A5091205267- Nanoparticles: synthesis and applications
- Graphene and Nanomaterials Applications
- Air Quality and Health Impacts
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Chemical Synthesis and Analysis
- RNA Interference and Gene Delivery
- Advanced Wireless Communication Techniques
- Advanced biosensing and bioanalysis techniques
- Error Correcting Code Techniques
- Topic Modeling
- Heavy Metal Exposure and Toxicity
- Crystal structures of chemical compounds
- Natural Language Processing Techniques
- Electrochemical Analysis and Applications
- Immunotherapy and Immune Responses
- Synthesis and biological activity
- Advanced Nanomaterials in Catalysis
- Inflammasome and immune disorders
- Microplastics and Plastic Pollution
- Computational Drug Discovery Methods
- Synthetic Organic Chemistry Methods
- Catalytic C–H Functionalization Methods
- MXene and MAX Phase Materials
- Heme Oxygenase-1 and Carbon Monoxide
Chinese Academy of Sciences
2008-2025
University of Michigan
2025
Dalian Institute of Chemical Physics
2018-2025
Hebei University of Science and Technology
2011-2024
Huazhong University of Science and Technology
2015-2024
University of California, Los Angeles
2015-2024
California NanoSystems Institute
2015-2024
Union Hospital
2010-2024
Qingdao University of Science and Technology
2017-2024
Peking University
2001-2024
Nanomaterials (NM) exhibit novel physicochemical properties that determine their interaction with biological substrates and processes. Three metal oxide nanoparticles are currently being produced in high tonnage, TiO(2), ZnO, CeO(2), were synthesized by flame spray pyrolysis process compared a mechanistic study to elucidate the characteristics cellular uptake, subcellular localization, toxic effects based on test paradigm was originally developed for oxidative stress cytotoxicity RAW 264.7...
Nanomaterial properties differ from those bulk materials of the same composition, allowing them to execute novel activities. A possible downside these capabilities is harmful interactions with biological systems, potential generate toxicity. An approach assess safety nanomaterials urgently required. We compared cellular effects ambient ultrafine particles manufactured titanium dioxide (TiO2), carbon black, fullerol, and polystyrene (PS) nanoparticles (NPs). The study was conducted in a...
Overexpression of drug efflux transporters such as P-glycoprotein (Pgp) protein is one the major mechanisms for multiple resistance (MDR) in cancer cells. A new approach to overcome MDR use a co-delivery strategy that utilizes siRNA silence expression transporter together with an appropriate anticancer resistant In this paper, we report mesoporous silica nanoparticles (MSNP) can be functionalized effectively deliver chemotherapeutic agent doxorubicin (Dox) well Pgp drug-resistant cell line...
Surface-functionalized mesoporous silica nanoparticles (MSNP) can be used as an efficient and safe carrier for bioactive molecules. In order to make the MSNP a more delivery system, we modified surface of particles by functional group that enhances cellular uptake allows nucleic acid in addition traditional drug delivery. Noncovalent attachment polyethyleneimine (PEI) polymers not only increases but also generates cationic which DNA siRNA constructs could attached. While intracellular these...
We demonstrate for 24 metal oxide (MOx) nanoparticles that it is possible to use conduction band energy levels delineate their toxicological potential at cellular and whole animal levels. Among the materials, overlap of (Ec) with redox (−4.12 −4.84 eV) was strongly correlated ability Co3O4, Cr2O3, Ni2O3, Mn2O3, CoO induce oxygen radicals, oxidative stress, inflammation. This outcome premised on permissible electron transfers from biological couples maintain equilibrium semiconductor...
The exponential increase in the number of new nanomaterials that are being produced increases likelihood adverse biological effects humans and environment. In this study we compared cationic nanoparticles five different cell lines represent portal-of-entry or systemic cellular targets for engineered nanoparticles. Although 60 nm NH(2)-labeled polystyrene (PS) nanospheres were highly toxic macrophage (RAW 264.7) epithelial (BEAS-2B) cells, human microvascular endothelial (HMEC), hepatoma...
Mesoporous silica nanoparticles (MSNP) have proven to be an extremely effective solid support for controlled drug delivery on account of the fact that their surfaces can easily functionalized in order control nanopore openings. We described recently a series mechanized nanoparticles, which, under abiotic conditions, are capable delivering cargo molecules employing nanovalves. The key question these systems has now become whether they adapted biological use through nanovalve opening cells....
We used a multifunctional mesoporous silica nanoparticle (MSNP) carrier to overcome doxorubicin (Dox) resistance in multidrug resistant (MDR) human breast cancer xenograft by codelivering Dox and siRNA that targets the P-glycoprotein (Pgp) drug exporter. The Pgp selection from among series of was achieved performing high throughput screening MDR cell line, MCF-7/MDR. Following establishment MCF-7/MDR model nude mice, we demonstrated 50 nm MSNP, functionalized polyethyleneimine–polyethylene...
The establishment of verifiably safe nanotechnology requires the development assessment tools to identify hazardous nanomaterial properties that could be modified improve safety. While there is a lot debate what constitutes appropriate safety screening methods, one approach use cellular injury pathways collect knowledge about material lead harm humans and environment. We demonstrate multiparameter cytotoxicity assay evaluates toxic oxidative stress compare effects titanium dioxide (TiO2),...
A key challenge for improving the efficacy of passive drug delivery to tumor sites by a nanocarrier is limit reticuloendothelial system uptake and maximize enhanced permeability retention effect. We demonstrate that size reduction surface functionalization mesoporous silica nanoparticles (MSNP) with polyethyleneimine–polyethylene glycol copolymer reduces particle opsonization while enhancing monodispersed, 50 nm doxorubicin-laden MSNP human squamous carcinoma xenograft in nude mice after...
Particulate pollutants cause adverse health effects through the generation of oxidative stress. A key question is whether these are mediated by particles or their chemical compounds. In this article we show that aliphatic, aromatic, and polar organic compounds, fractionated from diesel exhaust (DEPs), exert differential toxic in RAW 264.7 cells. Cellular analyses showed quinone-enriched fraction was more potent than polycyclic aromatic hydrocarbon (PAH)–enriched O2•− generation, decrease...
We have developed structure/toxicity relationships for amorphous silica nanoparticles (NPs) synthesized through low-temperature colloidal (e.g., Stöber silica) or high-temperature pyrolysis fumed routes. Through combined spectroscopic and physical analyses, we determined the state of aggregation, hydroxyl concentration, relative proportion strained unstrained siloxane rings, potential to generate radicals NPs with comparable primary particle sizes (16 nm in diameter). On basis erythrocyte...
Graphene oxide (GO) is increasingly used in biomedical applications because it possesses not only the unique properties of graphene including large surface area and flexibility but also hydrophilicity dispersibility aqueous solutions. However, there are conflicting results on its biocompatibility biosafety partially due to variations physicochemical GO, role these lateral size biological or toxicological effects GO still unclear. In this study, we focused by preparing a panel samples with...
UV-light-induced electron-hole (e(-)/h(+)) pair generation with free radical production in TiO(2)-based nanoparticles is a major conceptual paradigm for biological injury. However, to date, this hypothesis has been difficult experimentally verify due the high energy of UV light that intrinsically highly toxic systems. Here, versatile flame spray pyrolysis (FSP) synthetic process exploited synthesize library iron-doped (0-10 wt%) TiO(2) nanoparticles. These particles have tested...
The first cross-coupling of acylated phenol derivatives has been achieved. In the presence an air-stable Ni(II) complex, readily accessible aryl pivalates participate in Suzuki-Miyaura coupling with arylboronic acids. process is tolerant considerable variation each components. addition, a one-pot acylation/cross-coupling sequence developed. potential to utilize pivalate as directing group also demonstrated, along ability sequentially cross-couple bromide followed by pivalate, using palladium...
We have recently shown that the dissolution of ZnO nanoparticles and Zn2+ shedding leads to a series sublethal lethal toxicological responses at cellular level can be alleviated by iron doping. Iron doping changes particle matrix slows rate dissolution. To determine whether also lesser toxic effects in vivo, toxicity studies were performed rodent zebrafish models. First, we synthesized fresh batch doped with 1−10 wt % Fe. These particles extensively characterized confirm their status,...
We investigated and compared nanosize Ag spheres, plates, wires in a fish gill epithelial cell line (RT-W1) zebrafish embryos to understand the mechanism of toxicity an engineered nanomaterial raising considerable environmental concern. While most nanoparticles induced N-acetyl cysteine sensitive oxidative stress effects RT-W1, nanoplates were considerably more toxic than other particle shapes. Interestingly, while ion shedding bioavailability failed comprehensively explain high nanoplates,...