A5100747376- Anesthesia and Neurotoxicity Research
- Intensive Care Unit Cognitive Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Anesthesia and Sedative Agents
- Lipoproteins and Cardiovascular Health
- Sleep and Wakefulness Research
- Neuroscience and Neuropharmacology Research
- Circadian rhythm and melatonin
- Bone Metabolism and Diseases
- Parkinson's Disease Mechanisms and Treatments
- Ultrasound and Hyperthermia Applications
- Alzheimer's disease research and treatments
- Cancer, Stress, Anesthesia, and Immune Response
- MicroRNA in disease regulation
- Spinal Cord Injury Research
- Advanced Glycation End Products research
- Bone health and osteoporosis research
- Neurological Disease Mechanisms and Treatments
- Infrared Thermography in Medicine
- Diet and metabolism studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Metabolomics and Mass Spectrometry Studies
- Sleep and related disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Orthopaedic implants and arthroplasty
Peking University Third Hospital
2016-2025
Peking University
2016-2025
Yanshan University
2023
Xi'an Jiaotong University
2022
Systemic inflammation often induces neuroinflammation and disrupts neural functions, ultimately causing cognitive impairment. Furthermore, neuronal is the key cause of many neurological conditions. It particularly important to develop effective neuroprotectants prevent control inflammatory brain diseases. Baicalin (BAI) has a wide variety potent neuroprotective enhancement properties in various models injury through antioxidation, anti-inflammation, anti-apoptosis, stimulating neurogenesis....
Postoperative delirium (POD) is a common postsurgical complication that seriously affects patients' prognosis and imposes heavy burden on families society. Type 2 diabetes mellitus (T2DM) major risk factor for POD. The susceptibility mechanisms of POD in T2DM individuals the role exercise preconditioning remain unclear. Adult rats with without were used to assess promotive effect postoperative delirium-like behavior. diabetic also subjected swimming program before surgery. potential...
Statins have been reported to promote bone formation. However, taken orally, their bioavailability is low the bones. Implant therapies require a local repair response, topical application of osteoinductive agents, or biomaterials that implant fixation.The present study evaluated effect single injection simvastatin on screw fixation in an ovariectomized rat model osteoporosis.Dual-energy X-ray absorptiometry, micro-computed tomography, histology, and biomechanical tests revealed 5 10 mg...
Stress-induced α-synuclein aggregation, especially the most toxic species (oligomers), may precede synaptic and cognitive dysfunction.Under pathological conditions, is degraded primarily through autophagic/lysosomal pathway.We assessed involvement of autophagy in aggregation impairment following general anesthesia surgical stress.Autophagy was found to be suppressed aged rat hippocampus after either 4-h propofol alone or 2-h during a laparotomy surgery.This inhibition accompanied by profound...
To investigate dysregulated molecules in preoperative cerebrospinal fluid (CSF) of elderly hip fracture patients with postoperative delirium (POD), order to identify potential pathological mechanisms and biomarkers for pre-stage POD.This nested case control study used untargeted metabolomic lipidomic analysis profile the CSF (n = 40) who developed POD undergone surgery 10) those did not 30). Thirty Non-POD were matched 10 by age (± 2 years) Mini Mental State Examination score points). was...
Elderly patients are at high risk of developing postoperative cognitive dysfunction (POCD) after prolonged exposure to inhaled anesthetics. However, the pathogenesis POCD remains unknown. Hypoxia‑inducible factor‑1α (HIF‑1α) is activated by The aim present study was determine role HIF‑1α in isoflurane‑induced neuroinflammation and resulting impairment. Following a 4‑h 1.5% isoflurane 20‑month‑old rats, increased expression protein, activation nuclear factor (NF)‑κB signaling TNF‑1α were...
Delayed neurocognitive recovery (dNCR) is a common postoperative complication in geriatric surgical patients for which there no efficacious therapy. Cholecystokinin octapeptide (CCK-8), an immunomodulatory peptide, regulates memory and learning. Here, we explored the effects mechanism of action CCK-8 on dNCR.We applied laparotomy to establish model dNCR aged mice. Morris water maze fear conditioning tests were used evaluate cognition. Immunofluorescence was detect density CCK-8, A1 reactive...
Emerging evidence suggests that mitochondrial dysfunction plays a crucial role in the pathogenesis of postoperative delayed neurocognitive recovery (dNCR). Mitochondria exist dynamic equilibrium involves fission and fusion to regulate morphology maintains normal cell function via removal damaged mitochondria through mitophagy. Nonetheless, relationship between mitophagy, how they influence development dNCR, remains poorly understood. Here, we observed morphological alterations mitophagy...
Abstract Background Postoperative sleep disorder (PSD) and delirium, which may be associated with surgery inhalational anesthetics, induce adverse effects in old adults. Emerging evidence indicates that circadian rhythm contributes to various neuropathological diseases, including Alzheimer's disease. Thus, we analyzed the potential role of PSD delirium‐like behavior aged mice determined whether exogenous melatonin could facilitate entrainment after laparotomy under sevoflurane anesthesia....
Background: Little is known about the underlying mechanisms of similarities in core features postoperative delirium (POD) and Alpha-synuclein (α-syn)-related cognitive disorders. We herein investigated associations between fluctuated levels exosomal α-syn plasma POD presentation geriatric hip fracture patients. Methods: conducted an observational, prospective, 1:1 matched (on age older than 65, diagnosis, American Society Anesthesiologists' physical status, duration surgery, intraoperative...
Delayed neurocognitive recovery (dNCR) is a major complication after anesthesia and surgery in older adults. Alpha‐synuclein ( α ‐syn; encoded by the gene, SNCA ) has recently been shown to play an important role hippocampus‐dependent working memory. Aggregated forms of ‐syn are associated with multiple neurotoxic mechanisms, such as mitochondrial dysfunction cell death. In this study, we found that blocking improved both function mitochondria‐dependent neuronal apoptosis mouse model dNCR....
Delayed neurocognitive recovery (dNCR) after surgery is a common postoperative complication in older adult patients. Our previous studies have demonstrated that cognitive impairment involves an increase the brain renin-angiotensin system (RAS) activity, including overactivation of angiotensin 2/angiotensin receptor-1 (Ang II/AT1) axis, which provokes disruption hippocampal blood-brain barrier (BBB). Nevertheless, potential role counter-regulatory RAS Ang-(1–7)/Mas pathway, dNCR remains...
Melatonin exerts many physiological effects via melatonin receptors, among which the melatonin-2 receptor (MT2 ) plays a critical role in circadian rhythm disorders, Alzheimer's disease and other neurological disorders. A replacement strategy has been tested previously, MT2 was target during process. cAMP response element binding (CREB) is an essential transcription factor for memory formation could be involved signalling. Therefore, present study designed to investigate of prophylactic on...
Previous studies have shown multiple mechanisms and pathophysiological changes after anesthesia, genome-wide been implemented in the of brain aging neurodegenerative diseases. However, gene expression patterns modulation networks general anesthesia remains to be elucidated. Therefore, whole transcriptome microarray analysis was used explore coding hippocampus aged rats sevoflurane anesthesia. Six hundred thirty one upregulated 183 downregulated genes were screened out, then 44 enriched terms...
A simple, rapid, and effective cognitive screening test appropriate for fast-paced settings with limited resources staff is essential, especially preoperatively. This study aimed to develop validate the short versions of Mini-Mental State Examination (MMSE) Montreal Cognitive Assessment (MoCA) predicting postoperative delirium (POD) in patients Parkinson's disease (PD) who were scheduled surgery.The current was a secondary analysis data collected from 128 inpatients deep brain stimulation...