Neonatal and fetal brain pathology
- Advanced MRI Techniques and Applications
- Cerebral Palsy and Movement Disorders
- Posttraumatic Stress Disorder Research
- Suicide and Self-Harm Studies
- Trauma and Emergency Care Studies
- Psychosomatic Disorders and Their Treatments
- Intimate Partner and Family Violence
- Child Abuse and Trauma
- Resilience and Mental Health
- Health, Environment, Cognitive Aging
- Atomic and Subatomic Physics Research
- Homicide, Infanticide, and Child Abuse
- Cognitive Functions and Memory
- Dementia and Cognitive Impairment Research
- Neural and Behavioral Psychology Studies
- Elder Abuse and Neglect
- Balance, Gait, and Falls Prevention
- Medical Imaging Techniques and Applications
- Automotive and Human Injury Biomechanics
University of Utah
2010-2025
VA Salt Lake City Healthcare System
2018-2025
George E. Wahlen Department of VA Medical Center
2018-2025
Michael E. DeBakey VA Medical Center
2013-2024
Baylor College of Medicine
2015-2024
Ben Taub Hospital
2019-2024
Icahn School of Medicine at Mount Sinai
2024
Anna Needs Neuroblastoma Answers
2024
University of Iowa
2021-2023
The University of Texas Health Science Center at Houston
2008-2023
This article addresses the need for age-relevant outcome measures traumatic brain injury (TBI) research and summarizes recommendations by inter-agency Pediatric TBI Outcomes Workgroup. The Workgroup's address primary clinical objectives including characterizing course of recovery from TBI, prediction later outcome, measurement treatment effects, comparison outcomes across studies. Consistent with other Common Data Elements (CDE) Workgroups, Workgroup adopted standard three-tier system in its...
To evaluate the effects of mild to moderate blast-related traumatic brain injury (TBI) on microstructure white matter (WM) and neurobehavioral outcomes, we studied 37 veterans service members (mean age 31.5 years, SD = 7.2; post-injury interval 871.5 days; 343.1), whose report acute neurological status was consistent with sustaining TBI due blast while serving in Iraq or Afghanistan. Fifteen without a history exposure 31.4 5.4) served as comparison group, including seven subjects...
Diffusion tensor imaging (DTI) is a recent technique that assesses the microstructure of cerebral white matter (WM) based on anisotropic diffusion (i.e., water molecules move faster in parallel to nerve fibers than perpendicular them). Fractional anisotropy (FA), which ranges from 0 1.0, increases with myelination WM tracts and sensitive diffuse axonal injury (DAI) adults traumatic brain (TBI). However, previous DTI studies pediatric TBI were case reports without detailed outcome measures....
In vivo MRI volumetric analysis enables investigators to evaluate the extent of tissue loss following traumatic brain injury (TBI). However, studies pediatric TBI are sparse, and there have been no date in children examining specific subregions prefrontal temporal lobes. this study, volumetry was used volume differences whole brain, prefrontal, temporal, posterior regions moderate severe as compared uninjured similar age demographic characteristics. The group had significantly reduced...
Frontal, limbic and temporal regions of the brain important in emotion perception executive functioning also have been implicated etiology maintenance depression; yet, relationships among these topics remain poorly understood. The present study evaluated 21 depressed women 20 nondepressed controls. Depressed performed significantly worse than controls accuracy inhibitory control, an aspect functioning, whereas groups did not differ other cognitive tests assessing memory, visual-spatial,...
<h3>BACKGROUND AND PURPOSE:</h3> DTI of normal-appearing WM as evaluated by conventional MR imaging in mTBI has the potential to identify important regional abnormalities that relate PCS. VBA was used examine changes acute mTBI. <h3>MATERIALS METHODS:</h3> assessed between 1 and 6 days postinjury with voxel-based analyses 10 adolescent patients age-matched control participants. In addition group, analysis brain pathology across all mTBI, 2 linear regressions were performed. These...
Objective To investigate the relation of white matter integrity using diffusion tensor imaging (DTI) to cognitive and functional outcome moderate severe traumatic brain injury (TBI) in children. Design Prospective observational study children who had sustained TBI a comparison group orthopedic (OI). Participants Thirty-two 36 with OI were studied. Methods Fiber tracking analysis DTI acquired at 3-month postinjury assessment global function within 2 weeks imaging. Global was assessed Glasgow...
To accelerate data sharing and research on traumatic brain injury (TBI), several federal agencies have been collaborating to support the development implementation of common elements (CDEs). The first recommendations for CDEs were made in 2010, well suited hospital-based studies acute TBI adults. broaden utility CDEs, experts asked update make them relevant all ages, levels severity, phases recovery. second version (v.2) was organized around four major study types: 1) epidemiological...
Background: Atrophy of the corpus callosum (CC) is a documented consequence moderate-to-severe traumatic brain injury (TBI), which has been expressed as volume loss using quantitative magnetic resonance imaging (MRI). Other advanced modalities such diffusion tensor (DTI) have also detected white matter microstructural alteration following TBI in CC. The manner and degree to macrostructural changes develop over time pediatric TBI, their relation measure processing speed focus this...
Compromised memory functioning is one of the commonly reported cognitive sequelae seen following mild traumatic brain injury (mTBI). Diffusion tensor imaging (DTI) has been shown to be sufficiently sensitive at detecting early microstructural pathological alterations after mTBI. Given its location and shape, cingulate, which comprised cingulate gyrus (gray matter) cingulum bundles (white matter), selectively vulnerable In this study we examined integrity using DTI, relationship between...
There is significant heterogeneity in outcomes following mild traumatic brain injury (mTBI). While several host factors (age, gender, and preinjury psychiatric history) have been investigated, the influence of psychological resilience mood status conjunction with TBI remains relatively unexplored. Euthymic high are potentially protective against anxiety postconcussion symptoms, but their relative contributions currently unknown. This prospective study obtained estimates measures addition to...
Although most patients with mild traumatic brain injury (mTBI) recover within 3 months, a subgroup of experience persistent symptoms. Yet, the prevalence and predictors dysfunction in mTBI remain poorly understood. In longitudinal study, we evaluated symptomatic cognitive adolescents young adults mTBI, compared two control groups—patients orthopedic injuries healthy uninjured individuals. Outcomes were assessed at months post-injury. Poor outcome was defined as exhibiting symptom score...
Through a partnership with the National Institute of Neurological Disorders and Stroke (NINDS), Institutes Health, Department Defense, development Sport-Related Concussion (SRC) Common Data Elements (CDEs) was initiated. The aim this collaboration to increase efficiency effectiveness clinical research studies treatment outcomes, data quality, facilitate sharing across studies, reduce study start-up time, more effectively aggregate information into metadata results, educate new investigators....
Objective: The objective of the study is to measure plasma and exosomal levels tau, phosphorylated tau (p-tau), amyloid beta (Aβ) in Veterans with historical mild traumatic brain injury (mTBI) chronic neuropsychological symptoms.Methods: Tau, p-tau, Aβ40, Aβ42 were measured by ultrasensitive immunoassay exosomes from 195 enrolled Chronic Effects Neurotrauma Consortium Multicenter Observational Study. Protein biomarkers compared among groups without mTBI loss consciousness (LOC) or...
Abstract The ENIGMA‐DTI (diffusion tensor imaging) workgroup supports analyses that examine the effects of psychiatric, neurological, and developmental disorders on white matter pathways human brain, as well normal variation its genetic associations. seven ENIGMA disorder‐oriented working groups used workflow to derive patterns deficits using coherent coordinated model disease across cohorts worldwide. This yielded largest studies detailing in schizophrenia spectrum disorder (SSD), bipolar...
Traumatic brain injury (TBI) was common among US service members deployed to Iraq and Afghanistan. Although there is some evidence suggest that TBI increases the risk of cardiovascular disease (CVD), prior reports were predominantly limited cerebrovascular outcomes. The potential association with CVD has not been comprehensively examined in post-9/11-era veterans.To determine between subsequent veterans.This a retrospective cohort study conducted from October 1, 1999, September 30, 2016....
While closed head injury frequently results in damage to the frontal and temporal lobes, deep cortical structures, such as hippocampus, amygdala, basal ganglia, has also been reported. Five central structures (hippocampus, globus pallidus, putamen, caudate) were examined 16 children (eight males, eight females; aged 9–16y), imaged 1 10 years after moderate‐to‐severe traumatic brain (TBI), individually‐matched uninjured children. Analysis revealed significant volume loss amydala, pallidus of...
Abstract The objective was to assess the nature, rate, predictive factors, and neuroimaging correlates of novel (new‐onset) depressive disorders, both definite subclinical, after traumatic brain injury (TBI). Children with TBI from consecutive admissions were enrolled studied psychiatric interviews soon (baseline), again 6 months post‐injury. Novel definite/subclinical disorders at 6‐month follow up occurred in 11% ( n = 15) children subsets non‐anxious depression 9) anxious 6) identified....
Generalized whole brain volume loss has been well documented in moderate-to-severe traumatic injury (TBI), as diffuse cerebral atrophy based on magnetic resonance imaging (MRI) volumetric methods where white matter may be more selectively affected than gray matter. However, specific regional differences thickness of the cortical mantle have not previously examined. As such, was assessed using FreeSurfer® software to identify regions significant thinning MRI scans 16 young TBI subjects (age...