A5039921761- Chronic Lymphocytic Leukemia Research
- Monoclonal and Polyclonal Antibodies Research
- Chronic Myeloid Leukemia Treatments
- T-cell and B-cell Immunology
- Lymphoma Diagnosis and Treatment
- Mycotoxins in Agriculture and Food
- Immune Cell Function and Interaction
- Advanced biosensing and bioanalysis techniques
- Systemic Lupus Erythematosus Research
- Plant-Microbe Interactions and Immunity
- RNA and protein synthesis mechanisms
- Fungal and yeast genetics research
- Hepatitis B Virus Studies
- Cardiac electrophysiology and arrhythmias
- Peripheral Neuropathies and Disorders
- Traditional Chinese Medicine Analysis
- Traditional Chinese Medicine Studies
- Psoriasis: Treatment and Pathogenesis
- Plant Disease Resistance and Genetics
- Immunotherapy and Immune Responses
- Hepatitis C virus research
- Vitamin D Research Studies
- Toxin Mechanisms and Immunotoxins
- Ion channel regulation and function
- vaccines and immunoinformatics approaches
Anhui Normal University
2025
Zhejiang University
2007-2024
State Key Laboratory of Rice Biology
2020-2024
University of South China
2024
Wannan Medical College
2014-2024
First Affiliated Hospital of Wannan Medical College
2014-2024
Guizhou University
2024
Affiliated Hospital of Guizhou Medical University
2024
Hainan General Hospital
2020-2023
China National Rice Research Institute
2020-2023
Skin and mucous membranes come in contact with external environment protect tissues from infections by producing antimicrobial peptides. We report that human peptidoglycan recognition proteins 3 4 (PGLYRP3 PGLYRP4) are secreted as 89-115-kDa disulfide-linked homo- heterodimers bactericidal against several pathogenic nonpathogenic transient, but not normal flora, Gram-positive bacteria. PGLYRP3 PGLYRP4 also bacteriostatic toward all other tested bacteria, which include Gram-negative bacteria...
Acalabrutinib is a selective irreversible Bruton tyrosine kinase (BTK) inhibitor that does not affect IL2-associated or antibody-dependent cellular cytotoxicity, making it an attractive candidate for combination therapy with anti-CD20 antibodies. We investigated acalabrutinib plus obinutuzumab in phase Ib/II study (NCT02296918) of patients treatment-naïve relapsed/refractory chronic lymphocytic leukemia (CLL). Nineteen and 26 were treated (100 mg twice daily) until progression (cycle 1: 100...
Fusarium head blight (FHB) caused predominately by graminearum complex is a devastating disease of wheat. Frequent epidemics FHB have been reported in all FHB-prone regions during the last decade, especially China. not only causes loss grain yield, but also raises food safety risks due to harmful mycotoxin contamination infected grains. Deoxynivalenol (DON) most common and economically important identified cereal grains, it critical virulence factor for F. infection (Chen et al., 2019)....
Mycotoxin deoxynivalenol (DON) produced by the Fusarium graminearum complex is highly toxic to animal and human health. During DON synthesis, endoplasmic reticulum (ER) of F . intensively reorganized, from thin reticular structure thickened spherical crescent structure, which was referred as “DON toxisome”. However, underlying mechanism how ER reorganized into toxisome remains unknown. In this study, we discovered that overproduction ER-localized biosynthetic enzyme Tri4 or Tri1, intrinsic...
Colon cancer, a common type of malignant tumor, seriously endangers human health. However, due to the relatively slow progress in diagnosis and treatment, clinical therapeutic technology colon cancer has not been substantially improved past three decades. The present study was designed investigate effects involved mechanisms schisandrin B cell growth metastasis cancer. C57BL/6 mice received AOM dextran sulfate sodium. Mice treatment groups were gavaged with 3.75-30 mg/kg/day B. Transwell...
Fusarium graminearum produces the mycotoxin deoxynivalenol (DON) which promotes its expansion during infection on plant host wheat. Conditional expression of DON production is poorly characterized. Wheat defense compound putrescine, induces hypertranscription biosynthetic genes (FgTRIs) and subsequently leads to accumulation infection. Further, regulatory mechanisms FgTRIs upon putrescine treatment were investigated. The transcription factor FgAreA regulates putrescine-mediated by...
Increased intestinal barrier permeability, leaky gut, has been reported in patients with autism. However, its contribution to the development of autism not determined. We selected dextran sulfate sodium (DSS) disrupt and metformin repair BTBR T+tf/J autistic mice test this hypothesis. DSS treatment resulted a decreased affinity for social proximity; however, behaviors were improved after administration metformin. found an increased proximity/social memory repetitive anxiety-related...
Youkenafil is a novel oral selective PDE5 inhibitor for treating Erectile Dysfunction. This investigation assessed pharmacokinetics (PK), safety, and tolerability of youkenafil its main metabolite (M459) after taking 100 mg hydrochloride tablets in elderly young subjects. Phase I, single-center, open-label, parallel-group, single-dose study was conducted on 24 individuals (12 elders 12 youngsters). Each subject received single tablets. Blood samples were collected before medication up to 48...
Abstract A liquid chromatography–tandem mass spectrometry method with vonoprazan fumarate‐d4 as a stable isotope‐labeled internal standard was developed and validated aiming at quantification of fumarate in human plasma for bioequivalence study. Chromatographic separation achieved by acetonitrile one‐step protein precipitation using gradient elution 0.1% formic acid aqueous solution run time 3.65 min. Detection carried out on tandem spectrometer multiple reaction monitoring mode via positive...
The objective of the present study was to evaluate cardiovascular protective effects Danshensu, a water-soluble active component Danshen, in spontaneously hypertensive rats (SHR). SHR (male, 9 weeks old, n=30) were divided into three groups: 1) saline control (n=10); 2) Danshensu (10 mg/kg/d, intraperitoneally (i.p.)) treatment group and 3) Valsartan intragastrically (i.g.)) (n=10). Age-matched Wistar-Kyoto (n=10) used as normotensive controls. Saline drug treatments administered for 6...
The full set of T cell receptors (TCRs) in an individual is known as his or her TCR repertoire. Defining repertoires under physiological conditions and response to a disease vaccine may lead better understanding adaptive immunity thus has great biological clinical value. In the past decade, several high-throughput sequencing-based tools have been developed assign TCRs germline genes extract complementarity-determining region 3 (CDR3) sequences using different algorithms. Although these claim...
Antibody repertoire sequencing enables researchers to acquire millions of B cell receptors and investigate these molecules at the single-nucleotide level. This power resolution in studying humoral responses have led its wide applications. However, most studies were conducted with a limited number samples. Given extraordinary diversity, assessment key features large sample set is demanded. Thus, we collect systematically analyze 2,152 high-quality heavy-chain antibody repertoires. Our study...
Abstract Precursor messenger RNA (pre-mRNA) splicing is an essential and tightly regulated process in eukaryotic cells; however, the regulatory mechanisms for are not well understood. Here, we characterize a binding protein named FgRbp1 Fusarium graminearum , fungal pathogen of cereal crops worldwide. Deletion leads to reduced efficiency 47% F. intron-containing gene transcripts that involved various cellular processes including vegetative growth, development, virulence. The human ortholog...
Background Famitinib, the novel oral multitargeting tyrosine kinase inhibitor, was developed for treatment of patients with advanced solid cancer. This investigation assessed pharmacokinetic (PK) effects itraconazole, an officially recommended CYP3A4 strong on famitinib and its metabolite (SHR116637).
Abstract Background/purpose(s) The gut microbiota and its metabolites play crucial roles in pathogenesis of arthritis, highlighting as a promising avenue for modulating autoimmunity. However, the characterization virome arthritis patients, including osteoarthritis (OA) gouty (GA), requires further investigation. Methods We employed virus-like particle (VLP)-based metagenomic sequencing to analyze viral community 20 OA 26 GA 31 healthy controls, encompassing total 77 fecal samples. Results...
Background and Objectives . Hyperparathyroidism hyperphosphatemia contribute to the inflammatory effects in chronic hemodialysis (HD) patients. Interleukin-17-producing<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:msup><mml:mrow><mml:msub><mml:mrow><mml:mtext>CD</mml:mtext></mml:mrow><mml:mrow><mml:mn>4</mml:mn></mml:mrow></mml:msub></mml:mrow><mml:mrow><mml:mo>+</mml:mo></mml:mrow></mml:msup></mml:mrow></mml:math>effector memory T (Th17) cells CD4 + CD25...