A5100458204- Bone Metabolism and Diseases
- Heterotopic Ossification and Related Conditions
- Cervical and Thoracic Myelopathy
- Liver Disease and Transplantation
- Venous Thromboembolism Diagnosis and Management
- Bone health and treatments
- Liver Disease Diagnosis and Treatment
- Blood transfusion and management
- TGF-β signaling in diseases
- Spine and Intervertebral Disc Pathology
- Wnt/β-catenin signaling in development and cancer
- Neurogenetic and Muscular Disorders Research
- Gastric Cancer Management and Outcomes
- Reconstructive Surgery and Microvascular Techniques
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Organ Transplantation Techniques and Outcomes
- Atrial Fibrillation Management and Outcomes
- Gallbladder and Bile Duct Disorders
- Cancer, Hypoxia, and Metabolism
- Pelvic floor disorders treatments
- Bone and Joint Diseases
- Endometriosis Research and Treatment
- Inflammatory mediators and NSAID effects
- Osteoarthritis Treatment and Mechanisms
- Hip disorders and treatments
Peking University
2016-2024
Peking University International Hospital
2016-2024
Second Hospital of Shandong University
2024
Northern Jiangsu People's Hospital
2024
Dalian Municipal Central Hospital
2024
Yangzhou University
2018-2023
Beijing University of Chinese Medicine
2020-2023
Chinese Institute for Brain Research
2023
Second Affiliated Hospital of Zhejiang University
2020
Affiliated Hospital of Zunyi Medical College
2019
Purpose The objective of this study was to investigate the risk cardiovascular toxicities related PD-1/PD-L1 inhibitors in solid tumors. Methods A literature search performed following participants, interventions, comparisons, outcomes, and design (PICOS) principles, adhered Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) guidelines. Data analysis conducted using Review Manager version 5.4. Results This meta-analysis included 69 randomized controlled trials (RCTs)...
Osterix (Osx) is an osteoblast-specific transcription factor required for bone formation and osteoblast differentiation. The critical step in to replace the avascular cartilage template with vascularized bone. Osteogenesis angiogenesis are associated each other, sharing some essential regulators. Vascular endothelial growth (VEGF) involved both osteogenesis. Transcriptional regulation of VEGF expression not well known osteoblasts. In this study, quantitative real-time RT-PCR results revealed...
Natural bone apatite crystals, which mediate the development and regulate load-bearing function of bone, have recently been associated with strongly bound citrate molecules. However, such understanding has not translated into biomaterial design osteoblast cell culture. In this work, we developed a new class biodegradable, mechanically strong, biocompatible citrate-based polymer blends (CBPBs), offer enhanced hydroxyapatite binding to produce more biomimetic composites (CBPBHAs) for...
Osterix (Osx) is an osteoblast-specific transcription factor required for osteoblast differentiation. Inhibition of Wnt pathway by Osx highlights the potential feedback control mechanisms involved in bone formation. Hypoxia-inducible factor-1α (HIF-1α) a master regulator hypoxia. HIF-1α has been reported to couple angiogenesis osteogenesis. Our recent study demonstrated that and cooperatively regulate VEGF expression osteoblasts. Effects hypoxia/HIF-1α on proliferation related are not well...
Osterix (Osx) is an osteoblast-specific transcription factor required for osteoblast differentiation from mesenchymal stem cells. In Osx knock-out mice, no bone formation occurs. The vitamin D receptor (VDR) a member of the nuclear hormone superfamily that regulates target gene to ensure appropriate control calcium homeostasis and development. Here, we provide several lines evidence show VDR transcriptional regulation by in osteoblasts. For example, calvaria obtained Osx-null embryos...
Thoracic ossification of the ligamentum flavum (TOLF) is characterized by ectopic bone formation in and considered to be a leading cause thoracic spinal canal stenosis myelopathy. However, underlying etiology not well understood. An iTRAQ proteomics was used reveal involvement inflammation factors TOLF. TNF-α pro-inflammatory cytokine implicated pathogenesis many human diseases. Protein profiling analysis showed that protein level increased ossified TOLF, which confirmed western blot. The...
Mechanical stress and genetic factors play important roles in the occurrence of thoracic ossification ligament flavum (TOLF), which can occur at one, two, or multiple levels spine. It is unclear whether single- multiple-level TOLF differ terms osteogenic differentiation potency osteogenesis-related gene expression under cyclic mechanical stress. This was addressed present study using patients with non‑TOLF single‑ multiple‑level (n=8 per group). Primary cells were cultured osteogenesis...
Kidney‑type glutaminase (GLS1) plays a significant role in tumor metabolism. Our recent studies demonstrated that GLS1 was aberrantly expressed hepatocellular carcinoma (HCC) and facilitated progression. However, the roles of intrahepatic cholangiocarcinoma (ICC) remain largely unknown. Thus, aim this study to evaluate expression clinical significance ICC. For purpose, combined data from Oncomine database with those immunohistochemistry were used determine levels cancerous non‑cancerous...
Abstract Growth differentiation factor 11 (GDF11) is a member of the transforming growth factor‐β super family. It has multiple effects on development, physiology and diseases. However, role GDF11 in development mesenchymal stem cells (MSCs) not clear. To explore pro‐angiogenic activities MSCs, mouse bone marrow–derived MSCs were engineered to overexpress (MSC ) their capacity for paracrine actions examined both vitro vivo. Expression endothelial markers CD31 VEGFR2 at levels mRNA protein...
There has been no effective method to monitor the changes of blood coagulation after thromboprophylaxis for elective arthroplasty patients. The objective this study is assess status patients undergoing with thromboelastograph (TEG). Ninety primary unilateral were investigated. Thromboprophylaxis continued at least 10 days. TEG was performed on day before operation and postoperative days 1, 4, 9. total hip knee groups showed significant in distribution different hypercoagulable states 1–4...
Background Previous studies have suggested an association between gut microbiota and primary biliary cholangitis (PBC). Nonetheless, the causal relationship PBC risk remains unclear. Methods A bidirectional two-sample Mendelian Randomization (MR) study was employed using summary statistical data for from MiBioGen consortium Genome-Wide Association Studies (GWAS) database to investigate relationships 211 risk. Inverse variance weighted (IVW) method analytical approach assess causality,...
Osteoarthritis (OA) is the most prevalent degenerative joint disease.The highly regulated balance of matrix synthesis and degradation disrupted in OA, leading to progressive breakdown articular cartilage.The molecular events pathways involved chondrocyte disfunction cartilage OA are not fully understood.It known that 1,25-dihydroxyvitamin D₃ (1,25-(OH) 2 D 3 ) synthesized by macrophages derived from synovial fluid patients with inflammatory arthritis.Vitmain receptor expressed chondrocytes...
Thoracic ossification of the ligamentum flavum (TOLF) is a heterotopic spinal ligaments. TOLF major cause thoracic canal stenosis and myelopathy, its underlying mechanisms are not clear. Bone formation complex developmental process involving differentiation mesenchymal stem cells to osteoblasts, regulated by BMP2, RUNX2, Osterix (OSX), etc. In this study, we continue further characterize properties TOLF. Our immunohistochemistry experiments showed that expressions osteoblastic factors such...
Thoracic ossification of the ligamentum flavum (TOLF) is a rare heterotopic spinal ligaments, which major cause thoracic canal stenosis and myelopathy.In this study, roles miR-490-3p forkhead box O1 (FOXO1) in osteogenesis human cells were investigated.MiR-490-3p was found to be down-regulated during osteogenic differentiation cells, while their overexpression inhibited differentiation.In addition, analysis target prediction dual luciferase reporter assays supported that directly targeted...
Abstract Thoracic ossification of the ligamentum flavum (TOLF) is ectopic spinal ligaments. Histologically, development TOLF can be described as process endochondral ossification. However, underlying aetiology has not been completely clarified. In this investigation, gene expression profile associated with leucine‐rich repeat‐containing G‐protein‐coupled receptors (LGR) and Wnt signalling pathway in thoracic cells (TLFCs) different stages was analysed via RNA sequencing. We further confirmed...
Heterotopic ossification of the elbow (HOE) is a complicated pathologic process characterized by extra bone formation in elbow. Bone complex developmental involving differentiation mesenchymal stem cells into osteoblasts. The aim this study was to explore cellular origin and progression HOE single-cell RNA sequencing. We identified 13 clusters further analyzed subclusters for 4 main cell types. Six osteoblasts, nine chondrocytes, six fibroblasts, five mononuclear phagocytes (MPs) were...