A5034702019- Multiple Myeloma Research and Treatments
- MicroRNA in disease regulation
- Cancer Treatment and Pharmacology
- Bone health and treatments
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- Circular RNAs in diseases
- Circadian rhythm and melatonin
- Hepatitis C virus research
- Effects and risks of endocrine disrupting chemicals
- Protein Degradation and Inhibitors
- Muscle Physiology and Disorders
- Aquaculture Nutrition and Growth
- Glycosylation and Glycoproteins Research
- Epigenetics and DNA Methylation
- Peptidase Inhibition and Analysis
- Animal Genetics and Reproduction
- Animal Nutrition and Physiology
- Cancer-related molecular mechanisms research
- Autophagy in Disease and Therapy
- Histone Deacetylase Inhibitors Research
- Neurobiology and Insect Physiology Research
- Monoclonal and Polyclonal Antibodies Research
- Sleep and Wakefulness Research
Hubei University of Chinese Medicine
2018-2025
First Affiliated Hospital of Jinan University
2024-2025
Hunan Normal University
2021-2024
University of Iowa
2023
Changsha University
2014-2022
Shanghai Advanced Research Institute
2022
Second Affiliated Hospital of Nanchang University
2022
Nanchang University
2022
State Key Laboratory of Chemobiosensing and Chemometrics
2018-2020
Jiangsu University of Science and Technology
2020
BackgroundBisphosphonates are the standard of care for reducing risk skeletal-related events in patients with bone lesions from multiple myeloma. The MRC Myeloma IX study was designed to compare effects zoledronic acid versus clodronic newly diagnosed Here, we report secondary outcomes relating skeletal events.MethodsPatients (≥18 years) myeloma were enrolled 120 centres UK and received intensive or non-intensive antimyeloma treatment. A computer-generated randomisation sequence used...
Attention-deficit/hyperactivity disorder (ADHD) is one of the most prevalent psychiatric disorders in children and adults. While ADHD patients often display circadian abnormalities, underlying mechanisms are unclear. Here we found that zebrafish mutant for gene period1b ( per1b ) displays hyperactive, impulsive-like, attention deficit-like behaviors low levels dopamine, reminiscent human patients. We clock directly regulates dopamine-related genes monoamine oxidase dopamine β hydroxylase ,...
This study was conducted to compare the presenting features and outcome of newly-diagnosed myeloma with without extramedullary (EM) manifestations determine optimum treatment. Seventy-five (16.3%) patients EM involvement at diagnosis were compared 384 cases disease. had a more favourable International Staging System different distribution isotypes. When adjusted according independent risk factors, in group treated chemotherapy alone significantly shorter overall survival (OS) those disease...
Secretory effector proteins expressed within the esophageal glands of root-knot nematodes (Meloidogyne spp.) are thought to play key roles in nematode invasion host roots and formation feeding sites necessary for complete their life cycle. In this study, a novel protein gene designated as Mj-nulg1a, which is specifically dorsal gland Meloidogyne javanica, was isolated through suppression subtractive hybridization. Southern blotting BLAST search analyses showed that Mj-nulg1a unique spp. A...
Summary Multiple myeloma ( MM ) is a heterogeneous disease. International Staging System/fluorescence hybridization ISS / FISH )‐based model and gene expression profiles GEP are effective approaches to define clinical outcome, although yet be improved. The discovery of class small non‐coding RNA s (micro s, mi s) has revealed new level biological complexity underlying the regulation expression. In this work, 163 presenting samples from patients were analysed by global profiling, distinct...
This study aimed to extract polysaccharides from pumpkin, characterize the structures of four them, and evaluate their in vitro antioxidant hypoglycemic activities. Additionally, an animal model type 2 diabetes mellitus (T2DM) was established used determine hypolipidemic effects vivo, underlying mechanisms related regulation gut microbiota. Water-extracted crude pumpkin (W-CPPs), water extraction alcohol precipitation (WA-CPPs), deproteinized (DPPs), refined (RPPs) were sequentially...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAntioxidative components of tanshen (Salvia miltiorhiza Bung)Ke Qin Zhang, Yongde Bao, Ping Wu, Robert T. Rosen, and Chi Tang HoCite this: J. Agric. Food Chem. 1990, 38, 5, 1194–1197Publication Date (Print):May 1, 1990Publication History Published online1 May 2002Published inissue 1 1990https://pubs.acs.org/doi/10.1021/jf00095a007https://doi.org/10.1021/jf00095a007research-articleACS PublicationsRequest reuse permissionsArticle...
To investigate the mechanism underlying regulatory effect of Met on broiler growth, growth performance, organ development, serum profile, myogenic gene expression, and methylation myostatin exon 1 region in response to dietary status were evaluated. A total 192 one-day-old Arbor Acres chicks housed 3-layer cages a temperature-controlled room with continuous lighting. The temperature was maintained at 32 34°C for first 3 d then reduced by 2 3°C per week final 20°C. Cages randomly allocated...
The present study aimed to investigate the responses of broilers with different hatching weights (HW) dietary methionine (Met). A total 192 1-d-old Arbor Acres broiler chicks HW (heavy: 48·3 ( sem 0·1) g and light: 41·7 g) were allocated a 2 × (Met) factorial arrangement six replicates eight chicks. Control starter (1–21 d) finisher (22–42 diets contained 0·50 0·43 % Met, respectively. Corresponding values for high-Met treatment 0·60 0·53 %. Light had poorer P < 0·05) growth performance...
Phthalates (PAEs) are endocrine-disrupting chemicals that widely present in everyday life and enter the human body through various pathways. The release of PAEs into environment pathways include leaching, evaporation, abrasion, use personal care products exposes humans to via ingestion, inhalation, dermal absorption. Pregnant women, as a particularly vulnerable population, risk adverse newborn growth development when exposed PAEs. While concentrations urine reflect recent exposure levels...
Abstract Spinal cord injury (SCI) impairs the central nervous system and induces myelin‐sheath‐deterioration because of reactive oxygen species (ROS), further hindering recovery function. Herein, simultaneously emergency treatment dynamic luminescence severity assessment (SETLSA) strategy is designed for SCI based on cerium (Ce)‐doped upconversion antioxidant nanoenzymes (Ce@UCNP‐BCH). Ce@UCNP‐BCH can not only efficiently eliminate localized ROS, but dynamically monitor oxidative state in...
The Magnesium Depletion Score (MDS) is a novel indicator that integrates multiple factors to assess systemic magnesium depletion. However, its association with hyperuricemia (HUA) prevalence remains unclear. This study aims investigate the relationship between MDS and of HUA. A cross-sectional analysis was conducted using data from 2007-2018 National Health Nutrition Examination Survey (NHANES). derived by integrating risk associated depletion: use diuretics proton pump inhibitors (PPI),...
Background The Lipid Accumulation Product (LAP), a novel indicator of fat accumulation, reflects the distribution and metabolic status body fat. This study aims to evaluate relationship between adult Americans’ prevalence osteoporosis LAP. Methods used data from NHANES cycles 2007–2010, 2013–2014, 2017–2018, including 4,200 adults aged 50 above. LAP was calculated using waist circumference triglyceride levels, whereas identified information dual-energy X-ray absorptiometry (DXA) assessments...