A5100453243- Asthma and respiratory diseases
- Inhalation and Respiratory Drug Delivery
- Graphene and Nanomaterials Applications
- Nanoplatforms for cancer theranostics
- Immunotherapy and Immune Responses
- Respiratory and Cough-Related Research
- Allergic Rhinitis and Sensitization
- Immune Cell Function and Interaction
- Food Allergy and Anaphylaxis Research
- RNA Interference and Gene Delivery
- Advanced Cellulose Research Studies
- Lung Cancer Research Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Polysaccharides and Plant Cell Walls
- Nanoparticle-Based Drug Delivery
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- SARS-CoV-2 and COVID-19 Research
- Phagocytosis and Immune Regulation
- Fungal Plant Pathogen Control
- Dental Trauma and Treatments
- Molecular Communication and Nanonetworks
- Chronic Lymphocytic Leukemia Research
- Curcumin's Biomedical Applications
- Phonocardiography and Auscultation Techniques
Beihang University
2024-2025
Hunan University
2024
Qingdao University
2024
Affiliated Hospital of Qingdao University
2024
Harbin Medical University
2023
Second Affiliated Hospital of Harbin Medical University
2023
Ministry of Education of the People's Republic of China
2023
Johns Hopkins Medicine
2022
Johns Hopkins University
2022
East China University of Science and Technology
2022
We developed a custom-designed liposome carrier for codelivery of potent immunogenic cell death (ICD) stimulus plus an inhibitor the indoleamine 2,3-dioxygenase (IDO-1) pathway to establish chemo-immunotherapy approach solid tumors in syngeneic mice. The was constructed by remote import anthraquinone chemotherapeutic agent, mitoxantrone (MTO), into liposomes, which were further endowed with cholesterol-conjugated indoximod (IND) prodrug lipid bilayer. For proof-of-principle testing, we used...
Nanoparticles (NPs) can be used to accomplish antigen-specific immune tolerance in allergic and autoimmune disease. The available options for custom-designing tolerogenic NPs include the use of nanocarriers that introduce antigens into natural environments, such as liver, where antigen presentation promotes self- or foreign antigens. Here, we demonstrate engineering a biodegradable polymeric poly(lactic-co-glycolic acid) (PLGA) nanocarrier selective delivery murine allergen, ovalbumin (OVA),...
Abstract There is an urgent need to develop new life‐prolonging therapy for pancreatic ductal adenocarcinoma (PDAC). It demonstrated that improved irinotecan delivery by a lipid bilayer coated mesoporous silica nanoparticle, also known as silicasome, can improve PDAC survival through chemo‐immunotherapy response in orthotopic Kras‐dependent cancer model. This discovery premised on the weak‐basic properties of irinotecan, which neutralizes acidic lysosomal pH cells. effect triggers linked...
Abstract Nanocellulose is increasingly considered for applications; however, the fibrillar nature, crystalline phase, and surface reactivity of these high aspect ratio nanomaterials need to be safe biomedical use. Here a comprehensive analysis impact cellulose nanofibrils (CNF) nanocrystals (CNC) performed using materials provided by Nanomaterial Health Implications Research Consortium National Institute Environmental Sciences. An intermediary length also derived acid hydrolysis. While all...
Abstract The mononuclear phagocyte system in the liver is a frequent target for nanoparticles (NPs). A toxicological profiling of metal‐based NPs performed Kupffer cell (KC) and hepatocyte lines. Sixteen are provided by Nanomaterial Health Implications Research Consortium National Institute Environmental Sciences to study effects KUP5 Hepa 1–6 cells. Five (Ag, CuO, ZnO, SiO 2 , V O 5 ) exhibit cytotoxicity both types, while induce IL‐1β production KC. Ag, ZnO induced caspase 3 generated...
The targeting of natural tolerogenic liver sinusoidal endothelial cells (LSEC) by nanoparticles (NPs), decorated with a stabilin receptor ligand, is capable generating regulatory T-cells (Tregs), which can suppress antigen-specific immune responses, including to ovalbumin (OVA), possible food allergen. In this regard, we have previously demonstrated that OVA-encapsulating poly(lactic-co-glycolic acid) (PLGA) eliminate allergic airway inflammation in OVA-sensitized mice, prophylactically and...
Nanocellulose including cellulose nanocrystal (CNC) and nanofiber (CNF) has attracted much attention due to its exceptional mechanical, chemical, rheological properties. Although considered biocompatible, recent reports have demonstrated nanocellulose can be hazardous, serving as drug carriers that accumulate in the liver. However, effects on liver cells, Kupffer cells (KCs) hepatocytes are unclear. Here, toxicity of with different lengths is compared, shorter CNCs (CNC-1, CNC-2, CNC-3)...
Autoimmune diseases, allergies, transplant rejections, generation of antidrug antibodies, and chronic inflammatory diseases have impacted a large group people across the globe. Conventional treatments therapies often use systemic or broad immunosuppression with serious efficacy safety issues. Tolerogenic vaccines represent concept that has been extended from their traditional immune-modulating function to induction antigen-specific tolerance through regulatory T cells. Without impairing...
Poorly designed devices can cause flow maldistribution, leading to subpar performance during macromolecule separation. Analyzing the fluid in intricate membrane channel structures is challenging. In this study, computational dynamics (CFD) was employed investigate effects of tortuosity, size, and connectivity on distribution chromatography performance. Sodium chloride (NaCl) bovine serum albumin (BSA) were used as tracers. The results showed that peaks from NaCl BSA sharper tortuosity size...
Abstract BACKGROUND Owing to the advantages of high‐efficiency, environmental protection and safety, nanoemulsions have become a highly popular water‐insoluble pesticide delivery system in recent years. RESULTS In this study, abamectin‐loaded nanoemulsion with remarkable physical stability application performance was obtained by selecting type concentration surfactant emulsification method. The optimal formula 2% abamectin 5% castor oil polyoxyethylene (EL‐40) dissolved 7.5% hydrocarbon...
Magnetic resonance imaging (MRI) combined with ultrasmall superparamagnetic iron oxide (USPIO) is effective for the detection of atherosclerotic (AS) plaque, and paclitaxel treatment AS. C11 a polypeptide high affinity specificity collagen IV. It abundantly expressed in outer layer AS plaque. This study aimed to develop USPIO + paclitaxel-loaded polymer-lipid hybrid theranostic nanoparticles conjugated (UP-NP-C11) simultaneous UP-NP-C11 was developed by nanoprecipitation method, theranostics...
Stem cell therapy shows great potential in the treatment of neurodegenerative diseases, which efficient neural differentiation stem cells is still challenging.
2D boron nitride (BN) and molybdenum disulfide (MoS2 ) materials are increasingly being used for applications due to novel chemical, electronic, optical properties. Although generally considered biocompatible, recent data have shown that BN MoS2 could potentially be hazardous under some biological conditions, example, during, biodistribution of drug carriers or imaging agents the liver. However, effects these on liver cells such as Kupffer (KCs), sinusoidal endothelial cells, hepatocytes,...
For most frequent respiratory viruses, there is an urgent need for a universal influenza vaccine to provide cross-protection against intra- and heterosubtypes. We previously developed Escherichia coli fusion protein expressed extracellular domain of matrix 2 (M2e) nucleoprotein, named NM2e, then combined it with aluminum adjuvant, forming vaccine. Although NM2e has demonstrated protective effect the virus in mice some extent, further improvement still needed induction immune responses...
In recent years, multicellular spheroid (MCS) culture has been extensively studied both in fundamental research and application fields since it inherits much more characteristics from vivo solid tumor than conventional two-dimensional (2D) cell culture. However, anticell adhesive MCS systems such as hanging drop allow certain lines only to form loose, irregular aggregates rather with physiological barriers pathophysiological gradients, which failed mimic these aspects. To address this issue,...
Chloroquine (CQ) and hydroxychloroquine (HCQ) have been challenged in treating COVID-19 patients still under debate due to the uncertainty regarding effectiveness safety, there is lack of systematic study on toxicity these two drugs. To further uncover profile CQ HCQ different tissues, we evaluated cytotoxicity them eight cell lines adopted physiologically based pharmacokinetic models predict tissue risk, respectively. Retina, myocardium, lung, liver, kidney, vascular endothelium, intestinal...