A5074876487- Bone health and osteoporosis research
- Bone Metabolism and Diseases
- Bone health and treatments
- Orthopaedic implants and arthroplasty
- Osteoarthritis Treatment and Mechanisms
- Lipoproteins and Cardiovascular Health
- Cancer, Lipids, and Metabolism
- Bone and Joint Diseases
- Vitamin D Research Studies
- Bone Tissue Engineering Materials
- Bone fractures and treatments
- COVID-19 Clinical Research Studies
- Hip and Femur Fractures
- Inflammatory mediators and NSAID effects
- Spine and Intervertebral Disc Pathology
- SARS-CoV-2 and COVID-19 Research
- Titanium Alloys Microstructure and Properties
- Drug-Induced Ocular Toxicity
- Orthopedic Infections and Treatments
- RNA modifications and cancer
- Biomarkers in Disease Mechanisms
- Vitamin K Research Studies
- Mesenchymal stem cell research
- Nerve injury and regeneration
- Gut microbiota and health
Peking University
2016-2025
Peking University Third Hospital
2016-2025
Handan College
2024
Dalian Medical University
2017-2024
First Affiliated Hospital of Dalian Medical University
2017-2024
Beijing Municipal Education Commission
2022
Ministry of Education of the People's Republic of China
2022
Spinal Research
2019-2021
Beijing Haidian Hospital
2017-2020
State Council of the People's Republic of China
2019-2020
Abstract Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) first broke out in 2019 and subsequently spread worldwide. Chloroquine has been sporadically used treating SARS-CoV-2 infection. Hydroxychloroquine shares the same mechanism of action as chloroquine, but its more tolerable safety profile makes it preferred drug to treat malaria autoimmune conditions. We propose that immunomodulatory effect hydroxychloroquine also may be useful controlling cytokine storm...
Background Hip fracture is a public health concern because of its considerable morbidity, excess mortality, great risk disability, and high societal healthcare costs. China has the largest population older people in world experiencing rapid aging facing challenges from an increasing number hip fractures. However, few studies reported epidemiology, especially at national level. We aimed to evaluate trends incidence associated costs for hospitalization China. Methods findings conducted...
3D printed porous titanium (Ti) holds enormous potential for load-bearing orthopedic applications. Although the printing technique has good control over macro-sturctures of Ti, surface properties that affect tissue response are beyond its control, adding need tailored treatment to improve osseointegration capacity. Here, one step microarc oxidation (MAO) process was applied a Ti6Al4V (Ti64) scaffold endow with homogeneous layer microporous TiO2 and significant amounts amorphous...
Three-dimensional porous titanium alloys printed via electron beam melting have low stiffness similar to that of cortical bone and are promising scaffolds for orthopedic applications. However, the bio-inert nature alloy is poorly compatible with ingrowth. We previously observed simvastatin/poloxamer 407 thermosensitive hydrogel induces endogenous angiogenic/osteogenic growth factors promotes angiogenesis osteogenesis, but mechanical properties this poor. The purpose study was construct...
Implant-associated infections (IAIs) caused by biofilm formation are the most devastating complications of orthopedic surgery. Statins have been commonly and safely used drugs for hypercholesterolemia many years. Here, we report that simvastatin-hydroxyapatite-coated titanium alloy prevents biofilm-associated infections. The antibacterial properties simvastatin against Staphylococcus aureus epidermidis biofilms in vitro was confirmed crystal violet staining live-dead bacterial staining. We...
Postmenopausal osteoporosis is a common bone metabolic disease, and gut microbiota (GM) imbalance plays an important role in the development of disease. Here, we show that ovariectomized mice had high levels lipopolysaccharide serum dysbiosis through increases luminal Firmicutes:Bacteroidetes ratio. We depleted GM antibiotic treatment observed improvements mass, microstructure, strength mice. Conversely, transplantation adapted to ovariectomy induced loss. However, depletion reversed...
Abstract The autonomic nervous system plays a crucial role in regulating bone metabolism, with sympathetic activation stimulating resorption and inhibiting formation. We found that fractures lead to increased tone, enhanced osteoclast resorption, decreased osteoblast formation, thus hastened systemic loss ovariectomized (OVX) mice. However, the combined administration of parathyroid hormone (PTH) β-receptor blocker propranolol dramatically promoted formation osteoporotic fracture healing OVX...
Abstract Gut microbiota dysbiosis has been studied under the pathological conditions of osteoarthritis (OA). However, effect antibiotic-induced gut flora on OA remains incompletely understood at present. Herein, we used a mouse (8 weeks) model destabilization medial meniscus (DMM) and microbiome induced by antibiotic treatment with ampicillin neomycin for 8 weeks. The results show that intestinal reduced serum level lipopolysaccharide (LPS) inflammatory response, such as suppression levels...
Homocysteine, inversely related to folate and vitamin B12, is an independent risk factor for several age-related disorders. However, little known about the association of homocysteine vitamins with osteoarthritis (OA). This study aimed elucidate potential causal effects homocysteine, folate, B12 on site- gender-specific OA by applying two-sample Mendelian randomization (MR) approach. Genetically predicted showed adverse overall (95% confidence interval (CI): 1.044-1.155), knee CI:...
Postoperative anatomical reconstruction and prevention of local recurrence after tumor resection are two vital clinical challenges in osteosarcoma treatment. A three-dimensional (3D)-printed porous Ti6Al4V scaffold (3DTi) is an ideal material for reconstructing critical bone defects with numerous advantages over traditional implants, including a lower elasticity modulus, stronger bone-implant interlock, larger drug-loading space. Simvastatin multitarget drug anti-tumor osteogenic potential;...
Abstract Treating peripheral nerve defects represents a clinical challenge, and conduits lacking an internal scaffold lead to limited large gap regeneration. Here, we bridged 10‐mm sciatic in rats with chitosan conduit filled 0, 0.5, or 1.0 mg of simvastatin Pluronic F‐127 hydrogel. We assessed subsequent regeneration using the functional index (SFI), electrophysiological assessments, Fluoro‐Gold (FG) retrograde tracing, gastrocnemius muscle mass measurements, histological...
Chloroquine (CQ) phosphate has been suggested to be clinically effective in the treatment of coronavirus disease 2019 (COVID-19). To develop a physiologically-based pharmacokinetic (PBPK) model for predicting tissue distribution CQ and apply it optimize dosage regimens, PBPK model, with parameterization drug extrapolated from animal data, was developed predict human CQ. The physiological characteristics time-dependent accumulation mimicked through an active transport mechanism. Several...
Sustainable release of vancomycin from micro-arc oxidised 3D-printed porous Ti6A14V for treating MRSA bone infection and enhancing osteogenesis.
Background: Osteoporotic vertebral fractures cause pain and disability, which result in heavy socioeconomic burden. However, the incidence cost of China are unknown. We aimed to assess clinically recognized among people aged 50 years older from 2013 2017. Materials Methods: This population-based cohort study was conducted by using Urban Employee Basic Medical Insurance (UEBMI) Resident (URBMI) data 2017, covered more than 95% Chinese population urban areas. Vertebral were identified primary...
This study aims to determine the etiology, clinical characteristics, and treatment of atypical femur fractures (AFFs). Clinical data from patients with an AFF who were treated in our hospital January 2017 June 2021 retrospectively reviewed. The analyzed summarized. Twenty-one (17 females 4 males; average age, 66.59 ± 13.52 years; age range, 32–85 years) AFFs (27 femurs [6 bilateral femurs]) included current study. Based on relative risk analysis it was determined that long-term use...
Aims: To evaluate the efficacy of stromal vascular fraction (SVF) in treating osteoarthritis (OA). Background: OA is a common degenerative disease, most important manifestation which cartilage destruction and inflammation. The SVF mixed group multiple cells extracted from adipose tissue with certain ability to promote repair. However, biological safety human derived have not been confirmed. Methods: Seventy‐six nude rats were used this experiment. rat model was constructed anterior cruciate...