A5064975207- Immunotherapy and Immune Responses
- SARS-CoV-2 and COVID-19 Research
- Hepatitis B Virus Studies
- COVID-19 Clinical Research Studies
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Cancer Immunotherapy and Biomarkers
- Inflammasome and immune disorders
- Immunodeficiency and Autoimmune Disorders
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Animal Virus Infections Studies
- vaccines and immunoinformatics approaches
- Long-Term Effects of COVID-19
- Immune cells in cancer
- Heat shock proteins research
- Reproductive System and Pregnancy
- Microbial Metabolites in Food Biotechnology
- Galectins and Cancer Biology
- COVID-19 Impact on Reproduction
- Immune Response and Inflammation
- Blood disorders and treatments
- Immune responses and vaccinations
- Phagocytosis and Immune Regulation
- Bioactive natural compounds
Army Medical University
2015-2025
Dalian University
2024-2025
Dalian Medical University
2024-2025
Nanjing Agricultural University
2017-2023
Hunan University
2023
State Council of the People's Republic of China
2022
Qingdao Huanghai University
2022
Institute of Immunology
2005-2012
South China University of Technology
2011-2012
Karolinska Institutet
2010
BACKGROUND The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome 2 (SARS-CoV-2) has posed great threat to human health. T cells play a critical role in antiviral immunity but their numbers and functional state COVID-19 patients remain largely unclear. METHODS We retrospectively reviewed the counts serum cytokine concentration from data 522 with laboratory-confirmed 40 healthy controls. In addition, expression cell exhaustion markers were measured 14...
Abstract It is unclear whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can directly infect human kidney, thus leading to kidney injury (AKI). Here, we perform a retrospective analysis of clinical parameters from 85 patients with laboratory-confirmed disease 2019 (COVID-19); moreover, histopathology six additional COVID-19 post-mortem examinations was performed. We find that 27% (23/85) exhibited AKI. The elderly and cases comorbidities (hypertension heart failure) are...
Summary BACKGROUND The outbreak of a novel coronavirus (SARS-CoV-2, previously provisionally named 2019 or 2019-nCoV) since December in Wuhan, China, has become an emergency major international concern. Apart from the respiratory system, it is unclear whether SARS-CoV-2 can also directly infect other tissues such as kidney induce acute renal failure. METHODS We conducted retrospective analysis estimated glomerular filtration rate (eGFR) along with clinical parameters 85 patients...
Abstract While lymphocytopenia is a common characteristic of patients infected by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), mechanisms responsible for this depletion are unclear. Through careful inspection spleens and lymph nodes (LNs) from six cases with postmortem examinations, we observed that SARS-CoV-2 could directly infect secondary lymphoid organs to induce cell death. Immunohistochemistry demonstrated ACE2 (angiotensin-converting enzyme 2), potential...
Summary BACKGROUND Nucleic acid test and antibody assay have been employed in the diagnosis for SARS-CoV-2 infection, but use of viral antigen has not successfully developed. Theoretically, is specific marker virus precedes appearance within infected population. There a clear need detection rapid early diagnosis. METHODS We included cohort 239 participants with suspected infection from 7 centers study. measured nucleocapsid protein nasopharyngeal swab samples parallel nucleic test. was taken...
Summary BACKGROUND The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome 2 (SARS-CoV-2) has posed great threat to human health, which been declared a public health emergency international concern (PHEIC) the WHO. T cells play critical role in antiviral immunity but their numbers and functional state COVID-19 patients remain largely unclear. METHODS We retrospectively reviewed counts total cells, CD4 + , CD8 cell subsets, serum cytokine concentration...
From the point of better biocompatibility and sustainability, biobased shape memory polymers (SMPs) are highly desired. We used 1,3-propanediol, sebacic acid, itaconic which have been industrially produced via fermentation or extraction with large quantities as main raw materials for synthesis poly(propylene sebacate). Diethylene glycol was to tailor flexibility polyester. The resulted polyesters were found be promising SMPs excellent recovery fixity (near 100% independent thermomechanical...
Abstract Exacerbation of macrophage-mediated inflammation contributes to pathogenesis various inflammatory diseases, but the immunometabolic programs underlying regulation macrophage activation are unclear. Here we show that V-set immunoglobulin-domain-containing 4 (VSIG4), a B7 family-related protein is expressed by resting macrophages, inhibits in response lipopolysaccharide. Vsig4 −/− mice susceptible high-fat diet-caused obesity and murine hepatitis virus strain-3 (MHV-3)-induced...
Abstract Background Thymosin alpha 1 (Tα1) had been used in the treatment of viral infections as an immune response modifier for many years. However, clinical benefits and mechanism Tα1 COVID-19 patients are still unclear. Methods We retrospectively reviewed outcomes 76 severe cases admitted to 2 hospitals Wuhan, China, from December 2019 March 2020. The thymus output peripheral blood mononuclear cells was measured by T-cell receptor excision circles (TRECs). levels exhaustion markers...
VSIG4 controls inflammation through MS4A6D-mediated transcriptional inhibition of Nlrp3 and Il-1 β in macrophages.
While lymphocytopenia is a common characteristic of coronavirus disease 2019 (COVID-19), the mechanisms responsible for this lymphocyte depletion are unclear. Here, we retrospectively reviewed clinical and immunological data from 18 fatal COVID-19 cases, results showed that these patients had severe lymphocytopenia, together with high serum levels inflammatory cytokines (IL-6, IL-8 IL-10), elevation many other mediators in routine laboratory tests, including C-reactive protein, lactate...
Viral fulminant hepatitis (FH) is a severe disease with high mortality resulting from excessive inflammation in the infected liver. Clinical interventions have been inefficient due to lack of knowledge for inflammatory pathogenesis virus-infected We show that wild-type mice murine virus strain-3 (MHV-3), model viral FH, manifest and association significant elevation IL-1β expression serum Whereas, infection receptor-I deficient (IL-1R1-/-) or IL-1R antagonist (IL-1Ra) treated mice,...
Many encapsulated bacteria use capsules to cause invasive diseases. However, it remains largely unknown how the enhance bacterial virulence under in vivo infection conditions. Here we show that primarily target liver survival at onset of blood-borne infections. In a mouse sepsis model, enabled human pathogens Streptococcus pneumoniae and Escherichia coli circumvent recognition liver-resident macrophage Kupffer cells (KCs) capsular serotype-dependent manner. contrast effective capture...
iGB3/CD1d1 determines the severity of DSS-colitis through inhibiting Nlrp3 , Il1b and Il18 transcription in macrophages.
Chronic hepatitis B was characterized by fluctuant immune response to infected hepatocytes resulting in hepatic inflammation and virus persistence. Recently, Programmed Death-1 (PD-1) its ligand PD-L1 have been demonstrated play an essential role balancing antiviral immunity the livers of acute patients, significantly influencing disease outcome. PD-1 up-regulation peripheral T cells is associated with dysfunction chronic patients. However, effect PD-1/PD-L1 on damage infective status still...
Numerous evidences indicated that angiogenesis was a crucial step in the development of tumor, thus immunotherapy antiangiogenesis has been involved as potentially relevant candidate targets cancer immunotherapy. Recently, tumor endothelial marker 8 (TEM8) discovered to be dominantly expressed endothelium, which presented new strategy therapy. However, up date, related study TEM8 on is very few. In this study, we constructed xenogenic DNA vaccine encoding human carried by attenuated...
Boehmite (BM) nanoplatelets were adopted to compound with fully biobased poly(propylene sebacate) (PPSe) form the shape memory composites. The PPSe/BM composites kept excellent properties as previously reported PPSe. Compared neat PPSe, possess much higher mechanical above melting point and faster biodegradation rate, which was demonstrated via tensile test at elevated temperature in vitro degradation experiments phosphate buffer saline (PBS), respectively. obviously improved are attributed...
Androgens contribute to the involution process of aging thymus gland. However, molecular mechanisms behind this effect remain largely unknown. We have investigated influence testosterone on ectopic synthesis glucocorticoids (GCs) in thymocytes, an activity recently shown by us be important for homeostatic regulation these cells. Castration, which leads a strong increase tissue and function, was associated with reduced GC release from thymocytes caused down-regulated expression several...
The inhibitory receptor programmed death-1 (PD-1) has the capacity to maintain peripheral tolerance and limit immunopathological damage; however, its precise role in fulminant viral hepatitis (FH) yet be described. Here, we investigated functional mechanisms of PD-1 as related FH pathogenesis induced by murine virus strain-3 (MHV-3). High levels PD-1-positive CD4+, CD8+ T cells, NK cells macrophages were observed liver, spleen, lymph node thymus tissues following MHV-3 infection....
<h3>Objectives</h3> Fulminant viral hepatitis (FH) remains a serious clinical problem for which the underlying pathogenesis unclear. The B and T lymphocyte attenuator (BTLA) is an immunoglobulin-domain-containing protein that has capacity to maintain peripheral tolerance limit immunopathological damage during immune responses. However, its precise role in FH yet be investigated. <h3>Design</h3> BTLA-deficient (BTLA<sup>−/−</sup>) mice their wild-type littermates were infected with murine...