A5073612272- Traumatic Brain Injury Research
- Advanced Neuroimaging Techniques and Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Neonatal and fetal brain pathology
- Advanced MRI Techniques and Applications
- Functional Brain Connectivity Studies
- EEG and Brain-Computer Interfaces
- Cerebral Palsy and Movement Disorders
- Cardiac Arrest and Resuscitation
- Neural dynamics and brain function
- Fetal and Pediatric Neurological Disorders
- Congenital Heart Disease Studies
- Psychosomatic Disorders and Their Treatments
- Obesity, Physical Activity, Diet
- Congenital heart defects research
- Neural and Behavioral Psychology Studies
- Glioma Diagnosis and Treatment
- Atomic and Subatomic Physics Research
- Resilience and Mental Health
- Cardiac Imaging and Diagnostics
- Genomic variations and chromosomal abnormalities
- Birth, Development, and Health
- RNA modifications and cancer
- Hemoglobinopathies and Related Disorders
- Cognitive Functions and Memory
Beijing University of Posts and Telecommunications
2025
Texas Children's Hospital
2015-2024
Baylor College of Medicine
2015-2024
Ben Taub Hospital
2024
Simons Foundation
2018-2021
Pain and Rehabilitation Medicine
2021
Columbia University
2018
Centre Pompidou
2012
Michael E. DeBakey VA Medical Center
2010
Sri Ramachandra Medical Centre
2010
Background: Despite normal CT imaging and neurologic functioning, many individuals report postconcussion symptoms following mild traumatic brain injury (MTBI). This dissociation has been enigmatic for clinicians investigators. Methods: Diffusion tensor tractography of the corpus callosum was performed in 10 adolescents (14 to 19 years age) with MTBI 1 6 days postinjury Glasgow Coma Scale score 15 negative CT, age- gender-equivalent uninjured controls. Subjects were administered Rivermead...
To evaluate the effects of mild to moderate blast-related traumatic brain injury (TBI) on microstructure white matter (WM) and neurobehavioral outcomes, we studied 37 veterans service members (mean age 31.5 years, SD = 7.2; post-injury interval 871.5 days; 343.1), whose report acute neurological status was consistent with sustaining TBI due blast while serving in Iraq or Afghanistan. Fifteen without a history exposure 31.4 5.4) served as comparison group, including seven subjects...
The rise in obesity-related morbidity children and adolescents requires urgent prevention treatment strategies. Currently, only limited data are available on the effects of exercise programs insulin resistance, visceral, hepatic, intramyocellular fat accumulation. We hypothesized that a 12-week controlled aerobic program without weight loss reduces content decreases resistance sedentary Hispanic adolescents. Twenty-nine postpubertal (Tanner stage IV V), adolescents, 15 obese (7 boys, 8...
Diffusion tensor imaging (DTI) is a recent technique that assesses the microstructure of cerebral white matter (WM) based on anisotropic diffusion (i.e., water molecules move faster in parallel to nerve fibers than perpendicular them). Fractional anisotropy (FA), which ranges from 0 1.0, increases with myelination WM tracts and sensitive diffuse axonal injury (DAI) adults traumatic brain (TBI). However, previous DTI studies pediatric TBI were case reports without detailed outcome measures....
<h3>BACKGROUND AND PURPOSE:</h3> DTI of normal-appearing WM as evaluated by conventional MR imaging in mTBI has the potential to identify important regional abnormalities that relate PCS. VBA was used examine changes acute mTBI. <h3>MATERIALS METHODS:</h3> assessed between 1 and 6 days postinjury with voxel-based analyses 10 adolescent patients age-matched control participants. In addition group, analysis brain pathology across all mTBI, 2 linear regressions were performed. These...
Data on the metabolic effects of resistance exercise (strength training) in adolescents are limited.
Objective To investigate the relation of white matter integrity using diffusion tensor imaging (DTI) to cognitive and functional outcome moderate severe traumatic brain injury (TBI) in children. Design Prospective observational study children who had sustained TBI a comparison group orthopedic (OI). Participants Thirty-two 36 with OI were studied. Methods Fiber tracking analysis DTI acquired at 3-month postinjury assessment global function within 2 weeks imaging. Global was assessed Glasgow...
Background: Atrophy of the corpus callosum (CC) is a documented consequence moderate-to-severe traumatic brain injury (TBI), which has been expressed as volume loss using quantitative magnetic resonance imaging (MRI). Other advanced modalities such diffusion tensor (DTI) have also detected white matter microstructural alteration following TBI in CC. The manner and degree to macrostructural changes develop over time pediatric TBI, their relation measure processing speed focus this...
Compromised memory functioning is one of the commonly reported cognitive sequelae seen following mild traumatic brain injury (mTBI). Diffusion tensor imaging (DTI) has been shown to be sufficiently sensitive at detecting early microstructural pathological alterations after mTBI. Given its location and shape, cingulate, which comprised cingulate gyrus (gray matter) cingulum bundles (white matter), selectively vulnerable In this study we examined integrity using DTI, relationship between...
Abstract The purpose of this study was to assess patterns cortical development over time in children who had sustained traumatic brain injury (TBI) as compared with orthopedic (OI), and examine how these related emotional control behavioral dysregulation, two common post‐TBI symptoms. Cortical thickness measured at approximately 3 18 months post‐injury 20 aged 8.2–17.5 years moderate‐to‐severe closed head 21 7.4–16.7 OI. At post‐injury, the TBI group evidenced decreased bilaterally aspects...
Cine balanced steady-state free precession (SSFP), the preferred sequence for ventricular function, demands uninterrupted radio frequency (RF) excitation to maintain during suspended respiration. This is difficult accomplish in sedated children. In this work, we validate a respiratory triggered (RT) SSFP that drives magnetization before commencing retrospectively cardiac gated cine acquisition pediatric population. prospective study was performed on 20 children with congenital heart disease...
The ventrolateral nucleus of the thalamus (VL), based on its connectivity with cerebellum and motor cortex, has long been considered to be involved functions. We show that human VL also plays a prominent role in sensory processing.Structural magnetic resonance imaging diffusion tensor were used localize small lesion restricted right patient contralesional processing deficits. Systematic assessments anatomic brain organization behavioral measurements somatosensory visual conducted at several...
Structural damage to the prefrontal-cingulate network has been implicated in cognitive and neurobehavioral deficits associated with traumatic brain injury (TBI). Forty-six children who had sustained moderate-to-severe TBI 43 extracranial were imaged using diffusion tensor imaging (DTI). Decreased fractional anisotropy (FA) increased apparent coefficient (ADC) values found cingulum bundles bilaterally group. Cingulum ADC was related frontal lesion volume, severity, mechanism. Finally, DTI...
Effects of pediatric traumatic brain injury (TBI) on social problem-solving were examined in a longitudinal study 103 children with moderate-to-severe TBI (n = 52) or orthopedic (OI; n 51) using the Interpersonal Negotiation Strategies task (INS). Children solved age-appropriate hypothetical conflicts, responses for four steps scored by developmental level. The OI group performed better than group, but rate change performance over time did not differ between groups, suggesting improvement...
ABSTRACT The integrity of the fornix using diffusion tensor imaging (DTI) in adolescent participants with acute mild traumatic brain injury (mTBI) compared to a demographically matched control group was examined. Fractional anisotropy (FA) elevated injured group. Performance on Automated Neuropsychological Assessment Metrics (ANAM) lower mTBI. A relation found between performance cognitive tasks and higher FA. potential role as basis memory processing speed deficits mTBI is discussed.
This study examined the use of diffusion tensor imaging in detecting white matter changes frontal lobes following pediatric traumatic brain injury. A total 46 children (ages 8-16 years) with moderate to severe injury and 47 orthopedic underwent 1.5 Tesla magnetic resonance (MRI) at 3 months postinjury. Conventional MRI studies were obtained along imaging. Diffusion metrics, including fractional anisotropy, apparent coefficient, radial diffusivity, compared between groups. Significant group...
To address controversy surrounding the most appropriate comparison group for mild traumatic brain injury (mTBI) research, mTBI patients 12–30 years of age were compared with an extracranial orthopedic (OI) patient and uninjured, typically developing (TD) participant comparable demographic backgrounds. Injured participants underwent subacute (within 96 h) late (3 months) diffusion tensor imaging (DTI); TD controls DTI once. Group differences in fractional anisotropy (FA) mean diffusivity (MD)...
Epilepsy is associated with alterations in the structural framework of cerebral network. The aim this study was to measure potential global metrics network architecture derived from resting state functional MRI capture impact epilepsy on developing brain. Pediatric patients were retrospectively identified with: 1. Focal epilepsy; 2. Brain at 3 Tesla, including MRI; 3. Full scale IQ measured by a pediatric neuropsychologist. cortex parcellated into approximately 700 gray matter nodes....
Radiotherapy for pediatric brain tumors is associated with reduced white matter structural integrity and neurocognitive decline. Superior cognitive outcomes have been reported following proton radiotherapy (PRT) compared to photon (XRT), presumably due improved sparing of normal tissue. This exploratory study examined the relationship between change late effects in tumor survivors treated XRT versus PRT. Pediatric (n = 10) or PRT 12) underwent neuropsychological testing diffusion weighted...
Angelman syndrome is a neurogenetic disorder characterized by severe intellectual disability, absent speech, seizures, and outbursts of laughter. The aim this study was to utilize diffusion tensor imaging (DTI) examine alterations in white matter pathways syndrome, with an emphasis on correlations clinical severity.DTI used the arcuate fasciculus (AF), uncinate (UF), inferior longitudinal (ILF), fronto-occipital (IFOF), corpus callosum (CC). We enrolled 14 children aged 8 17 years (mean age...