A5031006924- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Pharmacological Effects of Natural Compounds
- Helicobacter pylori-related gastroenterology studies
- Liver Disease Diagnosis and Treatment
- Immune Cell Function and Interaction
- Multiple Sclerosis Research Studies
- Gut microbiota and health
- Hormonal Regulation and Hypertension
- Blood Pressure and Hypertension Studies
- Ginseng Biological Effects and Applications
- Ocular Infections and Treatments
- Chromosomal and Genetic Variations
- Infectious Diseases and Mycology
- Vibrio bacteria research studies
- Systemic Lupus Erythematosus Research
- Synthesis and Biological Evaluation
- Bacteriophages and microbial interactions
- Cytokine Signaling Pathways and Interactions
- Diet and metabolism studies
- Diabetes and associated disorders
- Immunodeficiency and Autoimmune Disorders
- Antimicrobial Resistance in Staphylococcus
- Inflammatory Bowel Disease
- Bacterial Identification and Susceptibility Testing
University of Sassari
2016-2025
Azienda Ospedaliero Universitaria di Sassari
2021-2025
University of Udine
2015-2024
Ospedale di Monfalcone
2024
Shenzhen Children's Hospital
2024
University of L'Aquila
2023
Tehran University of Medical Sciences
2011-2021
Sapienza University of Rome
2021
Istituto Neurologico Mediterraneo
2021
Macquarie University
2021
Several factors have been proposed to explain the high death rate of coronavirus disease 2019 (COVID-19) outbreak, including hypertension and hypertension-related treatment with Renin Angiotensin System inhibitors. Also, age multimorbidity might be confounders. No sufficient data are available demonstrate their independent role. We designed a cross-sectional, observational, multicenter, nationwide survey in Italy verify whether renin-angiotensin system inhibitors related COVID-19 severe...
Abstract Background Eradication of Helicobacter pylori is an important objective in overcoming gastric diseases. Many regimens are currently available but none them could achieve 100% success eradication. Eugenol and cinnamaldehyde that commonly used various food preparations known to possess antimicrobial activity against a wide spectrum bacteria. Aim The present study was performed assess the vitro effects eugenol indigenous standard H. strains, their minimum inhibitory concentrations...
Objectives : Nonalcoholic fatty liver disease (NAFLD) is a major cause of liver-related morbidity and frequently associated with obesity metabolic syndrome. The recently discovered hormone adiponectin produced by adipose tissue, low plasma considered key factor in the development insulin resistance underlying Animal studies suggest that may protect against non-alcoholic steatohepatitis, but direct evidence humans lacking. We therefore conducted this study to assess relationship between...
Journal Article Antibacterial activity of ozonized sunflower oil (Oleozon) Get access L.A. Sechi, Sechi Dipartimento di Scienze Biomediche, Università degli studi Sassari, Italy Search for other works by this author on: Oxford Academic Google Scholar I. Lezcano, Lezcano Centro Nacional de Investigaciones Cientificas, Ciudad l'Habana, Cuba N. Nunez, Nunez M. Espim, Espim Duprè, Duprè A. Pinna, Pinna Istituto Oftalmologia, P. Molicotti, Molicotti G. Fadda, Fadda Microbiologia, Facoltà Medicina...
OBJECTIVES Sardinia is an island community of 1.6 million people. There are also about 3.5 sheep and one hundred thousand cattle in which Johne's disease Mycobacterium avium subspecies paratuberculosis infection endemic. The present study was designed to determine what proportion people attending for ileocolonoscopy with or without Crohn's were infected this pathogen. METHODS detected by IS900 PCR on DNA extracts fresh intestinal mucosal biopsies as well isolation culture using supplemented...
Enterococci are widely distributed in the environment; within human body, they normal commensals of oral cavity, gastrointestinal tract and vagina. In recent years, enterococci have become one most frequent causes acquired nosocomial infections worldwide. The molecular mechanism virulence these bacteria is still not completely understood. aims this work were to characterize phenotypically 47 isolates Enterococcus faecalis faecium collected Sardinia (Italy) by their abilities adhere different...
The recently discovered hormone resistin is linked to the development of insulin resistance, but direct evidence levels in humans with nonalcoholic fatty liver disease (NAFLD) lacking.We conducted this study assess relationship between serum and NAFLD. We measured biochemical, hormonal, histological correlates 28 NAFLD patients, 33 controls, 30 obese patients [body mass index (BMI), >30 kg/m2] without NAFLD.Resistin adiponectin expression were sc adipose tissue by quantitative RT-PCR....
Rationale: The optimal strategy for the diagnosis of latent tuberculosis infection is controversial. Adoption a two-step (tuberculin skin test [TST] followed by an IFN-γ release assay [IGRA], compared with IGRA alone), may be limited TST-mediated boosting subsequent responses. Assessment within-subject variability will aid in establishing thresholds conversions and reversions, interpretation serial testing results.Objectives: To determine short-term impact TST on results.Methods:...
Background The accurate diagnosis of TB in HIV-infected patients, particularly with advanced immunosuppression, is difficult. Recent studies indicate that a lipoarabinomannan (LAM) assay (Clearview-TB®-ELISA) may have some utility for the patients; however, precise subgroup benefit from this technology requires clarification. LAM sputum samples has, hitherto, not been evaluated. Methods was measured and urine obtained 500 consecutively recruited ambulant suspected TB, 2 primary care clinics...
Enterotoxigenic Bacteroides fragilis (ETBF) produces toxin (BFT), which is associated with acute diarrheal, inflammatory bowel disease, and colorectal cancer (CRC). In experimental models, ETBF has been shown to contribute colon carcinogenesis. The present study was conducted investigate mucosal colonization of in the find a possible association between presence precancerous cancerous lesions. biopsies involved sites were obtained from 68 patients lesions 52 healthy controls (HC). samples...
Unilateral primary aldosteronism is the most common surgically correctable form of endocrine hypertension and usually differentiated from bilateral forms by adrenal venous sampling (AVS) or computed tomography (CT). Our objective was to compare clinical biochemical postsurgical outcomes patients with unilateral diagnosed CT AVS identify predictors surgical outcomes. Patient data were obtained 18 internationally distributed centers retrospectively analyzed for adrenalectomy management based...
Parkinson's disease is a neurodegenerative disorder and its etiology unknown, numerous studies show how different environmental factors can influence the development of disease. miRNAs are involved in several pathologies their dysregulation contribute to pathologies, also such as disease, Alzheimer's Huntington's Amyotrophic lateral sclerosis. In this study, we profiled expression candidate miRNAs: miR-155, miR-26a, miR-146a, miR132, PBMCs L-dopa treated Parkinson patients unaffected...
On March 24 and 25, 2017 researchers clinicians from around the world met at Temple University in Philadelphia to discuss current knowledge of Mycobacterium avium ssp. Paratuberculosis (MAP) its relationship human disease. The conference was held because shared concern that MAP is a zoonotic bacterium poses threat not only animal health but also health. In order further study this problem, conferees discussed ways improve diagnostic tests potential future anti-MAP clinical trials....
TAR DNA-binding protein 43 (TDP-43) proteinopathy in brain cells is the hallmark of amyotrophic lateral sclerosis (ALS) but its cause remains elusive. Asparaginase-like-1 (ASRGL1) cleaves isoaspartates, which alter folding and susceptibility to proteolysis. ASRGL1 gene harbors a copy human endogenous retrovirus HML-2, whose overexpression contributes ALS pathogenesis. Here we show that expression was diminished samples by RNA sequencing, immunohistochemistry, western blotting. TDP-43...
The envelope proteins syncytin-1 and pHERV-W from the Human Endogenous Retroviral family 'W' (HERV-W) have been identified as potential risk factors in multiple sclerosis (MS). This study aims to evaluate both humoral cell-mediated immune response antigenic peptides derived these across different clinical forms inflammatory phases of MS. Indirect enzyme-linked immunosorbent assay (ELISA) was employed measure immunoglobulin G (IgG) responses syncytin-1env 486-500 pHERV-Wenv 486-504 MS...
Human endogenous retroviruses (HERVs) constitute about 8% of the human genome. The overexpression HERVs has been detected in various inflammatory disorders like neuro-inflammation and cancer. Interestingly, it reported that stress conditions facilitate HERV expression. Space travel exposes astronauts to microgravity environments (a condition), which may result activation might influence pathogenic outcomes during after space flight. This study aimed elucidate transcriptional activity three...