A5008516561- Traumatic Brain Injury Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Arrest and Resuscitation
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Autism Spectrum Disorder Research
- Dementia and Cognitive Impairment Research
- Memory and Neural Mechanisms
- Advanced MRI Techniques and Applications
- Genetics and Neurodevelopmental Disorders
- Neonatal and fetal brain pathology
- Psychosomatic Disorders and Their Treatments
- Attention Deficit Hyperactivity Disorder
- Congenital heart defects research
- Automotive and Human Injury Biomechanics
- Neurobiology of Language and Bilingualism
- Alzheimer's disease research and treatments
- Child and Adolescent Psychosocial and Emotional Development
- Cognitive Functions and Memory
- Epilepsy research and treatment
- Resilience and Mental Health
- Genomic variations and chromosomal abnormalities
- Neural and Behavioral Psychology Studies
- Virology and Viral Diseases
- Cerebrospinal fluid and hydrocephalus
University of Utah
2015-2025
Brigham Young University
2012-2024
Provo College
2018
Northwestern University
2002
University of Maryland, College Park
2002
University of San Francisco
2002
LDS Hospital
1993
The cortical underconnectivity theory asserts that reduced long-range functional connectivity might contribute to a neural mechanism for autism. We examined resting-state blood oxygen level–dependent interhemispheric correlation in 53 males with high-functioning autism and 39 typically developing from late childhood through early adulthood. By constructing spatial maps of between homologous voxels each hemisphere, we found significantly specific regions relevance autism: sensorimotor cortex,...
The natural history of brain growth in autism spectrum disorders remains unclear. Cross-sectional studies have identified regional abnormalities volume and cortical thickness autism, although substantial discrepancies been reported. Preliminary longitudinal using two time points small samples specific differences the disorder. To clarify age-related trajectories development, we examined changes within a large mixed cross-sectional sample autistic subjects age- gender-matched typically...
Magnetic resonance imaging (MRI) provides a method to identify and quantify abnormalities resulting from traumatic brain injury (TBI). MRI in children with TBI have not been fully characterized according the frequency, location, quantitative measurement of range pathologies critical for studies neuropsychological outcome. Here, we report findings large, multicenter study childhood TBI, Social Outcomes Brain Injury Kids (SOBIK) study, which compared qualitative neuroimaging 72 complicated...
Abstract This study examined peer relationships in children with traumatic brain injury (TBI) relative to orthopedic injuries (OI), and explored whether differences correlated white matter volumes. Classroom procedures were used elicit perceptions of social behavior, acceptance, friendships for eighty-seven 8- 13-year-old children, 15 severe TBI, 40 complicated mild/moderate 32 OI. Magnetic resonance imaging (MRI) voxel-based morphometry (VBM) investigate volumetric correlates relationship...
ABSTRACT PURPOSE To examine intermethod reliabilities and differences between FreeSurfer the FDA‐cleared congener, NeuroQuant®, both fully automated methods for structural brain MRI measurements. MATERIALS AND METHODS scans from 20 normal control subjects, Alzheimer's disease patients, mild traumatically brain‐injured patients were analyzed with NeuroQuant® FreeSurfer. Intermethod reliability was evaluated. RESULTS Pairwise correlation coefficients, intraclass effect size computed. versus...
Cognitive deficits following ventromedial prefrontal damage (VM-PFD) have been elusive, with most studies reporting primarily emotional and behavioral changes. The present case illustrates the utility of a process approach to assessing cognitive VM-PFD. At age 26, C.D. acquired bilateral VM-PFD, more so in left frontal region, penetrating head injury. Despite exemplary premorbid academic military performances, his subsequent history suggests dramatic occupational social changes, reminiscent...
Radiotherapy for pediatric brain tumors is associated with reduced white matter structural integrity and neurocognitive decline. Superior cognitive outcomes have been reported following proton radiotherapy (PRT) compared to photon (XRT), presumably due improved sparing of normal tissue. This exploratory study examined the relationship between change late effects in tumor survivors treated XRT versus PRT. Pediatric (n = 10) or PRT 12) underwent neuropsychological testing diffusion weighted...
The medial surface areas of the cingulate gyrus (CG) and other midline structures (corpus callosum, thalamus, lateral ventricle) were examined in 27 traumatically brain injured (TBI) 12 age- gender-matched control subjects from an established TBI data base. Significant atrophy, primarily posterior CG, was found patients. Degree atrophy related to severity injury. also had significantly reduced corpus callosum thalamic cross-sectional with associated increased ventricular volume, as well...
This study sought to replicate Herbert et al. (2003a) Herbert, M. R., Ziegler, D. A., Deutsch, C. K., O'Brien, L. M., Lange, N.Bakardjiev, A. 2003a. Dissociations of cerebral cortex, subcortical and white matter volumes in autistic boys.. Brain, 126(Pt 5): 1182–1192. [Crossref], [PubMed] , [Google Scholar], which found increased overall (WM) volume subjects with autism, even after controlling for head size differences. To avoid the possibility that greater WM autism is merely an epiphenomena...
Heightened auditory sensitivity and atypical processing are common in autism. Functional studies suggest abnormal neural response hemispheric activation to stimuli, yet the neurodevelopment underlying function autism is unknown. In this study, we model longitudinal volumetric growth of Heschl's gyrus gray matter white during childhood adolescence 40 individuals with 17 typically developing participants. Up three time points magnetic resonance imaging data, collected on average every 2.5...
Abstract Although there are several techniques to analyze diffusion‐weighted imaging, any technique must be sufficiently sensitive detect clinical abnormalities. This is especially critical in disorders like mild traumatic brain injury (mTBI), where pathology likely subtle. mTBI represents a major public health concern, for youth under 15 years of age. However, the developmental period from birth 18 also time tremendous changes. Therefore, it important establish degree age‐ and sex‐related...
Mild traumatic brain injury (TBI) is a global public health concern that affects millions of children annually. TBI tends to result in subtle and diffuse alterations tissue, which challenges accurate clinical detection prognostication. Diffusion tensor imaging (DTI) holds promise as diagnostic prognostic tool, but little research has examined DTI post-acute mild TBI. The current study compared white matter microstructure with versus those orthopedic (OI), whether metrics can predict chronic...
Objective To determine if history of mild traumatic brain injury (mTBI) is associated with advanced or accelerated aging among the United States (US) military Service Members and Veterans.Methods Eight hundred twenty-two participants (mean age = 40.4 years, 714 male/108 female) underwent MRI sessions at eight sites across US. Two one completed a follow-up scan between five months four years later. Predicted ages were calculated using T1-weighted MRIs then compared chronological to generate...
Mild traumatic brain injury (mTBI) disproportionately affects children and adolescents has been associated with poorer neurocognitive performance, but the variability in acute chronic symptoms presents challenges understanding biological mechanisms underlying symptom heterogeneity predicting these effects clinical settings. We hypothesized that genetic factors interact mTBI to determine vulnerability or resistance neurological dysfunction post-mTBI. leveraged baseline Adolescent Brain...
Objective: Investigate sex-related differences in mild traumatic brain injury (mTBI) risks due to sports among children aged 9 10 years and examine whether the benefits of participation, specifically behavioral, neurocognitive, psychiatric health, differ between boys girls. Setting: The Adolescent Brain Cognitive Development study involves 21 sites across United States. data were collected through comprehensive evaluations including neuroimaging, cognitive tests, mental health evaluations,...
This study examined the associations among brain volumes, theory of mind (ToM), peer relationships, and psychosocial adjustment in children with traumatic injury (TBI). Participants included 8- to 13-year-old children, 82 TBI 61 orthopedic injuries (OIs). Children completed three measures ToM. Classmates provided ratings participants’ acceptance, friendships. Parents rated children’s adjustment. MRI was used determine volumes. Brain volumes were associated ToM, which turn...
Background: White matter hyperintensities (WMHs) are foci of abnormal signal intensity in white regions seen with magnetic resonance imaging (MRI). WMHs associated normal ageing and have shown prognostic value neurological conditions such as traumatic brain injury (TBI). The impracticality manually quantifying these lesions limits their clinical utility motivates the utilization machine learning techniques for automated segmentation workflows.Methods: This study develops a concatenated...