A5100699351- Diabetes Treatment and Management
- Nutrition and Health in Aging
- Metabolism, Diabetes, and Cancer
- Frailty in Older Adults
- Body Composition Measurement Techniques
- Diet and metabolism studies
- Dialysis and Renal Disease Management
- Adipose Tissue and Metabolism
- Inflammasome and immune disorders
- Pancreatic function and diabetes
- Gout, Hyperuricemia, Uric Acid
- Cancer-related molecular mechanisms research
- Diabetes Management and Research
- Liver Disease Diagnosis and Treatment
- Pharmacology and Obesity Treatment
- Lipid metabolism and disorders
- Mobile Health and mHealth Applications
- Metabolomics and Mass Spectrometry Studies
- Sphingolipid Metabolism and Signaling
- Blood Pressure and Hypertension Studies
- Clinical Nutrition and Gastroenterology
- Lipid Membrane Structure and Behavior
- Chronic Kidney Disease and Diabetes
- Peroxisome Proliferator-Activated Receptors
- Alcohol Consumption and Health Effects
West China Hospital of Sichuan University
2014-2024
Sichuan University
2014-2024
Huazhong University of Science and Technology
2014-2023
Tongji Hospital
2014-2023
National Clinical Research Center for Digestive Diseases
2021-2023
Ningbo University
2022
Jinan University
2011
Abstract Background The Jamar hydraulic dynamometer is a widely recognized tool for measuring grip strength. Nevertheless, the devices used most often in Asian countries are spring-type dynamometers, represented by CAMRY or Smedley dynamometer. We aimed to evaluate reliability and validity of compared with Methods This was cross-sectional study using random crossover design strength test two dynamometers. A total 1064 healthy community-dwelling older adults aged 50–90 years old, which...
Purpose: Higher serum levels of uric acid (SUA) are associated with an increased risk developing type 2 diabetes.Meanwhile, insulin resistance and beta-cell dysfunction critical factors that mediate the progression from normal glucose tolerance to impaired fasting (IFG) diabetes.We aimed investigate association between SUA in individuals without diabetes, thus explicating role early stage natural history diabetes.Patients Methods: We used cross-sectional data China Health Nutrition Survey...
Kawasaki disease (KD) can lead to permanent damage coronary structures, the pathogenesis of which remains unknown. This experiment was designed investigate whether miR-223-3p secreted in serum KD patients affects proliferation and apoptosis HCAECs by regulating FOXP3.
Abstract Background Quantitative assessment of muscle mass is a critical step in sarcopenia disease management. Expanding upon the use ultrasound foetal growth assessment, we established and validated an ultrasound-derived system for older adults at risk sarcopenia. Methods A total 669 were recruited three cohorts this cross-sectional study. In cohort 1(n = 103), most valuable sites skeletal index (SMI) estimation located among 11 scanning sites. An SMI estimating algorithm based on...
Selective S1P1 receptor agonists have therapeutic potential to treat a variety of immune-mediated diseases. A series 2-imino-thiazolidin-4-one derivatives displaying potent agonistic activity were selected establish 3D-QSAR models using CoMFA and CoMSIA methods. Internal external cross-validation techniques investigated as well some measures including region focusing, progressive scrambling, bootstraping leave-group-out. The satisfactory model predicted q2 value 0.751 an r2 0.973, indicating...
Background: Chronic kidney disease (CKD) is recognized as a major public health problem with high morbidity and mortality worldwide. Recently, angiopoietin-like protein 8 (ANGPTL8) was found to regulate lipid metabolism. Previous studies suggested that serum ANGPTL8 levels increased in patients diabetes, especially diabetic albuminuria. This study aimed investigate the association between circulating of function general population. Methods: The subjects were renal dysfunction [estimated...
Background:Prior studies suggest that sedentary behavior is a well-known risk factor for cardiometabolic diseases.However, the longitudinal association between overall siting time and kidney function decline not known. Material/Methods:We performed nationwide prospective cohort study in individuals aged more than 40 years enrolled China Cardiometabolic Disease Cancer Cohort (4C) study.A total of 132 123 were included this study.Sitting was measured with short version International Physical...
Abstract Inhibition of immunocyte infiltration and activation has been proven to effectively ameliorate hepatic inflammation fibrosis in nonalcoholic steatohepatitis (NASH). Paired immunoglobulin-like receptor B (PirB) its human orthologue receptor, leukocyte (LILRB2), are immune-inhibitory receptors with unknown roles NASH. Here, we demonstrate that PirB/LILRB2 regulates the migration macrophages NASH pathogenesis fibrogenesis by binding NASH-associated ligand angiopoietin-like protein 8...