A5090431009- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Graphene and Nanomaterials Applications
- Acupuncture Treatment Research Studies
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Visual perception and processing mechanisms
- Lipid Membrane Structure and Behavior
- Phagocytosis and Immune Regulation
- Neural and Behavioral Psychology Studies
- Ocular and Laser Science Research
- Immune cells in cancer
- Myofascial pain diagnosis and treatment
- Adenosine and Purinergic Signaling
- Advanced biosensing and bioanalysis techniques
- Virus-based gene therapy research
- MicroRNA in disease regulation
- Prenatal Screening and Diagnostics
- Complementary and Alternative Medicine Studies
- Nanoparticles: synthesis and applications
- Surfactants and Colloidal Systems
- HER2/EGFR in Cancer Research
- Supramolecular Self-Assembly in Materials
- Monoclonal and Polyclonal Antibodies Research
University of Montana
2022-2025
University of Arizona
2020-2025
Qujiang People's Hospital
2025
Guangzhou Medical University
2023-2024
University of Arizona Cancer Center
2020-2023
Arizona Science Center
2023
University of Southern California
2004-2022
Georgetown University
2020
University of California, Los Angeles
2012-2019
California NanoSystems Institute
2017-2019
While chemotherapy delivery by nanocarriers has modestly improved the survival prospects of pancreatic ductal adenocarcinoma (PDAC), additional engagement immune response could be game changing. We demonstrate a nano-enabled approach for accomplishing robust anti-PDAC immunity in syngeneic mice through induction immunogenic cell death (ICD) as well interfering immunosuppressive indoleamine 2,3-dioxygenase (IDO) pathway. This is accomplished conjugating IDO inhibitor, indoximod (IND), to...
Immunotherapy provides the best approach to reduce high mortality of metastatic breast cancer (BC). We demonstrate a chemo-immunotherapy approach, which utilizes liposomal carrier simultaneously trigger immunogenic cell death (ICD) as well interfere in regionally overexpressed immunosuppressive effect indoleamine 2,3-dioxygenase (IDO-1) at BC tumor site. The liposome was constructed by self-assembly phospholipid-conjugated prodrug, indoximod (IND), inhibits IDO-1 pathway, followed remote...
Abstract Cholesterol (Chol) fortifies packing and reduces fluidity permeability of the lipid bilayer in vesicles (liposomes)-mediated drug delivery. However, under physiological environment, Chol is rapidly extracted from by biomembranes, which jeopardizes membrane stability results premature leakage for delivered payloads, yielding suboptimal clinic efficacy. Herein, we report a Chol-modified sphingomyelin (SM) via covalently conjugating to SM (SM-Chol), retains condensing ability Chol....
Irinotecan is a key chemotherapeutic agent for the treatment of colorectal (CRC) and pancreatic (PDAC) cancer. Because high incidence bone marrow gastrointestinal (GI) toxicity, Onivyde (a liposome) was introduced to provide encapsulated irinotecan (Ir) delivery in PDAC patients. While there an ongoing clinical trial (NCT02551991) investigate use as first-line option replace FOLFIRINOX, liposomal formulation currently prescribed second-line (in combination with 5-fluorouracil leucovorin)...
Doxorubicin (DOX) is one of the most commonly used antineoplastic agents, but its clinical application oftentimes coupled with severe side effects. Selective delivery DOX to tumors via nanosized drug carrier represents an attractive approach this problem. Previously, we developed a dual functional nanomicellar carrier, PEG5K-embelin2 (PEG5K-EB2), which was able deliver paclitaxel (PTX) selectively and achieve enhanced therapeutic effect. In present study, examined utility PEG5K-EB2 tumors....
Nanoparticles (NPs) can be used to accomplish antigen-specific immune tolerance in allergic and autoimmune disease. The available options for custom-designing tolerogenic NPs include the use of nanocarriers that introduce antigens into natural environments, such as liver, where antigen presentation promotes self- or foreign antigens. Here, we demonstrate engineering a biodegradable polymeric poly(lactic-co-glycolic acid) (PLGA) nanocarrier selective delivery murine allergen, ovalbumin (OVA),...
Although the selective and effective clearance of senescent cancer cells can improve treatment, their development is confronted by many challenges. As part efforts designed to overcome these problems, prodrugs, whose design based on senescence-associated β-galactosidase (SA-β-gal), have been developed selectively eliminate cells. However, chemotherapies relying targeted molecular inhibitors as senolytic drugs induce drug resistance. In current investigation, we devised a new strategy for...
Abstract Nanocellulose is increasingly considered for applications; however, the fibrillar nature, crystalline phase, and surface reactivity of these high aspect ratio nanomaterials need to be safe biomedical use. Here a comprehensive analysis impact cellulose nanofibrils (CNF) nanocrystals (CNC) performed using materials provided by Nanomaterial Health Implications Research Consortium National Institute Environmental Sciences. An intermediary length also derived acid hydrolysis. While all...
Embelin, identified primarily from the Embelia ribes plant, has been shown to be a natural small molecule inhibitor of X-linked apoptosis protein (XIAP). It is also potent NF-κB activation, which makes it potentially effective suppressor tumor cell survival, proliferation, invasion, angiogenesis, and inflammation. However, embelin itself insoluble in water, unsuitable for vivo applications. In this work, we developed novel micelle system through conjugating hydrophilic polymer, poly(ethylene...
Various PEG-Vitamin E conjugates including d-α-tocopheryl poly(ethylene glycol) succinate 1000 (TPGS) have been extensively studied as a nonionic surfactant in various drug delivery systems. However, limited information is available about the structure-activity relationship of micellar formulation for paclitaxel (PTX). In this study, four were developed that vary molecular weight PEG (PEG2K vs PEG5K) and molar ratio PEG/Vitamin (1/1 1/2) conjugates. These systematically characterized with...
iRGD-mediated nanoparticle transcytosis in a solid tumor.
Epacadostat (EPA), the most advanced IDO1 inhibitor, in combination with PD-1 checkpoint has failed a recent Phase III clinical trial for treating metastatic melanoma. Here we report an EPA nanovesicle therapeutic platform (Epacasome) based on chemically attaching to sphingomyelin via oxime-ester bond highly responsive hydrolase cleavage. Via clathrin-mediated endocytosis, Epacasome displays higher cellular uptake and enhances inhibition T cell proliferation compared free EPA. shows improved...