A5108467653- Gut microbiota and health
- Diet and metabolism studies
- Genomics and Phylogenetic Studies
- Microbial Community Ecology and Physiology
- Clostridium difficile and Clostridium perfringens research
- Reproductive tract infections research
- Dietary Effects on Health
- Nutritional Studies and Diet
- Neuroinflammation and Neurodegeneration Mechanisms
- Cell Image Analysis Techniques
- Advanced Fluorescence Microscopy Techniques
- Oral microbiology and periodontitis research
- Wheat and Barley Genetics and Pathology
- Urinary Tract Infections Management
- Traditional Chinese Medicine Studies
- Bacteriophages and microbial interactions
- Food composition and properties
- Pelvic floor disorders treatments
- Gastrointestinal motility and disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pediatric health and respiratory diseases
- Food Security and Health in Diverse Populations
- Metabolomics and Mass Spectrometry Studies
- Image Processing Techniques and Applications
- Probiotics and Fermented Foods
Zhujiang Hospital
2017-2025
Southern Medical University
2016-2025
Northwest A&F University
2021-2025
Columbia University Irving Medical Center
2024-2025
Southern Medical University Shenzhen Hospital
2025
Zhengzhou University of Light Industry
2025
Institute of Agro-Products Processing Science and Technology
2025
Chinese Academy of Agricultural Sciences
2023-2025
Institute of Food Science and Technology
2023-2025
Beihang University
2024
Sediment, a special realm in aquatic environments, has high microbial diversity. While there are numerous reports about the community marine sediment, freshwater and intertidal sediment communities have been overlooked. The present study determined millions of Illumina reads for comparison bacterial freshwater, wetland, sediments along Pearl River, China, using technically consistent approach. Our results show that both taxon richness evenness were highest medium lowest sediment. number...
Gut microbiota has been suggested to play a role in almost all major diseases including cardio- and cerebrovascular diseases. A possible mechanism is the transformation of dietary choline l-carnitine into trimethylamine by gut bacteria. This metabolite further oxidized trimethylamine-N-oxide (TMAO) liver promotes atherogenesis. Nevertheless, little known about microbial diversity blood TMAO levels stroke patients.We performed case-control study patients with large-artery atherosclerotic...
In the present report, we show that human fecal microbiota contains promising and universal biomarkers for noninvasive evaluation of inflammatory bowel disease severity IFX treatment efficacy, emphasizing potential ability to mine gut as a modality stratify IBD patients apply personalized therapy optimal outcomes.
Pre-eclampsia (PE) is one of the malignant metabolic diseases that complicate pregnancy. Gut dysbiosis has been identified for causing diseases, but role gut microbiome in pathogenesis PE remains unknown.We performed a case-control study to compare faecal and normotensive pregnant women by 16S ribosomal RNA (rRNA) sequencing. To address causative relationship between PE, we used microbiota transplantation (FMT) an antibiotic-treated mouse model. Finally, determined translocation immune...
We evaluated differences in the compositions of faecal microbiota between 52 end stage renal disease (ESRD) patients and 60 healthy controls southern China using quantitative real-time polymerase chain reaction (qPCR) high-throughput sequencing (16S ribosomal RNA V4-6 region) methods. The absolute quantification total bacteria was significantly reduced ESRD (p < 0.01). In three enterotypes, Prevotella enriched group whereas Bacteroides were prevalent (LDA score > 4.5). 11 bacterial taxa...
Abstract The gut microbiota has been implicated in glucose intolerance and its progression towards type-2 diabetes mellitus (T2DM). Relevant randomized clinical trial with prebiotic intervention was inadequate. We sought to evaluate the impact of fructooligosaccharides (FOS) galactooligosaccharides (GOS) on glycemia during oral tolerance test (OGTT) intestinal microbiota. A double-blind cross-over study performed 35 adults treated FOS GOS for 14 days (16 g/day). Faeces sampling, OGTT...
Chronic kidney disease (CKD) patients have an increased risk of cardiovascular diseases (CVDs). The present study aimed to investigate the gut microbiota and blood trimethylamine-N-oxide concentration (TMAO) in Chinese CKD explore underlying explanations through animal experiment. median plasma TMAO level was 30.33 μmol/L patients, which significantly higher than 2.08 measured healthy controls. Next-generation sequence revealed obvious dysbiosis microbiome with reduced bacterial diversity...
Stroke is a leading cause of death and disability worldwide. Neuroprotective approaches have failed in clinical trials, thus warranting therapeutic innovations with alternative targets. The gut microbiota an important contributor to many risk factors for stroke. However, the bidirectional interactions between stroke remain largely unknown.
Summary BACKGROUND Nucleic acid test and antibody assay have been employed in the diagnosis for SARS-CoV-2 infection, but use of viral antigen has not successfully developed. Theoretically, is specific marker virus precedes appearance within infected population. There a clear need detection rapid early diagnosis. METHODS We included cohort 239 participants with suspected infection from 7 centers study. measured nucleocapsid protein nasopharyngeal swab samples parallel nucleic test. was taken...
Background: Significant dysbiosis occurs in the gut microbiome of stroke patients. Condensing these broad, complex changes into one index would greatly facilitate clinical usage data. Here, we formulated a microbiota patients with acute ischemic based on their patterns and tested whether was correlated brain injury early outcome. Methods: A total 104 90 healthy individuals were recruited, microbiotas compared to model Stroke Dysbiosis Index (SDI), which representing stroke-associated...
Objective: Gut microbiota is a newly identified risk factor for stroke, and there are no large prospective studies linking the baseline gut microbiome to long-term of stroke. We present here correlation between stroke in people with prior history. Methods: A total 141 participants aged ≥60 years without history were recruited divided into low-risk, medium-risk high-risk groups based on known factors whether they suffering from chronic diseases. The composition their microbiomes was compared...
The intestinal microbiota and its metabolites have been reported to play an important role in stroke. Gut microbiota-originating short-chain fatty acids (SCFAs) modulate brain functions directly or indirectly through immune, endocrine, vagal, other humoral pathways. However, relatively few investigations evaluated the gut microbiome SCFAs spectrum their potential associations with stroke outcomes acute ischemic (AIS) patients different severities.We used 16S rRNA gene sequencing gas...
Intestinal dysbiosis is implicated in Systemic Lupus Erythematosus (SLE). However, the evidence of gut microbiome changes SLE limited, and association changed with activity SLE, as well its functional relevance still remains unknown. Here, we sequenced 16S rRNA amplicon on fecal samples from 40 patients (19 active patients, 21 remissive patients), 20 disease controls (Rheumatoid Arthritis (RA) 22 healthy (HCs), investigated categories taxonomic composition by Phylogenetic Investigation...
Non-alcoholic fatty liver disease (NAFLD) is regarded as a pandemic that affects about quarter of the global population. Recently, host-gut microbiota metabolic interactions have emerged distinct mechanistic pathways implicated in development NAFLD. Here, we report group gut microbiota-modified bile acids (BAs), hyodeoxycholic acid (HDCA) species, are negatively correlated with presence and severity HDCA treatment has been shown to alleviate NAFLD multiple mouse models by inhibiting...
Abstract Evidence from human cohorts indicates that chronic insomnia is associated with higher risk of cardiometabolic diseases (CMD), yet whether gut microbiota plays a role unclear. Here, in longitudinal cohort ( n = 1809), we find the microbiota-bile acid axis may link positive association between and CMD. Ruminococcaceae UCG-002 UCG-003 are main genera mediating These results also observed an independent cross-sectional 6122). The inverse associations those microbial biomarkers CMD...
Poststroke cognitive impairment (PSCI) is prevalent in stroke patients. The etiology of PSCI remains largely unknown. We previously found that induces gut microbiota dysbiosis which affects brain injury. Hereby, we aimed to investigate whether the contributes pathogenesis PSCI.83 patients were recruited and their function measured by Montreal Cognitive Assessment (MoCA) scores 3 months after onset. peripheral inflammatory factor levels compositions analyzed. Fecal transplantation from mice...