A5102941129- HIV Research and Treatment
- Drug Transport and Resistance Mechanisms
- Alzheimer's disease research and treatments
- Barrier Structure and Function Studies
- Autophagy in Disease and Therapy
- Hydrology and Watershed Management Studies
- Fish Ecology and Management Studies
- Hydrology and Sediment Transport Processes
- Aortic aneurysm repair treatments
- HIV-related health complications and treatments
- Caveolin-1 and cellular processes
- Electrospun Nanofibers in Biomedical Applications
- Pharmacological Effects and Toxicity Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Salivary Gland Disorders and Functions
- Wound Healing and Treatments
- Lysosomal Storage Disorders Research
- Cytokine Signaling Pathways and Interactions
- Tendon Structure and Treatment
- Adenosine and Purinergic Signaling
- Diet and metabolism studies
- Menopause: Health Impacts and Treatments
- Hormonal Regulation and Hypertension
- Kruppel-like factors research
- Trace Elements in Health
University of Kentucky
2009-2023
Jiangxi Pingxiang People's Hospital
2023
Southern Medical University
2019-2022
Nanfang Hospital
2019-2022
The Affiliated Yongchuan Hospital of Chongqing Medical University
2016-2022
Chongqing Medical University
2016-2022
Weifang Maternity and Child Care Hospital
2020
Institute of Biophysics
2017-2018
The First Affiliated Hospital, Sun Yat-sen University
2012-2017
Sun Yat-sen University
2012-2017
Failure to clear amyloid-β (Aβ) from the brain is in part responsible for Aβ accumulation Alzheimer's disease (AD). A critical protein clearing across blood–brain barrier efflux transporter P-glycoprotein (P-gp) luminal plasma membrane of capillary endothelium. P-gp reduced at AD, which has been shown be associated with accumulation. However, mechanism reduction AD not well understood. Here we focused on identifying mechanistic steps involved reducing AD. We exposed isolated rat capillaries...
The blood–brain barrier (BBB) is the critical structure for preventing human immunodeficiency virus (HIV) trafficking into brain. Specific HIV proteins, such as Tat protein, can contribute to dysfunction of tight junctions at BBB and entry released by HIV-1-infected cells interact with a variety cell surface receptors activating several signal transduction pathways, including those localized in caveolae. present study focused on mechanisms Tat-induced caveolae-associated Ras signaling level...
Neurovascular integrity plays an important role in protecting cognitive and mental health aging. Lifestyle interventions that sustain neurovascular may thus be critical on preserving brain functions aging reducing the risk for age-related neurodegenerative disorders. Here we show caloric restriction (CR) had early effect enhancements, played a vascular, In particular, found CR significantly enhanced cerebral blood flow (CBF) blood-brain barrier function young mice at 5-6 months of age. The...
A cure for epilepsy is currently not available, and seizure genesis, recurrence, resistance to antiseizure drugs remain serious clinical problems. Studies show that the blood-brain barrier altered in animal models of epileptic patients. In this regard, seizures increase expression efflux transporters such as P-glycoprotein (P-gp), which thought reduce brain uptake drugs, thus, contribute drug resistance. The goal current study was assess viability combining vivo ex preparations isolated...
The human immunodeficiency virus (HIV)-specific protein trans-activator of transcription (Tat) can contribute to the dysfunction brain endothelial cells and HIV trafficking into by disrupting tight junction (TJ) integrity at blood–brain barrier (BBB) level. Specific TJ proteins, such as zonula occludens (ZO) localize not only cell–cell borders but are also present in nuclei. objective study was evaluate mechanisms significance Tat-induced nuclear localization ZO-1. Treatment a cell line...
Osterix (Osx) is an osteoblast-specific transcription factor required for osteoblast differentiation. Inhibition of Wnt pathway by Osx highlights the potential feedback control mechanisms involved in bone formation. Hypoxia-inducible factor-1α (HIF-1α) a master regulator hypoxia. HIF-1α has been reported to couple angiogenesis osteogenesis. Our recent study demonstrated that and cooperatively regulate VEGF expression osteoblasts. Effects hypoxia/HIF-1α on proliferation related are not well...
The Rho signaling has an essential function in human immunodeficiency virus (HIV)-1-mediated disruption of the integrity blood–brain barrier (BBB). However, it is unknown how membrane domains, such as lipid rafts, can influence HIV-1-mediated activation pathway and these processes affect expression efflux transporters at BBB level. This study focused on HIV-1 protein Tat upregulation P-glycoprotein (P-gp) brain endothelial cells. Treatment with markedly elevated GTP-RhoA levels potential...
One characteristic of Alzheimer's disease (AD) is excessive accumulation amyloid-β (Aβ) in the brain. Aβ brain is, part, due to a reduction clearance from across blood-brain barrier. key element that contributes P-glycoprotein (P-gp) transports blood. In AD, P-gp protein expression and transport activity levels are significantly reduced, which impairs clearance. The mechanism responsible for reduced poorly understood. We recently demonstrated Aβ40 triggers degradation through...
Objective— Abdominal aortic aneurysm (AAA) has high mortality rate when ruptured, but currently, there is no proven pharmacological therapy for AAA because of our poor understanding its pathogenesis. The current study explored a novel role smooth muscle cell (SMC) BMAL1 (brain and Arnt-like protein-1)—a transcription factor known to regulate circadian rhythm—in development. Approach Results— SMC-selective deletion potently protected mice from induced by (1) MR (mineralocorticoid receptor)...
Abstract Background Loss of P-glycoprotein (P-gp) at the blood–brain barrier contributes to amyloid-β (Aβ) brain accumulation in Alzheimer’s disease (AD). Using transgenic human amyloid precursor protein (hAPP)-overexpressing mice (Tg2576), we previously showed that Aβ triggers P-gp loss by activating ubiquitin–proteasome pathway, which leads degradation. Furthermore, inhibiting ubiquitin-activating enzyme (E1) prevents and lowers hAPP mice. Based on these data, hypothesized repurposing...
In this paper, we describe a model system comprised of hydrodynamic, sediment transport, heat transfer and habitat models. We used to assess the ecosystem situation investigate impacts two ecological restoration strategies in Mian River, China. Freshwater Reeves shad (Tenualosa reevesii) was selected as target fish species. Model results indicate low suitability level for T. reevesii under current hydrological conditions. Due protection requirements China, further numerical simulations were...
Abstract Background Failure to clear Aβ from the brain is partly responsible for accumulation in Alzheimer’s disease (AD). A critical protein clearing across blood-brain barrier efflux transporter P-glycoprotein (P-gp). In AD, P-gp levels are reduced, which contributes impaired clearance. However, mechanism decreased poorly understood and there no strategies available protect P-gp. We previously demonstrated isolated capillaries ex vivo that human Aβ40 (hAβ40) triggers degradation by...
Understanding blood-brain barrier function under physiological and pathophysiological conditions is critical for the development of new therapeutic strategies that hold promise to enhance brain drug delivery, improve protection, treat disorders.However, studying human challenging.Thus, there a need appropriate models.In this regard, capillaries isolated from tissue represent unique tool study as close in vivo situation possible.Here, we describe an optimized protocol isolate at high yield...
Objective: The clinical course of unconsciousness after traumatic brain injury (TBI) is commonly unpredictable and it remains a challenge with limited therapeutic options. aim this study was to evaluate the early changes in serum sex hormone levels severe TBI (sTBI) use these hormones predict recovery from regard sex. Methods: We performed retrospective including patients sTBI. A statistical analysis consciousness at six months made identify effective prognostic indicators. Results:...
The Dsb protein family is responsible for introducing disulfide bonds into nascent proteins in prokaryotes, stabilizing the structure of many proteins. Helicobacter pylori HP0231 a Dsb-like protein, shown to catalyze bond formation and participate redox homeostasis. Notably, H. virulence factors are stabilized by bonds. By employing deficient strains we analyzed effect lack this bacterial on functionality containing putative impaired CagA translocation gastric epithelial cells reduced...
High flow generates significant alterations in downstream river reaches, resulting physical condition changes the regions of such as water depth, velocity, temperature and bed. These will lead to change fish habitat configuration river. This paper proposes a model system evaluate high effects on substrates changes, distribution consequently assess spawning juvenile rainbow trout (Oncorhynchus mykiss) habitats region Glen Canyon Dam. Firstly, based 2 dimensional (2D) depth-averaged CFD...
We aimed at exploring the function of microRNA-324/cytokine signaling 3 (miR-324/SOCS3) axis in hypoxia/reoxygenation (H/R) -induced cardiomyocyte injury and its underlying mechanism. The differential expression genes were analyzed based on GSE83500 GSE48060 datasets from Gene Expression Omnibus (GEO) database. Then, to conduct enrichment analysis, Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) databases used. upstream regulatory microRNAs (miRNAs) identified predicted by miRanda,...