A5007031682- Elbow and Forearm Trauma Treatment
- Pituitary Gland Disorders and Treatments
- Orthopedic Surgery and Rehabilitation
- Streptococcal Infections and Treatments
- Orthopedic Infections and Treatments
- Glioma Diagnosis and Treatment
- Shoulder Injury and Treatment
- Bone fractures and treatments
- Hematological disorders and diagnostics
- Heme Oxygenase-1 and Carbon Monoxide
- Head and Neck Surgical Oncology
- Meningioma and schwannoma management
- Pelvic and Acetabular Injuries
- Growth Hormone and Insulin-like Growth Factors
- Gout, Hyperuricemia, Uric Acid
- Musculoskeletal synovial abnormalities and treatments
- Spinal Fractures and Fixation Techniques
- Radiomics and Machine Learning in Medical Imaging
- Case Reports on Hematomas
- Spinal Hematomas and Complications
- Paraquat toxicity studies and treatments
- Hip and Femur Fractures
- Adrenal and Paraganglionic Tumors
- Spine and Intervertebral Disc Pathology
- Intracerebral and Subarachnoid Hemorrhage Research
Shenzhen Children's Hospital
2020-2025
West China Hospital of Sichuan University
2010-2024
Sichuan University
2010-2024
Fudan University
2024
Fudan University Shanghai Cancer Center
2024
Weatherford College
2021
State Key Laboratory of Biotherapy
2015-2018
Southern Medical University
2017
East China University of Science and Technology
2012
Sichuan Cancer Hospital
2009
Chronic kidney disease (CKD) patients have an increased risk of cardiovascular diseases (CVDs). The present study aimed to investigate the gut microbiota and blood trimethylamine-N-oxide concentration (TMAO) in Chinese CKD explore underlying explanations through animal experiment. median plasma TMAO level was 30.33 μmol/L patients, which significantly higher than 2.08 measured healthy controls. Next-generation sequence revealed obvious dysbiosis microbiome with reduced bacterial diversity...
Abstract: Intraperitoneal chemotherapy was explored in clinical trials as a promising strategy to improve the therapeutic effects of chemotherapy. In this work, we developed biodegradable and injectable drug-delivery system by coencapsulation docetaxel (Doc) LL37 peptide polymeric nanoparticles (Doc+LL37 NPs) thermosensitive hydrogel for colorectal peritoneal carcinoma therapy. Firstly, polylactic acid (PLA)-Pluronic L35-PLA (PLA-L35-PLA) prepare Doc+LL37 NPs using water-in-oil-in-water...
Neuromuscular abnormality is the leading cause of disability in adults. Understanding complex interplay between muscle structure and function crucial for effective treatment rehabilitation. However, substantial deformation muscles during movement (up to 40%) poses challenges accurate assessment. To address this, we developed a wearable structural-functional sensing patch (WSFP) that enables synchronous analysis function. The WSFP incorporates soft, stretchable electrode array...
Abstract Combination chemotherapy is an important protocol in glioma therapy and honokiol shows synergistic anticancer effects with doxorubicin. In this paper, (HK) doxorubicin (Dox) co-loaded Methoxy poly(ethylene glycol)-poly(ε-caprolactone) (MPEG-PCL) nanoparticles were prepared a assembly method. The particle size (about 34 nm), morphology, X-ray Powder Diffraction (XRD), vitro release profile, cytotoxicity cell proliferation studied detail. results indicated that could be efficiently...
To analyze the causes, locations, associated injuries, and relevant factors of lower limb pelvic fractures in hospitalized children China to provide a theoretical basis for reducing incidence such fractures. A retrospective analysis with admitted 27 tertiary children's hospitals affiliated China's Futang Research Center Pediatric Development between December 1, 2015, 31, 2019, was conducted. Inpatient cases were analyzed following age groups: Infants (< 2 years), Preschool (2–5 School (6–11...
Toxicity to central nervous system tissues is the common side effects for radiotherapy of brain tumor. The radiation toxicity has been thought be related damage cerebral endothelium. However, because lacking a suitable high-resolution vivo model, cellular response capillaries remained unclear. Here, we present flk:eGFP transgenic zebrafish larvae as feasible model study capillary. We showed that, in living larvae, could induce acute capillary shrinkage and blood-flow obstruction, resulting...
Abstract Background The purpose of this study was to introduce the arthroscopic internal drainage with anterior-anteromedial approach for treatment popliteal cysts in children. To compare its clinical efficacy open surgery. Methods This a retrospective case–control 102 patients diagnosed from January 2018 February 2020 who received included 27 cases minimally invasive group (MI group) and 75 surgery (OS group). MI 21 males 6 females, age 6.71 ± 2.16 years adequately widen valve opening...
Abstract Background Fractures of hands and feet are common in children, but relevant epidemiological studies currently lacking. We aim to study the characteristics hand foot fractures growth plate injuries children provide a theoretical basis for their prevention, diagnosis, treatment. Methods retrospectively analyzed data with who were hospitalized at Shenzhen Children’s Hospital between July 2015 December 2020. Data on demographic characteristics, fracture site, treatment method, etiology...
Background: Craniopharyngioma is a benign tumor, but recurrences are common and prognosis poor. The pathologic mechanism underlying the high recurrence still unknown. Aims: We hypothesized that there hypoxic microenvironments within craniopharyngiomas hypoxia inducible factor-1 alpha (HIF-1α) its related genes largely expressed in recurrent craniopharyngiomas. Materials Methods: A total of 19 patients with have been identified. relative quantitative expressions HIF-1α, vascular endothelial...
Abstract Self‐management is important for patients suffering from cerebrovascular events after neurosurgical procedures. An increasing number of artificial intelligence (AI)‐assisted tools have been used in postoperative health management. ChatGPT a new trend dialog‐based chatbot that could be as supplemental tool seeking information. Responses version 3.5 and 4.0 toward 13 questions raised by experienced neurosurgeons were evaluated this exploratory study their consistency appropriateness...
The aim of this was to analyze the effect different treatment options on radial neck fractures in children and explore factors affecting prognosis fractures.The clinical data 131 with admitted our hospital from 2010 2018 were retrospectively analyzed, patients divided into 6 groups according methods [manual reduction Kirschner wires (K-wires) for internal fixation (group A); manual elastic stable intramedullary nails (ESINs) B); leverage K-wires C); ESINs D); K-wires/ESINs E); open F)]....