<h3>Objective</h3> To assess whether global or regional changes in amyloid burden over 4 years predict early declines episodic memory initially amyloid-negative adults. <h3>Methods</h3> One hundred twenty-six amyloid-negative, cognitively normal participants (age 30–89 years) were included from the Dallas Lifespan Brain Study who completed florbetapir PET and a cognitive battery at baseline 4-year follow-up. Standardized uptake value ratio (SUVR) change was computed across 8 bilateral...

<h3>Importance</h3> Presently, the clinical standard for reporting results of an amyloid positron emission tomography scan is to assign a dichotomous rating positive or negative presence amyloid. In 4-year longitudinal study, we investigated whether using continuous measure magnitude baseline burden would provide valuable information about rate future cognitive decline over subsequent 4 years compared with in middle-aged and older adults. <h3>Objective</h3> To examine continuous,...

Background With the disappointing outcomes of clinical trials on patients with Alzheimer's disease or mild cognitive impairment (MCI), there is increasing attention to understanding decline in normal elderly individuals, goal identifying subjects who are most susceptible imminent impairment. Purpose/Hypothesis To evaluate potential cerebral blood flow (CBF) as a biomarker by investigating relationship between CBF at baseline and cognition follow‐up. Study Type Prospective longitudinal study...

Studies suggest that tau deposition starts in the anterolateral entorhinal cortex (EC) with normal aging, and presence of β-amyloid (Aβ) facilitates its spread to neocortex, which may reflect beginning Alzheimer's disease (AD). Functional connectivity between EC anterior-temporal (AT) memory network appears drive higher AT than posterior-medial (PM) network. Here, we investigated whether this differential vulnerability predict different cognitive consequences EC, AT, PM tau. Using 18...

Abstract In presymptomatic Alzheimer’s disease (AD), beta-amyloid plaques (Aβ) and tau tangles accumulate in distinct spatiotemporal patterns within the brain, tracking closely with episodic memory decline. Here, we tested whether age-related changes segregation of brain’s intrinsic functional networks—anterior-temporal (AT) posterior-medial (PM) networks—are associated accumulation Aβ, tau, decline using fMRI PET. We found that AT PM networks were less segregated older than younger adults...

High-quality tea leaves are required for matcha production. Shading is one of the key agronomic practices that can increase quality green tea. The objectives among producers include increasing ammonia and chlorophyll contents buds, decreasing polyphenol contents, enhancing aroma formation. In this study, Fuding white plants were cultivated under open-air conditions (control) as well 85% (S85) 95% (S95) shade. highest S85 treatment, followed by S95 control treatments. Moreover, shading...

The dietary intervention has demonstrated effectiveness in improving hyperlipidemia and obesity. Woody edible oils are rich unsaturated fatty acids (UFAs) that could positively affect lipid metabolism. In this study, the blended oil (BLO), a balanced UFA supplement, constituted by Zanthoxylum bungeanum (Chinese Red Pepper) seed oil, walnut (Juglans regia) camellia (Camema oleifera) perilla (Perilla frutescens) was established referring to Chinese reference intakes, which ratios of...

Objective Tau pathology is recognized as a primary contributor to neurodegeneration and clinical symptoms in Alzheimer's disease (AD). This study aims localize the early tau cognitively normal older people that predictive of subsequent memory decline, delineate factors underlying tau‐related decline individuals with without β‐amyloid (Aβ). Methods A total 138 from Berkeley Aging Cohort Study underwent 11 C‐Pittsburgh Compound‐B (PiB) positron emission tomography (PET) determine Aβ positivity...

To explore the effect of different microbial strains on blueberry pomace with solid-state fermentation (SSF), three fungi and lactic acid bacteria (LAB) were utilized to investigate respect polyphenol profiles, antioxidant capacities, bioaccessibility. Different exhibited capacities for metabolizing polyphenolic compounds in pomace. The contents 10 phenolic acids 6 flavonoids (except (+)-catechin) increased fermented by Lactobacillus acidophilus (LA). A similar tendency was observed...

Oxeiptosis is a reactive oxygen species (ROS)-induced pathway of cell death. The involvement circular RNAs (circRNAs) has been confirmed in the incidence and progression intervertebral disc degeneration (IVDD). However, whether oxeiptosis occurs IVDD how circRNAs regulate still unclear. In this study, we discovered that could be induced nucleus pulposus cells (NPCs), circFOXO3 was significantly upregulated after induction. Transfection using small interfering RNA (siRNA) inhibited NPCs....

Synaptic density imaging with PET is a relatively new approach to monitoring synaptic injury in neurodegenerative diseases. However, there are remaining technical and clinical questions, including questions on reference region selection how specific phenotypic presentations symptoms of Alzheimer disease (AD) reflected alterations density. Methods: Using vesicle glycoprotein 2A (SV2A) ligand radiolabeled the 18F isotope ([18F]SynVesT-1), we performed sensitivity analyses determine optimal...

Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL Happiness the Air: How Does a Dirty Sky Affect Subjective Well-Being? 53 Pages Posted: 4 Sep 2015 See all articles by Xin ZhangXin ZhangBeijing Normal University (BNU) - School of StatisticsXiaobo ZhangInternational Food Policy Research Institute (IFPRI)Xi ChenYale Public Health Department and Management; Yale Economics; Institution for Social...

Abstract Speakers rapidly adjust their ongoing vocal productions to compensate for errors they hear in auditory feedback. It is currently unclear what role attention plays these compensations. This event‐related potential ( ERP ) study examined the influence of selective and divided on cortical responses pitch heard feedback regarding vocalisations. During production a sustained vowel, participants briefly shifted up two semitones while actively attended or visual events (selective...

A critical skill in emergent writing is the developing ability to take perspective of different readers; however, precursors this have not yet been identified. In longitudinal study, 105 children (90 after attrition) were tested at 3 time points: pre-kindergarten (3–4 years old, n = 105), kindergarten (5 97), and Grade 1 (6–7 90). Theory mind (ToM) significantly predicted children's awareness a reader's epistemic state when they dictated letters both even controlling for language (Peabody...

&lt;b&gt;&lt;i&gt;Background:&lt;/i&gt;&lt;/b&gt; An important aspect of successful aging is maintaining the ability to solve everyday problems encountered in daily life. The limited evidence today suggests that problem solving increases from young adulthood middle age, but decreases older age. &lt;b&gt;&lt;i&gt;Objectives:&lt;/i&gt;&lt;/b&gt; present study examined age differences relative contributions fluid and crystallized abilities on Everyday Problems Test (EPT). We hypothesized due...

Much neuroimaging research has explored the neural mechanisms underlying successful cognitive aging. Two different patterns of functional activation, maintenance youth-like activity and compensatory novel recruitment, have been proposed to represent brain features individual differences in In this study, we investigated individuals across adult lifespan who appeared resist age-related decline, comparison those with typical declines, over course four years. We first implemented latent mixture...

The fornix and parahippocampal cingulum are 2 major limbic tracts in the core memory network of hippocampus. Although these fiber known to degrade with Alzheimer's disease (AD), little is about their vulnerability asymptomatic phase AD. In this longitudinal study cognitively normal adults, we assessed amyloid-beta (Aβ) plaques using positron emission tomography white matter microstructure diffusion tensor imaging. We found that an increase neocortical Aβ burden over time was associated...