A5076270318- Cancer, Hypoxia, and Metabolism
- Glioma Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Spectroscopy Techniques in Biomedical and Chemical Research
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- IoT-based Smart Home Systems
- RNA modifications and cancer
- Cancer Research and Treatments
- Brain Tumor Detection and Classification
- Sphingolipid Metabolism and Signaling
- Neuroblastoma Research and Treatments
- Smart Grid Energy Management
- Advancements in PLL and VCO Technologies
- Sensor Technology and Measurement Systems
- Conducting polymers and applications
- ATP Synthase and ATPases Research
- Caveolin-1 and cellular processes
- Experimental Learning in Engineering
- Advanced Battery Materials and Technologies
- Mesoporous Materials and Catalysis
- Folate and B Vitamins Research
- Advanced MEMS and NEMS Technologies
- Epigenetics and DNA Methylation
National Institutes of Health
2017-2024
National Cancer Institute
2017-2024
Center for Cancer Research
2017-2022
Center of Technology and Engineering for Nuclear Projects
2015-2020
Universitatea Națională de Știință și Tehnologie Politehnica București
2015-2018
University of Bucharest
2017-2018
University of Pitesti
2016-2018
Florida State University
2006-2017
Toyota Research Institute
2015
Ann Arbor Center for Independent Living
2015
The Boudouard reaction, which is the reaction of carbon and dioxide to produce monoxide, represents a simple straightforward method for remediation in environment through reduction: CO2(g) + C(s) ⇌ 2CO. However, due large positive enthalpy, typically reported be 172 kJ/mol under standard conditions at 298 K, equilibrium does not favor CO production until temperatures >700 °C, when entropic term, −TΔS, begins dominate free energy becomes negative. We have found that, microwave irradiation...
Eu(III)-doped Y(2)O(3) nanocrystals are prepared by microwave synthetic methods as spherical 6.4 ± 1.5 nm with a cubic crystal structure. The surface of the nanocrystal is passivated acetylacetonate (acac) and HDA on Y exposed facet nanocrystal. presence acac gives rise to strong S(0) → S(1) (π π*, acac) Ln(3+) ligand metal charge transfer (LMCT) transitions at 270 370 nm, respectively, in Eu:Y(2)O(3) Excitation into π*) or LMCT transition leads production white light emission arising from...
Altered cellular metabolism, including an increased dependence on aerobic glycolysis, is a hallmark of cancer. Despite the fact that this observation was first made nearly century ago, effective therapeutic targeting glycolysis in cancer has remained elusive. One potentially promising approach involves glycolytic enzyme lactate dehydrogenase (LDH), which overexpressed and plays critical role several cancers. Here, we used novel class LDH inhibitors to demonstrate, for time, Ewing sarcoma...
Abstract Background Osteosarcoma (OS) is a malignant bone tumor that often develops during the period of rapid growth associated with adolescence. Despite successful primary control accompanied by adjuvant chemotherapy, death from pulmonary metastases occurs in approximately 30% patients within 5 years. As overall survival remains unchanged over last 30 years, urgent needs for novel therapeutic strategies exist. Cancer metastasis characterized complex molecular events which result...
Infiltrating gliomas are devastating and incurable tumors. Amongst all gliomas, those harboring a mutation in isocitrate dehydrogenase 1 (IDH1
The detailed mechanism by which ethylene polymerization is initiated the inorganic Phillips catalyst (Cr/SiO2) without recourse to an alkylating cocatalyst remains one of great unsolved mysteries heterogeneous catalysis. Generation active starts with reduction CrVI ions dispersed on silica. A lower oxidation state, generally accepted be CrII, required activate form organoCr site. In this work, a mesoporous, optically transparent monolith CrVI/SiO2 was prepared using sol–gel chemistry in...
It is desirable that a thin film lithium–electrolyte interface flexible and self-healing to accommodate the large volume expansion during lithium deposition without rupturing impede electrolyte decomposition.
The anatomy of a truffle inspired sulfur particle for battery cathode.
Abstract Purpose: Glioblastoma (GBM) is highly resistant to treatment, largely due disease heterogeneity and resistance mechanisms. We sought investigate a promising drug that can inhibit multiple aspects of cancer cell survival mechanisms become an effective therapeutic for GBM patients. Experimental Design: To TG02, agent with known penetration the blood–brain barrier, we examined effects as single in combination temozolomide, commonly used chemotherapy GBM. human cells syngeneic mouse...
Stable, bright-white-light-emitting phosphor is fabricated from 5.5-nm CdSe quantum dots that are incorporated into a silica gel and calcined at 500 °C under air. Excited by UV radiation, the emitted light has almost pure white-light coordinates of (0.34, 0.36) on CIE (Commission internationale de l'éclairage) chromaticity chart Scotopic/Photopic ratio 2.56. Detailed facts importance to specialist readers published as "Supporting Information". Such documents peer-reviewed, but not...
Abstract Background Early detection of increased aggressiveness brain tumors is a major challenge in the field neuro-oncology because inability traditional imaging to uncover it. Isocitrate dehydrogenase (IDH)-mutant gliomas represent an ideal model system study molecular mechanisms associated with tumorigenicity they appear indolent and non-glycolytic initially, but eventually subset progresses toward secondary glioblastoma Warburg-like phenotype. The features this transformation are poorly...
The structure and mechanism of the formation sites which initiate ethylene polymerization in atomically dispersed Phillips catalyst (Cr/SiO2) are two great unsolved mysteries heterogeneous catalysis. After CO or C2H4 reduction silica-supported CrVI ions to CrII precatalyst, exposure results organoCrIII that capable initiating without recourse an external alkylating cocatalyst. In this work, a prepared, via sol–gel chemistry, as mesoporous, optically transparent monolith was reduced with...
The steam–carbon reaction, which is the essential reaction of gasification processes carbon-based feed stocks (e.g., coal and biomass), produces synthesis gas (H2 + CO), a synthetically flexible, environmentally benign energy source. very endothermic, mandates high temperatures large expenditure to drive reaction. We have found that using microwave irradiation selectively heat carbon leads dramatically different observed thermodynamics for From measurement equilibrium constants as function...
Chromium(VI) sites homogeneously dispersed in a transparent silica xerogel matrix have been investigated to determine the coordination environment and rationalize Raman spectra. X-ray absorption fine structure (EXAFS) analysis gives that is consistent with Cr containing two terminal oxygens bound by Cr−O−Si linkages. The was refined an R factor of 1.28%. CrO bonds were found bond length 1.60 Å bridging Cr−O 1.80 Å. spectrum, collected 785 nm excitation above edge chromium, shows strong band...
Detailed studies of lipids in biological systems, including their role cellular structure, metabolism, and disease development, comprise an increasingly prominent discipline called lipidomics. However, the conventional lipidomics tools, such as mass spectrometry, cannot investigate lipidomes until they are extracted, thus be used for probing lipid distribution nor studying live cells. Furthermore, techniques rely on extraction from relatively large samples, which averages data across...
In addition to providing integrity cellular structure, the various classes of lipids participate in a multitude functions including secondary messengers, receptor stimulation, lymphocyte trafficking, inflammation, angiogenesis, cell migration, proliferation, necrosis and apoptosis, thus highlighting importance understanding their role tumor phenotype. context IDH1
Abstract BACKGROUND Formalin-fixed, paraffin-embedded (FFPE) tissue slides are routinely used in cancer diagnosis, clinical decision-making, and stored biobanks, but their utilization Raman spectroscopy-based studies has been limited due to the background coming from embedding media. METHODS Spontaneous spectroscopy was for molecular fingerprinting of FFPE 46 patient samples with known methylation subtypes. Spectra were construct tumor/non-tumor, IDH1WT/IDH1mut, methylation-subtype...
Isocitrate dehydrogenase 1 (IDH1) mutations in gliomas, fibrosarcoma, and other cancers leads to a novel metabolite, D-2-hydroxyglutarate, which is proposed cause tumorigenesis. The production of this metabolite also causes vulnerabilities cellular metabolism, such as lowering NADPH levels. To exploit vulnerability, we treated glioma fibrosarcoma cells that harbor an IDH1 mutation with inhibitor nicotinamide adenine dinucleotide (NAD⁺) salvage pathway, FK866, observed decreased viability...
Membranes are of interest for a wide variety applications such as gas separation, water desalination, fuel cells and batteries. Because the flux across membrane scales inversely with thickness, thick is required to achieve high selectivity, at expense permeability. New ultrathin membranes which promise offer selectivity permeability highly desirable. Elemental sulfur can provide five times higher capacity than existing Li-ion cathode materials based on transition metal oxides or phosphates....
Standard therapy for chordoma consists of surgical resection followed by high-dose irradiation. Protein phosphatase 2A (PP2A) is a ubiquitously expressed serine/threonine involved in signal transduction, cell cycle progression, differentiation, and DNA repair. LB100 small-molecule inhibitor PP2A designed to sensitize cancer cells damage from irradiation chemotherapy. A recently completed phase I trial solid tumors demonstrated its safety. Here, we show the therapeutic potential...
Abstract Background Targeting glutamine metabolism in cancer has become an increasingly vibrant area of research. Mutant IDH1 (IDH1 mut ) gliomas are considered good candidates for targeting this pathway because the contribution to their newly acquired function: synthesis 2-hydroxyglutarate (2HG). Methods We have employed a combination 13 C tracers including and glucose investigating patient-derived glioma cell lines through NMR LC/MS. Additionally, genetic loss-of-function (in vitro vivo)...
Research in fundamental cell biology and pathology could be revolutionized by developing the capacity for quantitative molecular analysis of subcellular structures. To that end, we introduce Ramanomics platform, based on confocal Raman microspectrometry coupled to a biomolecular component algorithm, which together enable us molecularly profile single organelles live-cell environment. This emerging omics approach categorizes entire makeup sample into about dozen general classes subclasses...
Nutritional intervention is becoming more prevalent as adjuvant therapy for many cancers in view of the tumor dependence on external sources some nutrients. However, little known about mechanisms that make cancer cells require certain nutrients from microenvironment. Herein, we report glioma exogenous cysteine/cystine, despite this amino acid being nonessential. Using several 13 C‐tracers and analysis cystathionine synthase cystathioninase levels, revealed were not able to support...