A5101825253- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Cervical and Thoracic Myelopathy
- Scoliosis diagnosis and treatment
- Medical Imaging and Analysis
- Musculoskeletal pain and rehabilitation
- Spinal Hematomas and Complications
- Heterotopic Ossification and Related Conditions
- Pelvic and Acetabular Injuries
- Blood transfusion and management
- Nerve Injury and Rehabilitation
- RNA modifications and cancer
- Spinal Cord Injury Research
- Management of metastatic bone disease
- Magnetic properties of thin films
- Case Reports on Hematomas
- Optical Systems and Laser Technology
- Cardiac Health and Mental Health
- Magnetic Field Sensors Techniques
- Endometriosis Research and Treatment
- Phytochemicals and Antioxidant Activities
- Hydraulic and Pneumatic Systems
- Topological Materials and Phenomena
- Wnt/β-catenin signaling in development and cancer
- Trauma, Hemostasis, Coagulopathy, Resuscitation
Peking University Third Hospital
2012-2025
Peking University
2014-2025
Ministry of Education of the People's Republic of China
2022-2024
Collaborative Innovation Center of Advanced Microstructures
2023
Nanjing University
2023
Peking University International Hospital
2017-2022
Jianghan University
2021
Fundación Juan March
2020
Jiangxi Provincial People's Hospital
2010
China-Japan Friendship Hospital
2009
Abstract The topological Hall effect (THE) is critical to the exploration of spin chirality generated by real‐space Berry curvature, which has attracted worldwide attention for its prospective applications in spintronic devices. However, prominent THE remains elusive at room temperature, severely restricts practical integration chiral textures. Here, a colossal intrinsic showed up ≈1.6 µΩ cm large‐area ferromagnet Cr 5 Te 6 thin films epitaxially grown pulsed laser deposition. Such can be...
This was a retrospective review.The aim of this study to examine the epidemiological characteristics and causes spinal cord compression in thoracic stenosis (TSS).As canal is relatively narrow has poor blood supply, severe neurological symptoms may develop if TSS not treated promptly. However, as it rare, less often studied its clinical features are recognized.Between 2005 2012, 427 patients diagnosed with underwent surgery our department. The male female ratio 1.4:1. mean age 53 years. most...
Retrospective study.To investigate the incidence, risk factors, and outcomes of pedicle screw loosening in degenerative lumbar scoliosis (DLS) undergoing long-segment spinal fusion surgery.One hundred thirty DLS patients who underwent surgery with at least a 12-month follow-up were studied. The incidence factors investigated. VAS, SRS-22, ODI scores obtained preoperatively follow-up.One sixty-eight 1784 (9.4%) screws showed evidence 71 (54.6%) patients. Three required revision surgery. Screw...
In Brief Study Design. A case–control association study was conducted to investigate the genetic etiology for ossification of ligamentum flavum (OLF) and posterior longitudinal ligament spine (OPLL). Objective. To determine whether COL6A1 polymorphisms are associated with susceptibility OLF OPLL in Chinese Han population. Summary Background Data. The has been identified as a gene Japanese. may be different among various populations, so we investigated also similar epidemiology, etiology,...
Oxeiptosis is a reactive oxygen species (ROS)-induced pathway of cell death. The involvement circular RNAs (circRNAs) has been confirmed in the incidence and progression intervertebral disc degeneration (IVDD). However, whether oxeiptosis occurs IVDD how circRNAs regulate still unclear. In this study, we discovered that could be induced nucleus pulposus cells (NPCs), circFOXO3 was significantly upregulated after induction. Transfection using small interfering RNA (siRNA) inhibited NPCs....
ABSTRACT Objective High‐grade dysplastic spondylolisthesis (HGDS) is a relatively rare condition mainly involving the L5/S1 segment of spine and occurring in children adolescents. Whether surgical fixation should be L5–S1 monosegmental or extended up to L4 remains controversial. This study aimed compare clinical outcomes risk adjacent between L4–S1 double‐segmental for pediatric HGDS. Methods retrospective control Pediatric patients diagnosed with HGDS March 2007 October 2022 at our hospital...
Abstract Purpose To investigate the association of paraspinal muscle quantity and quality with functional status in patients lumbar spinal stenosis (LSS) explore whether degeneration could predict patients’ recovery. Methods The data 69 (26 males, 43 females; mean age 60.6 ± 9.4 years) LSS was reviewed. total cross-sectional area (tCSA), (fCSA), fatty infiltration (FI) were measured. Oswestry Disability Index (ODI) scores used to reflect status. Correlations between measurements ODI...
Basic experimental study.The aim of this study was to clarify the role macrophages (Mφs) in osteogenic differentiation ligamentum flavum (LF) cells.Mφs and secreted factors are involved regulation cell differentiation, play an important process heterotopic ossification. Whether Mφs development ossification (OLF) have not been reported.The expression CD68+ ossified LF tissue identified by immunohistochemical staining. THP-1 cells were polarized M1 M2, flow cytometry immunofluorescence. The...
A retrospective study to analyze the effect of decompressive extent on posterior shift spinal cord after expansive open-door laminoplasty (ELAP).To investigate distance ELAP, and determine morphologic limitations approach when cervical alignment is lordotic or straight.It still controversial space available for at level cephalad decompression with shift. Moreover, there less understanding regarding significance in relation clinical outcome.Preoperative postoperative MRIs 76 patients a...
In this paper, the authors aimed to summarize clinical characteristics of ossification ligamentum flavum (OLF) associated with dural (DO) and identify improved methods for preoperative diagnosis.Thirty-six patients who had undergone OLF surgery between February 2005 September 2009 were included in retrospective study. The divided into 2 groups: one that intraoperative evidence DO a second group without DO. features summarized neurological status was evaluated pre- postoperatively.The...
Lumbar disk herniation in adults is thought to be caused by repetitive overloading and age-rated degenerative changes. However, these causes are absent children adolescent patients. We assume that structural malformations the lumbar spine could predispose intervertebral disks early degeneration hence need surgically fused. This issue has never been raised before.To investigate assumption fused.Lumbar configurations, including height of intercrestal line, length L5 transverse processes,...
Objective Degenerative thoracolumbar hyperkyphosis (DTH) is a disease that negatively affects individual health and requires surgical intervention, yet the ideal approach complications, especially distal junctional failures (DJF), remain poorly understood. This study aims to investigate DJF in DTH identify risk factors for so we can improve decision‐making, advance our knowledge field of spinal surgery enhance patient outcomes. Methods retrospectively reviewed 78 cases (late osteoporotic...
Paraspinal muscle is an important component to maintain spinal stability. But the relationship between degeneration of paraspinal and postoperative screw loosening in patients with adult degenerative scoliosis has not been studied. The objective this study was investigate risk factors for scoliosis, including degeneration.We investigated 93 who underwent interbody fusion pedicle fixation surgery. lateral curvature located lumbar spine follow-up time ≥ 2 years. were divided into non-loosening...
Background Ossification of ligamentum flavum (OLF) is an insidious and debilitating heterotopic ossifying disease with etiological heterogeneity undefined pathogenesis. Obese individuals predispose to OLF, whereas the underlying connections between obesity phenotype OLF pathomechanism are not fully understood. Therefore, this study aims explore distinct obesity-related genes their functional signatures in OLF. Methods The transcriptome sequencing data related were downloaded from GSE106253...
Thoracic ossification of the ligamentum flavum (TOLF) is a heterotopic spinal ligaments. TOLF major cause thoracic canal stenosis and myelopathy, its underlying mechanisms are not clear. Bone formation complex developmental process involving differentiation mesenchymal stem cells to osteoblasts, regulated by BMP2, RUNX2, Osterix (OSX), etc. In this study, we continue further characterize properties TOLF. Our immunohistochemistry experiments showed that expressions osteoblastic factors such...
Given the aging Chinese population and inevitable degenerative process of spine, more elderly patients with spinal disease (SDD) are surgical candidates, placing a significant burden on health care resources. Few studies have investigated recent trends in hospital admissions procedures for SDD China. This study aimed to identify trends, if any, number undertaken large patient cohort.This retrospective cohort analysis used data from inpatient medical records at Peking University Third...
Abstract Thoracic ossification of the ligamentum flavum (TOLF) is ectopic spinal ligaments. Histologically, development TOLF can be described as process endochondral ossification. However, underlying aetiology has not been completely clarified. In this investigation, gene expression profile associated with leucine‐rich repeat‐containing G‐protein‐coupled receptors (LGR) and Wnt signalling pathway in thoracic cells (TLFCs) different stages was analysed via RNA sequencing. We further confirmed...
A clinical study.To measure the changes in pulmonary function and thoracic volume associated with surgical correction of kyphotic deformities.No prior study has focused on cavity before after corrective surgery for kyphosis.Thirty-four patients kyphosis underwent posterior deformity instrumented fusion. Preoperative postoperative was measured, grade evaluated as mild, significant, or severe. The change preoperative to analyzed, using 6 comparative subgroupings basis age, severity kyphosis,...
Object The primary object of this investigation was to study recombinant human bone morphogenetic protein–2 (rhBMP-2)–induced ossification the ligamentum flavum and associated histone H3 modification in a rat model. In an additional set studies authors investigated spinal cord behavioral changes same Methods report on 2 separate sets studies. A total 90 rats were used for (45 each); each study, lyophilized rhBMP-2 collagen mixture (20 μg 200 μl collagen) implanted lumbar extradural space 18...
Retrospective cohort study.
Study Design. A retrospective study. Objective. The aim of this study was to evaluate the factors affecting health-related quality life (HRQOL) after surgery in patients with degenerative lumbar scoliosis (DLS) by minimum clinically important difference (MCID). Summary Background Data. MCID has been introduced adult spinal deformity quantify absolute change that can be considered a success. There are limited data available identify reaching DLS surgery. Methods. This reviewed cohort 123...