A5101694817- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Cervical and Thoracic Myelopathy
- Orthopaedic implants and arthroplasty
- Bone Tissue Engineering Materials
- Medical Imaging and Analysis
- Orthopedic Infections and Treatments
- Total Knee Arthroplasty Outcomes
- Pelvic and Acetabular Injuries
- Titanium Alloys Microstructure and Properties
- Scoliosis diagnosis and treatment
- Hip disorders and treatments
- Bone Tumor Diagnosis and Treatments
- Bone fractures and treatments
- Management of metastatic bone disease
- Spinal Hematomas and Complications
- Spinal Cord Injury Research
- Head and Neck Surgical Oncology
- Osteoarthritis Treatment and Mechanisms
- Heterotopic Ossification and Related Conditions
- Dental Radiography and Imaging
- Nerve injury and regeneration
- Infectious Diseases and Tuberculosis
- Lipoproteins and Cardiovascular Health
- Polymer Surface Interaction Studies
Peking University
2016-2025
Peking University Third Hospital
2016-2025
Ministry of Education of the People's Republic of China
2020-2022
Creative Commons
2018-2020
Beijing Haidian Hospital
2020
State Council of the People's Republic of China
2019
Southern Medical University
2018
State Key Laboratory of Oral Diseases
2012
Sichuan University
2012
Lac Courte Oreilles Ojibwa Community College
2007
3D printed porous titanium (Ti) holds enormous potential for load-bearing orthopedic applications. Although the printing technique has good control over macro-sturctures of Ti, surface properties that affect tissue response are beyond its control, adding need tailored treatment to improve osseointegration capacity. Here, one step microarc oxidation (MAO) process was applied a Ti6Al4V (Ti64) scaffold endow with homogeneous layer microporous TiO2 and significant amounts amorphous...
Restoring large-scale bone defects, where osteogenesis is slow while infections lurk, with biomaterials represents a formidable challenge in orthopedic clinics. Here, we propose scaffold-based multipurpose anti-infection and repairing strategy to meet such restorative needs. To do this, personalized multifunctional titanium meshes were produced through an advanced additive manufacturing process dual "TiO2–poly(dopamine)/Ag (nano)" post modifications, yielding macroporous constructs...
Bone defect repairs are based on bone graft fusion or replacement. Current large treatments inadequate and lack of reliable technology. Therefore, we aimed to investigate a simple technique using three-dimensional (3D)-printed individualized porous implants without any grafts, osteoinductive agents, surface biofunctionalization treat defects, systematically study its long-term therapeutic effects osseointegration characteristics. Twenty-six patients with defects caused by tumor, infection,...
Surgical resection and perioperative adjuvant chemotherapy-based therapies have improved the prognosis of patients with osteosarcoma; however, intraoperative bone defects, local tumour recurrence, chemotherapy-induced adverse effects still affect quality life patients. Emerging 3D-printed titanium alloy (Ti6Al4V) implants advantages over traditional in repair, including lower elastic modulus, stiffness, better conduction, more in-growth, stronger mechanical interlocking, lager drug-loading...
Retrospective review.To perform a single-institution analysis of incidence, treatment, and clinical outcome in patients with thoracic ossification the ligamentum flavum (OLF) who experienced dural tears cerebrospinal fluid (CSF) leakage.There is paucity reports focusing on CSF leakage after OLF surgery. Because adhesion are common features OLF, incidence high represents significant challenge.A total 266 were admitted to our hospital from 1995 2011. Each patient's medical records reviewed...
Titanium‐based implants possessing adequately low elasticity modulus and customdesigned structures are urgently demanded in recent years for orthopedic applications. Electron beam melting (EBM) provides an opportunity to fabricated porous titanium scaffolds that meet the as‐mentioned requirements, it further allows improved bone regeneration increased contact area at implant–tissue interface. As a novel additive manufacturing (AM) technique, EBM could conveniently produce with tunable...
Three-dimensional (3D)-printed porous Ti6Al4V implants play an important role in the reconstruction of bone defects. However, its osseointegration capacity needs to be further improved, and related methods are inadequate, especially lacking customized surface treatment technology. Consequently, we aimed design omnidirectional radiator based on ultraviolet (UV) photofunctionalization for 3D-printed implants, studied promotion effects vitro vivo, while elucidating mechanisms. Following UV...
Percutaneous vertebroplasty (PVP) typically involves conventional lower-viscosity cement injection via bipedicular approach. Limited evidence is available comparing the clinical outcomes and complications in treating osteoporotic vertebral compression fractures (OVCFs) with PVP using high-viscosity through unipedicular or approach.Fifty patients OVCFs were randomly allocated into two groups adopting PVP. The efficacy of was assessed by operation time, X-ray exposure incidence complications,...
Advances in meticulous dural closure technique remain a great challenge for watertight the aged society, because cerebrospinal fluid (CSF) leakage after spinal surgery is often accompanied with disgusting wound infection, meningitis and pseudomeningocele. Here, tetra-poly (ethylene glycol) (PEG)-based hydrogel sealant developed collective advantages of facile operation, high safety, quick set time, easy injectability, favorable mechanical strength powerful tissue adhesion effective...
Osteoarthritis (OA) is a prevalent debilitating whole-joint disorder. Currently, growing number of proteomic studies have been performed to evaluate molecular biomarkers in several tissues from OA patients; however, little known about the protein profiles subchondral bone OA. In this study, analysis was on patients with identify differentially expressed proteins (DEPs). Bioinformatics tools were used further investigate these DEPs. Thereafter, DEPs validated samples OA, as well bilateral...
Retrospective study. To investigate the impact of preoperative C2 slope (C2S) on change in sagittal vertical axis (SVA) and postoperative cervical imbalance (CSI) after laminoplasty (LP). Consecutive patients who underwent LP between January 2015 2022 with a minimum 12-month follow-up were reviewed. The clinical variables radiographic measurements assessed. Patients divided into improvement (ΔcSVA ≤ -10 mm), stable (-10 mm ΔcSVA <10 CSI groups (ΔcSVA≥10 mm). Correlation analysis was...
Retrospective study.The aims of this study were to evaluate the radiographic and clinical outcomes Bryan cervical disc arthroplasty at 10-year follow-up.Cervical is a new technique for treating degenerative disease. Previous reports have shown that with gained good 4- 6-year follow-up.Clinical dynamic x-ray examination evaluated baseline final follow-up.Thirty-three patients complete data included in study. The mean follow-up period was 120.5 months (116-130 months). Twenty-five underwent...
BACKGROUND:Vertebral hemangioma is usually a benign and asymptomatic tumor of blood vessels, but can be aggressive (symptomatic) with expansion, pain, spinal cord compression. The aim this study was to review the effects radiotherapy, surgery, other treatment approaches in patients vertebral hemangioma. MATERIAL AND METHODS:Retrospective clinical included 20 who underwent radiotherapy as their first-line for mild or slowly developing neurological deficit. External radiation divided into...
Three-dimensional (3D)-printed porous Ti6Al4V implants are commonly used for reconstructing bone defects in the treatment of orthopaedic diseases owing to their excellent osteoconduction. However, achieve improved therapeutic outcomes, osteoinduction these requires further improvement. The aim this study was investigate combined use recombinant human BMP-2 (rhBMP-2) with a 3D-printed artificial vertebral implant (3D-AVI) improve osteoinduction. Eight male Small Tail Han sheep underwent...
Abstract Background Aseptic cup loosening is still one of the main reasons leading to acetabular failures. 3D printing porous trabecular titanium metal may provide good initial stability and secondary fixation because its highly interconnected, structure. Few large sample studies have reported clinical outcomes electron beam melting (EBM) in Chinese population. Methods We retrospectively collected analyzed data a total 92 consecutive patients between January 2013 November 2017, with an...