A5081303920- Lipid metabolism and disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Liver Disease Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Physical Activity and Health
- Nutritional Studies and Diet
- Obesity, Physical Activity, Diet
- Cancer-related molecular mechanisms research
- Chronic Kidney Disease and Diabetes
- Diabetes Management and Research
- Blood Pressure and Hypertension Studies
- Diabetes Treatment and Management
- Adipose Tissue and Metabolism
- Regulation of Appetite and Obesity
- Retinal Diseases and Treatments
- Neurological Disease Mechanisms and Treatments
- Retinal Imaging and Analysis
- Apelin-related biomedical research
- Oral health in cancer treatment
- Diet, Metabolism, and Disease
- Birth, Development, and Health
- Growth Hormone and Insulin-like Growth Factors
- Adrenal Hormones and Disorders
- Mesenchymal stem cell research
- Nutrition and Health in Aging
Huazhong University of Science and Technology
2011-2024
Tongji Hospital
2011-2024
National Clinical Research Center for Digestive Diseases
2021-2024
Qinghai University
2022-2023
Qinghai University Affiliated Hospital
2023
Abstract Inhibition of immunocyte infiltration and activation has been suggested to effectively ameliorate nonalcoholic steatohepatitis (NASH). Paired immunoglobulin-like receptor B (PirB) its human ortholog receptor, leukocyte (LILRB2), are immune-inhibitory receptors. However, their role in NASH pathogenesis is still unclear. Here, we demonstrate that PirB/LILRB2 regulates the migration macrophages during by binding with ligand angiopoietin-like protein 8 (ANGPTL8). Hepatocyte-specific...
To investigate the relationship between metabolic score for insulin resistance (METS-IR) index and major adverse cardiac events (MACEs) to compare its ability predict MACEs with other IR indices including homeostatic model assessment (HOMA-IR) triglyceride glucose (TyG) index-related parameters.We conducted a cohort study enrolling 7,291 participants aged ≥40 years. Binary logistic regression restricted cubic splines were performed determine association METS-IR MACEs, receiver operating...
The aim of the research was to investigate factors contributing cognitive dysfunction in type 2 diabetic patients, distinguish complex relationship between retinopathy (DR) and different status.Two hundred ninety-seven diabetes mellitus (T2DM) patients were enrolled our study. We adopted Clinical Dementia Rating (CDR), Mini-mental State Examination (MMSE) Montreal Cognitive Assessment (MOCA) evaluate function. Firstly, cognition status classified into dementia non-dementia according MMSE...
Type 2 diabetes mellitus (T2D) is associated with an increased risk of cognitive dysfunction. Angiopoietin-like protein 8 (ANGPTL8) important regulator in T2D, but the role ANGPTL8 diabetes-associated dysfunction remains unknown. Here, we explored through its interaction paired immunoglobulin-like receptor B (PirB) central nervous system.
Bone marrow adipose tissue (MAT) has the potential to exert both local and systemic effects on metabolic homeostasis. As a first-line drug used treat type 2 diabetes mellitus, metformin conflicting MAT bone mesenchymal stem cell (BM-MSC) differentiation. Through series of experiments in vivo vitro, we found that except improving glucose lipid metabolism disorder ob/ob mice, 200 mg/kg increased mice tibia, prompted osteogenic genes (RunX2, OPN, OCN) lipogenic (Ppar-γ, Cebpα, Scd1) expression...
Angiopoietin-like protein 8 (ANGPTL8), an important regulator of lipid metabolism, is increased in diabetes and associated with insulin resistance. However, the role ANGPTL8 outcomes diabetic patients remains unclear. This study aimed to investigate circulating levels participants without its potential associations clinical a 5 year cohort study.Propensity-matched cohorts subjects from Risk Evaluation Cancers Chinese Diabetic Individuals: A longitudinal (REACTION) were generated on basis...
A novel classification has been introduced to promote precision medicine in diabetes. The current study aimed investigate the relationship between leptin and resistin levels with refined subgroups patients type 2 diabetes mellitus (T2DM).The k-means analysis was conducted cluster 541 T2DM into following four subgroups: mild obesity-related (MOD), severe insulin-deficient (SIDD), insulin-resistant (SIRD) age-related (MARD). Individuals meeting exclusion criteria were eliminated, data for 285...
Abstract ANGPTL8, an important regulator of glucose and lipid metabolism, is associated with diabetes, but the role ANGPTL8 in outcomes novel subgroups diabetes remains unclear. To assess circulating levels their association health outcomes, we performed a data-driven cluster analysis (k-means) patients newly diagnosed (741 enrolled from 2011 through 2016) Risk Evaluation Cancers Chinese Diabetic Individuals: longitudinal (REACTION) study. The primary were mortality all causes cardiovascular...
Background Previous studies showed altered angiopoietin-like protein-8 (ANGPTL-8) and resistin circulating levels in type 2 diabetes mellitus (T2DM). Whether or not the alteration ANGPTL-8 level can be a predictive maker for increased diabetic nephropathy risk remains unclear. Aim To Investigate possible association of with DN, whether this is affected by NAFLD status. Methods A total 278 T2DM patients were enrolled. Serum ANGPTL8, resistin, BMI, blood pressure, duration diabetes,...
ANGPTL8, an important regulator of lipid metabolism, was recently proven to have additional intracellular and receptor-mediated functions. This study aimed investigate circulating levels ANGPTL8 its potential association with the risk kidney function decline in a cohort study.We analysed 2,311 participants aged 40 years old older from China Cardiometabolic Disease Cancer Cohort (4C) Study. Kidney defined as estimated glomerular filtration rate (eGFR) less than 60 mL per minute 1.73 m2 body...
Angiopoietin-like protein 8 (ANGPTL8) is a secreted predominantly expressed in liver and adipose tissue. ANGPTL8 modulates the clearance of triglycerides (TGs) by suppressing activity lipoprotein lipase (LPL) within plasma. Previous studies found that circulating levels were significantly increased metabolic disorder-related diseases, such as type 2 diabetes mellitus (T2DM), obesity, syndrome nonalcoholic fatty disease (NAFLD). Whether has direct pathogenic role these diseases remains to be...
Background: Chronic kidney disease (CKD) is recognized as a major public health problem with high morbidity and mortality worldwide. Recently, angiopoietin-like protein 8 (ANGPTL8) was found to regulate lipid metabolism. Previous studies suggested that serum ANGPTL8 levels increased in patients diabetes, especially diabetic albuminuria. This study aimed investigate the association between circulating of function general population. Methods: The subjects were renal dysfunction [estimated...
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Background:Prior studies suggest that sedentary behavior is a well-known risk factor for cardiometabolic diseases.However, the longitudinal association between overall siting time and kidney function decline not known. Material/Methods:We performed nationwide prospective cohort study in individuals aged more than 40 years enrolled China Cardiometabolic Disease Cancer Cohort (4C) study.A total of 132 123 were included this study.Sitting was measured with short version International Physical...
s and Programme: EUROANAESTHESIA 2011: The European Anaesthesiology Congress: Intensive Care Medicine
Abstract Background: ANGPTL8, an important regulator of glucose and lipid metabolism, is increased in diabetes associated with insulin resistance. However, the role ANGPTL8 outcomes remains unclear. The study aimed to investigate circulating levels participants without its potential association death cardiovascular renal a 5-year cohort study. Methods: Propensity-matched cohorts subjects from Risk Evaluation Cancers Chinese Diabetic Individuals: A longitudinal (REACTION) was generated on...
Abstract Background: ANGPTL8, an important regulator of lipid metabolism, is increased in diabetes and associated with insulin resistance. However, the role ANGPTL8 outcomes diabetic patients remains unclear. This study aimed to investigate circulating levels participants without its potential associations clinical a 5-year cohort study. Methods: Propensity-matched cohorts subjects from Risk Evaluation Cancers Chinese Diabetic Individuals: A longitudinal (REACTION) were generated on basis...
To explore the clinical outcomes among preadmission insulin-treated type 2 diabetes mellitus (T2DM) in intensive care units (ICU).In this retrospective observational study, 578 T2DM patients admitted to ICU were recruited from March 2011 February 2021, which composed of 528 treated with insulin after admission (including 300 non-insulin-treated and 228 patients) 50 without before admission. Clinical compared between groups. Variables age (± 10 years), gender, blood glucose >10 mmol/l on...
Abstract Inhibition of immunocyte infiltration and activation has been proven to effectively ameliorate hepatic inflammation fibrosis in nonalcoholic steatohepatitis (NASH). Paired immunoglobulin-like receptor B (PirB) its human orthologue receptor, leukocyte (LILRB2), are immune-inhibitory receptors with unknown roles NASH. Here, we demonstrate that PirB/LILRB2 regulates the migration macrophages NASH pathogenesis fibrogenesis by binding NASH-associated ligand angiopoietin-like protein 8...