A5100410586- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Cardiac Fibrosis and Remodeling
- Acute Myocardial Infarction Research
- Cytomegalovirus and herpesvirus research
- Peptidase Inhibition and Analysis
- Radiomics and Machine Learning in Medical Imaging
- Diabetes Treatment and Management
- Protease and Inhibitor Mechanisms
- Cardiac Health and Mental Health
- Health, Environment, Cognitive Aging
- Blood Pressure and Hypertension Studies
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Health and Risk Factors
- Viral Infections and Immunology Research
- Cardiac Valve Diseases and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Syncope and Autonomic Disorders
- Cardiac Structural Anomalies and Repair
- Cardiovascular Disease and Adiposity
- Venous Thromboembolism Diagnosis and Management
- Herpesvirus Infections and Treatments
Central Hospital of Wuhan
2024
Putian University
2020-2024
Fujian Medical University
2011-2024
First People's Hospital of Chongqing
2024
Georgetown University Medical Center
2024
Georgetown University
2024
Huazhong University of Science and Technology
2020-2024
Exact Sciences (United States)
2023-2024
XinHua Hospital
2023
Shanghai Jiao Tong University
2023
Dapagliflozin (DAPA) has been reported to have significant cardiac protective effects on heart failure (HF). However, the dose and time, as well underlying mechanisms, for DAPA treatment in acute myocardial infarction (AMI) remain controversial. The aim of this study aimed assess efficacy safety along with an increased concentration gradient AMI explore potential mechanisms.
The systemic immune-inflammation index (SII), as a novel inflammatory biomarker, has recently attracted attention in cardiovascular disease research. However, the relationship between SII and risk of lower extremity deep venous thrombosis (LEDVT) remains unclear to date. Thus, this study aimed explore association large sample over 10-year period (2012-2022).All hospitalized patients undergoing compression ultrasonography (CUS) examination were consecutively screened by searching our hospital...
This research aimed to (i) determine the prevalence of metabolic syndrome (MetS) and its components; (ii) assess factors associated with MetS, (iii) define optimal ethnic-specific cutoffs obesity- atherogenic-based markers predict MetS among postmenopausal women in rural Canton.The Rural Canton Diabetes Metabolic Disorders Study, a population based cross-sectional study, was conducted during 2011-2012 Canton. In person interviews, blood glucose lipid measurements were completed for 4,706 who...
Angiopoietin-like protein 8 (ANGPTL8), an important regulator of lipid metabolism, is increased in diabetes and associated with insulin resistance. However, the role ANGPTL8 outcomes diabetic patients remains unclear. This study aimed to investigate circulating levels participants without its potential associations clinical a 5 year cohort study.Propensity-matched cohorts subjects from Risk Evaluation Cancers Chinese Diabetic Individuals: A longitudinal (REACTION) were generated on basis...
Herpes simplex virus type 1 (HSV-1) is widespread double-stranded DNA (dsDNA) that establishes life-long latency and causes diverse severe symptoms. The mechanisms of HSV-1 infection HSV-1's interactions with various host cells have been studied reviewed extensively. Type I interferons were secreted by upon HSV play a vital role in controlling proliferation. A few studies, however, focused on without the presence interferon (IFN) signaling. In this study, HEK 293T low toll-like receptor...
We aimed at exploring the function of microRNA-324/cytokine signaling 3 (miR-324/SOCS3) axis in hypoxia/reoxygenation (H/R) -induced cardiomyocyte injury and its underlying mechanism. The differential expression genes were analyzed based on GSE83500 GSE48060 datasets from Gene Expression Omnibus (GEO) database. Then, to conduct enrichment analysis, Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) databases used. upstream regulatory microRNAs (miRNAs) identified predicted by miRanda,...
Background: Pirarubicin (THP), an analogue of doxorubicin, has exhibited promising activities against acute leukemia, malignant lymphoma, and several solid tumors. However, the cumulative cardiotoxicity limits its wide application in chemotherapy. Method: To provide alternative strategy for reducing cardiotoxicity, a novel THP liposome powder (L-THP), comprising distearoylphosphatidylcholine, distearoylphosphatidylglycerol, cholesterol, lactose was appropriately prepared based on...
Acute disseminated encephalomyelitis (ADEM) is an inflammatory, demyelinating disease occurring several weeks after viral infection. Enteroviruses have been described as potential triggers of ADEM, but the closely related parechoviruses not. The objective study to assess prevalence and presentation ADEM parechovirus infection in a syndromic surveillance program for pediatric infection/inflammation central nervous system (CNS).The was conducted at Charité Department Pediatrics Berlin,...
BACKGROUND: Metabolic syndrome (MetS) is a cluster of metabolic abnormalities that can affect civilian pilots’ health. Its prevalence and the correlation with periodontal disease (PD) among pilots had not been previously reported. The aim study was to determine MetS PD status, reveal their relationship in representative sample Chinese pilots. METHODS: We investigated 303 (mean age 34.92 ± 7.66 yr). General information as well blood saliva samples were collected. Diagnostic criteria for based...
The value of serum carbohydrate antigen 125 (CA125) combined with N-terminal pro-B-type natriuretic peptide (NT-proBNP) in the evaluation acute heart failure (AHF) after ST-segment elevation myocardial infarction (STEMI) remains unclear. aim this study was to evaluate efficacy CA125 NT-proBNP predicting AHF following STEMI. A total 233 patients STEMI were evaluated, including 39 Killip II-IV and 194 I. optimal cutoff point for determined by receiver operating characteristic (ROC) curve,...
Sacubitril/valsartan is an angiotensin receptor neprilysin antagonist (ARNI) approved for adult heart failure (HF). Its safety and efficacy in pediatric HF patients with cardiomyopathy or congenital disease are poorly understood. A pilot study was conducted to assess the clinical response, of sacubitril/valsartan this population at a tertiary care hospital China.Clinical parameters who received from January 2019 March 2023 were retrospectively collected analyzed. Children over 1 month left...
Enterovirus 71 (EV71), a member of Picornaviridae, causes severe neurological and systemic illness in children. To better understand the virus–host cell interactions, we performed triple-SILAC-based quantitative proteomics study monitoring host proteome changes after EV71 infection. Based on data for more than 4100 proteins, ∼17% proteins were found as significantly changed (p<0.01) at either 8 or 20 hours post Five biological processes seven protein classes showed significant differences....
Background Left atrial enlargement (LAE) is a common cardiac structural change in patients with hypertension, and obesity could further promote LAE. However, little known about the effect of overweight on left size, if there gender difference effect. The aim this study was to analyze effects different body mass index (BMI) grades (normal weight, overweight, obesity) size both male female hypertension.Methods A total 710 hypertension were divided into 3 groups: normal weight group (BMI < 24...
Abstract Background: A multi-analyte blood test has the potential to maximize performance for early detection across different cancer stages and types. Improvements in early-stage might be achieved using multi-component tests with high sensitivities specificities. We recently performed a large feasibility study assess of 4 biomarkers (aneuploidy, methylation, mutation, protein) cancers from up 15 organ sites. Specifically, training validation set was tested 3 subsequently confirmed an...
Cardiac troponin T (cTnT) is currently one of the important indicators for clinical diagnosis myocardial injury, which inevitable in cardiac surgery, especially coronary artery bypass grafting (CABG). Describing release profile cTnT and finding out risk factors postoperative injury (PMI) are great significance. The purposes this study to explore patients undergoing CABG search independent PMI.In retrospective study, data were collected. was measured at 24 hours before 6, 12, 24, 48, 72, 96...
Abstract Background: A multi-biomarker blood test has the potential to detect cancers in a broad range of organ types and stages. We previously trained independently assessed performance two biomarker classes (methylation protein; MP) for multi-cancer early detection (MCED) prospectively collected study (Cancer Res,2024;84(7Supp):LB100). Here, we addition somatic mutation reflex approach samples with initially negative MP-results (MP-reflex; MP-r). Methods: This included 3,160 (739 cancer...