A5101771578- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Cervical and Thoracic Myelopathy
- Scoliosis diagnosis and treatment
- Heterotopic Ossification and Related Conditions
- Spinal Hematomas and Complications
- Infectious Diseases and Tuberculosis
- Surgical site infection prevention
- TGF-β signaling in diseases
- Wnt/β-catenin signaling in development and cancer
- Bone and Joint Diseases
- Bone Tissue Engineering Materials
- Developmental Biology and Gene Regulation
- Musculoskeletal pain and rehabilitation
- Bone fractures and treatments
- Galectins and Cancer Biology
- Genetic Syndromes and Imprinting
- Hedgehog Signaling Pathway Studies
- Spinal Cord Injury Research
- Turtle Biology and Conservation
- Bone health and osteoporosis research
- Anesthesia and Pain Management
- Management of metastatic bone disease
- Pregnancy-related medical research
- RNA modifications and cancer
Peking University Third Hospital
2016-2025
Ministry of Education of the People's Republic of China
2022-2025
Peking University
2016-2025
Spinal Research
2022
Retrospective review.To perform a single-institution analysis of incidence, treatment, and clinical outcome in patients with thoracic ossification the ligamentum flavum (OLF) who experienced dural tears cerebrospinal fluid (CSF) leakage.There is paucity reports focusing on CSF leakage after OLF surgery. Because adhesion are common features OLF, incidence high represents significant challenge.A total 266 were admitted to our hospital from 1995 2011. Each patient's medical records reviewed...
In vivo assessment of a novel artificial vertebral body fabricated by electron beam melting (EBM) for cervical replacement in sheep model.To investigate the feasibility body: "self-stabilizing body" (SSAVB) EBM model.Artificial is widely used and spinal fusion, but research on an has not been reported.An SSAVB made porous Ti6Al4V was implanted into spine to replace C4 6 12 weeks. Bone ingrowth implant stability were radiologically evaluated, histological biomechanical tests performed.No...
This was a retrospective review.The aim of this study to examine the epidemiological characteristics and causes spinal cord compression in thoracic stenosis (TSS).As canal is relatively narrow has poor blood supply, severe neurological symptoms may develop if TSS not treated promptly. However, as it rare, less often studied its clinical features are recognized.Between 2005 2012, 427 patients diagnosed with underwent surgery our department. The male female ratio 1.4:1. mean age 53 years. most...
ABSTRACT Objective High‐grade dysplastic spondylolisthesis (HGDS) is a relatively rare condition mainly involving the L5/S1 segment of spine and occurring in children adolescents. Whether surgical fixation should be L5–S1 monosegmental or extended up to L4 remains controversial. This study aimed compare clinical outcomes risk adjacent between L4–S1 double‐segmental for pediatric HGDS. Methods retrospective control Pediatric patients diagnosed with HGDS March 2007 October 2022 at our hospital...
Ossification of the ligamentum flavum (OLF) is a disorder heterotopic ossification spinal ligaments and main cause thoracic canal stenosis. Previous studies suggested that miR-132-3p negatively regulates osteoblast differentiation. However, whether involved in process OLF has not been investigated. In this study, we investigated effect its target genes forkhead box O1 (FOXO1), growth differentiation factor 5 (GDF5) SRY-box 6 (SOX6) on osteogenic (LF) cells. We demonstrated was down-regulated...
Sustainable release of simvastatin from poloxamer 407 hydrogel in 3D-printed porous Ti6Al4V for spinal fusion rhesus macaques.
Oxeiptosis is a reactive oxygen species (ROS)-induced pathway of cell death. The involvement circular RNAs (circRNAs) has been confirmed in the incidence and progression intervertebral disc degeneration (IVDD). However, whether oxeiptosis occurs IVDD how circRNAs regulate still unclear. In this study, we discovered that could be induced nucleus pulposus cells (NPCs), circFOXO3 was significantly upregulated after induction. Transfection using small interfering RNA (siRNA) inhibited NPCs....
Abstract Ossification of the ligamentum flavum (OLF) is a pathology almost only reported in East Asian countries. The leading cause OLF thoracic spinal canal stenosis and myelopathy. In this study, role miR‐199b‐5p jagged 1 (JAG1) primary cell osteogenesis was examined. MiR‐199b‐5p found to be down‐regulated during osteogenic differentiation cells, while overexpression inhibited differentiation. addition, JAG1 up‐regulated knockdown via RNA interference caused an inhibition Notch signalling...
Mechanical stress and genetic factors play important roles in the occurrence of thoracic ossification ligament flavum (TOLF), which can occur at one, two, or multiple levels spine. It is unclear whether single- multiple-level TOLF differ terms osteogenic differentiation potency osteogenesis-related gene expression under cyclic mechanical stress. This was addressed present study using patients with non‑TOLF single‑ multiple‑level (n=8 per group). Primary cells were cultured osteogenesis...
In this paper, the authors aimed to summarize clinical characteristics of ossification ligamentum flavum (OLF) associated with dural (DO) and identify improved methods for preoperative diagnosis.Thirty-six patients who had undergone OLF surgery between February 2005 September 2009 were included in retrospective study. The divided into 2 groups: one that intraoperative evidence DO a second group without DO. features summarized neurological status was evaluated pre- postoperatively.The...
Lumbar disk herniation in adults is thought to be caused by repetitive overloading and age-rated degenerative changes. However, these causes are absent children adolescent patients. We assume that structural malformations the lumbar spine could predispose intervertebral disks early degeneration hence need surgically fused. This issue has never been raised before.To investigate assumption fused.Lumbar configurations, including height of intercrestal line, length L5 transverse processes,...
ABSTRACT This study investigated the pathological process of Notch signaling in osteogenesis ligamentum flavum tissues and cells, associated regulatory mechanisms. receptors, ligands, target genes were identified by quantitative polymerase chain reaction (qPCR) cells immunohistochemistry sections from ossification (OLF) patients controls. The temporospatial expression patterns JAG1/Notch2/HES1 human during osteogenic differentiation determined qPCR. Lentiviral vectors for Notch2...
Thoracic ossification of the ligamentum flavum (TOLF) causes serious spinal canal stenosis. The underlying aetiology may relate to genetic and inflammatory factors. DNA methylation plays a critical role in osteogenesis inflammation, whereas there is no genome-wide analysis about TOLF. two subtypes TOLF (single-level multiple-level) have distinct clinical features. Using micro-computed tomography (micro-CT), we showed arose from joint between vertebrae at one/both sides ligament flavum. With...
Background Ossification of ligamentum flavum (OLF) is an insidious and debilitating heterotopic ossifying disease with etiological heterogeneity undefined pathogenesis. Obese individuals predispose to OLF, whereas the underlying connections between obesity phenotype OLF pathomechanism are not fully understood. Therefore, this study aims explore distinct obesity-related genes their functional signatures in OLF. Methods The transcriptome sequencing data related were downloaded from GSE106253...
Abstract Background Thoracic spinal stenosis (TSS) is a rare but intractable disease that fails to respond conservative treatment. decompression, which traditionally performed using high-speed drills and Kerrison rongeurs, time-consuming technically challenging task. Unfavorable outcomes high incidence of complications are the major concerns. The development adaptation ultrasonic bone scalpel (UBS) have promoted its application in various operations, standard operating procedure thoracic...