A5024315850- Cancer, Hypoxia, and Metabolism
- Glioma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Adrenal and Paraganglionic Tumors
- Cancer Immunotherapy and Biomarkers
- Cancer Research and Treatments
- CAR-T cell therapy research
- Cancer-related Molecular Pathways
- Neuroblastoma Research and Treatments
- Immune cells in cancer
- RNA Interference and Gene Delivery
- Pituitary Gland Disorders and Treatments
- Mesenchymal stem cell research
- RNA modifications and cancer
- Advanced battery technologies research
- Microtubule and mitosis dynamics
- Ubiquitin and proteasome pathways
- Epigenetics and DNA Methylation
- CO2 Reduction Techniques and Catalysts
- DNA Repair Mechanisms
- Cancer therapeutics and mechanisms
- Urological Disorders and Treatments
- CRISPR and Genetic Engineering
- Renal and related cancers
- Electrocatalysts for Energy Conversion
National Institutes of Health
2016-2025
National Cancer Institute
2017-2025
Center for Cancer Research
2017-2025
Beijing VDJBio (China)
2025
Zhangzhou Normal University
2024
National Cancer Institute
2024
Nanjing University of Science and Technology
2022-2024
Jilin University
2024
National Center for Biotechnology Information
2022
St. John's University
2017-2021
Acidic CO2-to-HCOOH electrolysis represents a sustainable route for value-added CO2 transformations. However, competing hydrogen evolution reaction (HER) in acid remains great challenge selective production, especially industrial-level current densities. Main group metal sulfides derived S-doped metals have demonstrated enhanced selectivity alkaline and neutral media by suppressing HER tuning reduction intermediates. Yet stabilizing these sulfur dopants on surfaces at large reductive...
TAR DNA-binding protein 43 (TDP-43) proteinopathy in brain cells is the hallmark of amyotrophic lateral sclerosis (ALS) but its cause remains elusive. Asparaginase-like-1 (ASRGL1) cleaves isoaspartates, which alter folding and susceptibility to proteolysis. ASRGL1 gene harbors a copy human endogenous retrovirus HML-2, whose overexpression contributes ALS pathogenesis. Here we show that expression was diminished samples by RNA sequencing, immunohistochemistry, western blotting. TDP-43...
Abstract Mounting evidence suggests that inhibition of protein phosphatase-2A (PP2A), a serine/threonine phosphatase, could enhance anticancer immunity. However, drugs targeting PP2A are not currently available. Here, we report inhibitor, LB-100, when combined with anti-PD-1 (aPD-1) blockade can synergistically elicit durable immune-mediated antitumor response in murine CT26 colon cancer model. This effect is T-cell dependent, leading to regression significant proportion tumors. Analysis...
// Chao Zhang 1,2,* , Chunzhang Yang 3,* Michael J. Feldman 4 Herui Wang Ying Pang 2 Dominic M. Maggio Dongwang Zhu Cody L. Nesvick Pauline Dmitriev Petra Bullova 2,5 Prashant Chittiboina Roscoe O. Brady Karel Pacak and Zhengping Zhuang 1 Department of Orthopedics, Xinqiao Hospital, The Third Military Medical University, Chongqing, China Program in Reproductive Adult Endocrinology, Eunice Kennedy Shriver National Institute Child Health Human Development, Bethesda, Maryland, USA 3...
Glioblastoma survival remains unchanged despite continuing therapeutic innovation. Herein, we aim to (i) develop chimeric antigen receptor (CAR) T cells with a specificity unique antigen, carbonic anhydrase IX (CAIX), which is expressed in the hypoxic microenvironment characteristic of glioblastoma, and (ii) demonstrate its efficacy limited off-target effects.First demonstrated expression CAIX patient-derived glioblastoma samples available databases. CAR were generated against was assessed 4...
Cisplatin is currently used to treat inoperable recurrent meningiomas, but its side effects and drug resistance limit use. Metformin has recently been identified as a chemosensitizing agent. However, the combined treatment of cisplatin metformin in high-grade meningiomas not reported. Herein, our findings demonstrate significantly enhanced cisplatin-induced inhibition proliferation meningioma cells, which was associated with induction G0/G1 cell cycle arrest. Additionally, activated...
Abstract Despite strides in immunotherapy, glioblastoma multiforme (GBM) remains challenging due to low inherent immunogenicity and suppressive tumor microenvironment. Converting “cold” GBMs “hot” is crucial for immune activation improved outcomes. This study comprehensively characterized a therapeutic vaccination strategy preclinical GBM models. The vaccine consists of Mannan‐BAM‐anchored irradiated whole cells, Toll‐like receptor ligands [lipoteichoic acid (LTA), polyinosinic‐polycytidylic...
Abstract Purpose: Glioblastoma (GBM) is highly resistant to treatment, largely due disease heterogeneity and resistance mechanisms. We sought investigate a promising drug that can inhibit multiple aspects of cancer cell survival mechanisms become an effective therapeutic for GBM patients. Experimental Design: To TG02, agent with known penetration the blood–brain barrier, we examined effects as single in combination temozolomide, commonly used chemotherapy GBM. human cells syngeneic mouse...
Chimeric antigen receptor (CAR)-engineered T cells represent a promising modality for treating glioblastoma. Recently, we demonstrated that CAR-T targeting carbonic anhydrase IX (CAIX), protein involved in HIF-1a hypoxic signaling, is cell target an intracranial murine glioblastoma model. Anti-CAIX therapy limited by its suboptimal activation within the tumor microenvironment. LB-100, small molecular inhibitor of phosphatase 2A (PP2A), has been shown to enhance anti-tumor activity through...
Compared to normal cells, cancer cells exhibit a higher level of oxidative stress, which primes key cellular and metabolic pathways thereby increases their resilience under stress. This stress also can be exploited kill tumor while leaving intact. In this study we have found that isovalerylspiramycin I (ISP I), novel macrolide antibiotic, suppresses cell growth metastases by targeting the nucleolar protein selenoprotein H (SELH), plays critical roles in keeping redox homeostasis genome...
// Ying Pang 1 , Chunzhang Yang 2 Jan Schovanek 3 Herui Wang 4 Petra Bullova 5 Veronika Caisova Garima Gupta Katherine I. Wolf Gregg L. Semenza 6 Zhengping Zhuang and Karel Pacak Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health Human Development, Institutes Health, Bethesda, Maryland, USA Neuro-Oncology Branch, Center for Cancer Research, Institute, Department Internal Medicine III-Nephrology, Rheumatology, Endocrinology, Faculty Dentistry,...
Rheumatoid arthritis (RA) is a systemic, chronic inflammatory disease characterized by altered levels of cytokines. One the key cytokines involved in pathogenesis RA tumor necrosis factor α (TNF-α), which plays crucial role differentiation T cells and B serves as primary trigger inflammation joint damage RA. Human umbilical cord-derived mesenchymal stem (hUC-MSCs) have shown potential alleviating symptoms Previous vitro studies indicate that TNF-α secreted can activate NF-κB human MSCs,...
We previously identified a novel syndrome in patients characterized by paraganglioma, somatostatinoma, and polycythemia. In these patients, polycythemia occurs long before any tumor develops, removal only partially corrects polycythemia, with recurrence occurring shortly after surgery. Genetic mosaicism of gain-of-function mutations the EPAS1 gene (encoding HIF2α) located oxygen degradation domain (ODD), typically p.530–532, was shown as etiology this syndrome. The aim present investigation...
A flow-type reversible aqueous Zn–CO 2 battery using a Pd/SnO @C cathode catalyst has been assembled and demonstrates an ultra-high power density.
Abstract Background Head and neck paragangliomas (HNPGLs) are typically slow-growing, hormonally inactive tumors of parasympathetic paraganglia. Inactivation prolyl-hydroxylase domain-containing 2 protein causing indirect gain-of-function hypoxia-inducible factor-2α (HIF-2α), encoded by EPAS1, was recently shown to cause carotid body hyperplasia. We previously described a syndrome with multiple sympathetic caused direct variants in EPAS1 (Pacak-Zhuang syndrome, PZS) developed corresponding...
Metastatic cancer poses significant clinical challenges, necessitating effective immunotherapies with minimal systemic toxicity. Building on prior research demonstrating the rWTC-MBTA vaccine’s ability to inhibit tumor metastasis and growth, this study focuses its translation by optimizing vaccine composition, dosing regimens, freezing techniques. The formula components included three TLR ligands (LTA, Poly I:C, Resiquimod) an anti-CD40 antibody, which were tested in melanoma triple-negative...
Glioblastoma (GBM) is one of the most lethal adult brain tumors with limited effective therapeutic options. Immunotherapy targeting B7-H3 (CD276) has shown promising efficacy in treatment gliomas. However, response to this varies among glioma patients due individual differences. It's necessary find an strategy improve immunotherapy for non-responders. In study, we demonstrated a strong correlation between aurora kinase A (AURKA) and CD276 expression tissue samples. Additionally, both AURKA...
ETV6::RUNX1, the most common oncogenic fusion in pediatric B cell precursor acute lymphoblastic leukemia (BCP-ALL), induces a clinically silent preleukemic state that can persist carriers for over decade and may progress to overt upon acquisition of secondary lesions. The mechanisms contributing quiescence ETV6::RUNX1+ cells still remain elusive. In this study, we identify linker histone H1-0 as critical mediator by employing human -induced pluripotent stem (hiPSC) models engineered using...