A5061032925- Antibiotics Pharmacokinetics and Efficacy
- Pneumonia and Respiratory Infections
- Analytical Methods in Pharmaceuticals
- Helicobacter pylori-related gastroenterology studies
- Blood disorders and treatments
- Gastroesophageal reflux and treatments
- Microfluidic and Capillary Electrophoresis Applications
- Bacterial Identification and Susceptibility Testing
First Affiliated Hospital of Wannan Medical College
2024
Wannan Medical College
2023-2024
Abstract A liquid chromatography–tandem mass spectrometry method with vonoprazan fumarate‐d4 as a stable isotope‐labeled internal standard was developed and validated aiming at quantification of fumarate in human plasma for bioequivalence study. Chromatographic separation achieved by acetonitrile one‐step protein precipitation using gradient elution 0.1% formic acid aqueous solution run time 3.65 min. Detection carried out on tandem spectrometer multiple reaction monitoring mode via positive...
A steady, high-efficiency, and precise liquid chromatography-electrospray ionization-tandem mass spectrometry method was established validated using cefaclor-d5 as the stable isotope-labeled internal standard for quantification of cefaclor in human plasma. One-step protein precipitation applied to extract plasma samples methanol precipitant. An Ultimate XB C18 column (2.1 × 50.0 mm, 5.0 μm) used achieve chromatographic separation. Mobile phases gradient elution were an aqueous solution...
Abstract A liquid chromatography electrospray ionization tandem mass spectrometry method with amoxicillin‐d 4 as the stable isotope‐labeled internal standard for simultaneous quick detection of amoxicillin and clavulanic acid in human plasma was developed validated. Chromatographic separations were performed on a Hedera ODS‐2 column (2.1 × 150 mm, 5 μm). The mobile phases gradient elution aqueous solution containing 0.2% acetic (AA) (mobile phase A) together organic (acetonitrile methanol...