A5001224228- Diabetes, Cardiovascular Risks, and Lipoproteins
- Liver Disease Diagnosis and Treatment
- Lipid metabolism and disorders
- Metabolism, Diabetes, and Cancer
- Peripheral Artery Disease Management
- Diet and metabolism studies
- Diabetes Treatment and Management
- Chronic Kidney Disease and Diabetes
- Birth, Development, and Health
- Cerebrovascular and Carotid Artery Diseases
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes Management and Research
- Endometriosis Research and Treatment
- Lipid metabolism and biosynthesis
- Diet, Metabolism, and Disease
- Mitochondrial Function and Pathology
- Lipoproteins and Cardiovascular Health
- Cancer, Lipids, and Metabolism
- Thyroid Disorders and Treatments
- Ovarian function and disorders
Tongji Hospital
2020-2025
Huazhong University of Science and Technology
2020-2025
National Clinical Research Center for Digestive Diseases
2021-2024
OBJECTIVE Peripheral artery disease (PAD) is a significant complication of type 2 diabetes (T2D), yet the association between plasma proteomics and PAD in people with T2D remains unclear. We aimed to explore relationship individuals T2D, assess whether could refine risk prediction. RESEARCH DESIGN AND METHODS This cohort study included 1,859 from UK Biobank. Multivariable-adjusted Cox regression models were used associations 2,920 proteins incident PAD. Proteins further selected as...
<p dir="ltr">Objective Peripheral artery disease (PAD) is a significant complication of type 2 diabetes (T2D), yet the association between plasma proteomics and PAD in people with T2D remains unclear. We aimed to explore relationship individuals T2D, assess whether could refine risk prediction. Research Design Methods This cohort study included 1859 from UK Biobank. Multivariable-adjusted Cox regression models were used associations 2920 proteins incident PAD. Proteins further selected...
To investigate the relationship between metabolic score for insulin resistance (METS-IR) index and major adverse cardiac events (MACEs) to compare its ability predict MACEs with other IR indices including homeostatic model assessment (HOMA-IR) triglyceride glucose (TyG) index-related parameters.We conducted a cohort study enrolling 7,291 participants aged ≥40 years. Binary logistic regression restricted cubic splines were performed determine association METS-IR MACEs, receiver operating...
Beige fat activation involves a fuel switch to fatty acid oxidation following chronic cold adaptation. Mitochondrial acyl-CoA synthetase long-chain family member 1 (ACSL1) localizes in the mitochondria and plays key role oxidation; however, regulatory mechanism of subcellular localization remains poorly understood. Here, we identify an endosomal trafficking component sortilin (encoded by Sort1) adipose tissues that shows dynamic expression during beige facilitates translocation ACSL1 from...
Angiopoietin-like protein 8 (ANGPTL8), an important regulator of lipid metabolism, is increased in diabetes and associated with insulin resistance. However, the role ANGPTL8 outcomes diabetic patients remains unclear. This study aimed to investigate circulating levels participants without its potential associations clinical a 5 year cohort study.Propensity-matched cohorts subjects from Risk Evaluation Cancers Chinese Diabetic Individuals: A longitudinal (REACTION) were generated on basis...
ANGPTL8, an important regulator of lipid metabolism, was recently proven to have additional intracellular and receptor-mediated functions. This study aimed investigate circulating levels ANGPTL8 its potential association with the risk kidney function decline in a cohort study.We analysed 2,311 participants aged 40 years old older from China Cardiometabolic Disease Cancer Cohort (4C) Study. Kidney defined as estimated glomerular filtration rate (eGFR) less than 60 mL per minute 1.73 m2 body...
Previous studies have been limited by their inability to differentiate between the effects of insulin sensitivity and β-cell function on risk kidney decline, cardiovascular disease (CVD), all-cause mortality. To address this knowledge gap, we aimed investigate whether physiological subtypes based homeostasis model assessment-2 (HOMA2) indices (HOMA2-B) (HOMA2-S) could be used identify individuals with subsequently high or low clinical outcome risk.
<p dir="ltr">Objective Peripheral artery disease (PAD) is a significant complication of type 2 diabetes (T2D), yet the association between plasma proteomics and PAD in people with T2D remains unclear. We aimed to explore relationship individuals T2D, assess whether could refine risk prediction. Research Design Methods This cohort study included 1859 from UK Biobank. Multivariable-adjusted Cox regression models were used associations 2920 proteins incident PAD. Proteins further selected...
<p dir="ltr">Objective Peripheral artery disease (PAD) is a significant complication of type 2 diabetes (T2D), yet the association between plasma proteomics and PAD in people with T2D remains unclear. We aimed to explore relationship individuals T2D, assess whether could refine risk prediction. Research Design Methods This cohort study included 1859 from UK Biobank. Multivariable-adjusted Cox regression models were used associations 2920 proteins incident PAD. Proteins further selected...
To investigate the associations between relative fat mass (RFM) and clinical outcomes in different glucose tolerance statuses modified effect of status. We analyzed 8,224 participants from a Chinese cohort study, who were classified into normal status (NGT), prediabetes, diabetes. Outcomes included fatal, nonfatal cardiovascular disease (CVD) events all-cause mortality. Associations RFM assessed using Cox regression. The was investigated mediation, interaction, joint analyses. During up to 5...
Background: Chronic kidney disease (CKD) is recognized as a major public health problem with high morbidity and mortality worldwide. Recently, angiopoietin-like protein 8 (ANGPTL8) was found to regulate lipid metabolism. Previous studies suggested that serum ANGPTL8 levels increased in patients diabetes, especially diabetic albuminuria. This study aimed investigate the association between circulating of function general population. Methods: The subjects were renal dysfunction [estimated...
<title>Abstract</title> Obesity and its related metabolic disorders are caused by an imbalance between homeostatic energy consumption expenditure. Brown beige adipose tissues have been shown to be protective against these diseases due their critical roles in non-shivering thermogenesis; additionally, adrenergic innervation of cells promotes lipolysis fatty acid oxidation<sup>1</sup>. A key enzyme promoting oxidation tissues, particularly response cold-stimulus, is mitochondrial acyl-CoA...
Abstract Background: ANGPTL8, an important regulator of glucose and lipid metabolism, is increased in diabetes associated with insulin resistance. However, the role ANGPTL8 outcomes remains unclear. The study aimed to investigate circulating levels participants without its potential association death cardiovascular renal a 5-year cohort study. Methods: Propensity-matched cohorts subjects from Risk Evaluation Cancers Chinese Diabetic Individuals: A longitudinal (REACTION) was generated on...
Abstract Background: ANGPTL8, an important regulator of lipid metabolism, is increased in diabetes and associated with insulin resistance. However, the role ANGPTL8 outcomes diabetic patients remains unclear. This study aimed to investigate circulating levels participants without its potential associations clinical a 5-year cohort study. Methods: Propensity-matched cohorts subjects from Risk Evaluation Cancers Chinese Diabetic Individuals: A longitudinal (REACTION) were generated on basis...