A5009542155- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Parathyroid Disorders and Treatments
- Blood Pressure and Hypertension Studies
- Central Venous Catheters and Hemodialysis
- Health Systems, Economic Evaluations, Quality of Life
- Muscle and Compartmental Disorders
- Nutrition and Health in Aging
- Iron Metabolism and Disorders
- Renal Diseases and Glomerulopathies
- Acute Kidney Injury Research
- Liver Disease Diagnosis and Treatment
- Hormonal Regulation and Hypertension
- Frailty in Older Adults
- Pharmacological Effects and Toxicity Studies
- Magnesium in Health and Disease
- Heart Failure Treatment and Management
- Endoplasmic Reticulum Stress and Disease
- Diabetes Treatment and Management
- Advanced Glycation End Products research
- Bladder and Urothelial Cancer Treatments
- Cardiovascular Function and Risk Factors
- Neurological and metabolic disorders
- Vitamin D Research Studies
- Erythropoietin and Anemia Treatment
National Taiwan University Hospital
2016-2025
National Taiwan University
2015-2024
Ministry of Health and Welfare
2000-2024
Taipei Medical University-Shuang Ho Hospital
2023-2024
Taipei Medical University
2023-2024
National Yang Ming Chiao Tung University
2017
Soochow University
2017
Institute of Statistical Science, Academia Sinica
2017
Bridge University
2014-2016
Lillestrøm Centre of Expertise
2016
OBJECTIVE The annual risk among patients with diabetes of reaching end-stage renal disease (ESRD) is largely unknown worldwide. This study aimed to compare the incidence diabetes-related ESRD by creating a global atlas during 2000–2015. RESEARCH DESIGN AND METHODS was calculated as quotient number incident divided total after subtraction existing ESRD. estimated prevalence and were validated use data provided Fresenius Medical Care, Germany, previously reported data, respectively. RESULTS...
Chronic kidney disease (CKD) is known to be associated with increased all-cause and cardiovascular mortality, but no large studies examined the cancer-specific mortality in non-dialysis-dependent CKD patients. Such outcome data are needed for proper allocation of resources would help develop better preventive services.Between 1998 1999, 123,717 adults were recruited from four health screening centers Taiwan. The estimated glomerular filtration rate was calculated using four-variable...
Endoplasmic reticulum (ER) stress-associated apoptosis plays a role in organ remodeling after insult. The effect of ER stress on renal tubular damage and fibrosis remains controversial. This study aims to investigate whether is involved destruction interstitial vivo. Renal cell was proven by terminal deoxynucleotidyl transferase dUTP nick end-labeling (TUNEL) stain poly-ADP ribose polymerase expression the unilateral ureteral obstruction (UUO) kidney. evoked confirmed upregulation...
Background. Residual renal function (RRF) at the initiation of peritoneal dialysis (PD) therapy can predict patient outcome. However, RRF declines with time variable rates in different patients. This study was performed to compare impact baseline and rate decline on survival death-censored technique after long-term PD.
Studies addressing the association of metabolic syndrome and insulin resistance with risks incident chronic kidney disease (CKD) progression renal function were either lacking or inconclusive. The aim this study was to define effect on development new CKD decline in function. A prospective cohort conducted at a tertiary university-based hospital Taiwan. We studied total 1456 Asians 65 older who followed for an average 3.15 yr. Within cohort, we measured using homeostasis model assessment...
Multidisciplinary care is advocated as an effective chronic kidney disease treatment program in a few, but not all, studies. Our study aimed to evaluate the effect of multidisciplinary on renal outcome and patient survival using larger cohort.A total 1382 patients, ages 18-80 years, with stage 3B-5, nephrology outpatient clinics were enrolled. Using age, sex, stage, diabetes mellitus variables, 592 participants matched 614 nonmultidisciplinary patients. The primary outcomes long-term...
Perfluorinated chemicals (PFCs) have been largely used for years in a variety of products worldwide. However, the toxic effect PFCs on exposure to liver general population has not yet determined.In this study, 2,216 adults (18 age or older) were recruited National Health and Nutrition Examination Survey (NHANES) 1999-2000 2003-2004 determine relationship between serum level levels enzymes. The data adjusted all other confounding variants.After performing mathematical analysis, we determined...
Renal tubulointerstitial fibrosis is the common and final pathologic change of kidney in end-stage renal disease. Interesting, endoplasmic reticulum (ER) stress known to contribute pathophysiological mechanisms during development fibrosis. Here, we investigated effects chemical chaperon sodium 4-phenylbutyrate (4-PBA) on vivo vitro. In a rat unilateral ureteral obstruction (UUO) model, 4-PBA mimicked endogenous ER kidneys significantly reduced glucose regulated protein 78 (GRP78),...
Malnutrition-inflammation score (MIS) is a comprehensive and quantitative system to assess malnutrition-inflammation complex syndrome, strong correlation between MIS morbidity/mortality in maintenance hemodialysis (MHD) patients had been demonstrated. However, there no cut-off value of categorize into high risk or low patients.A total 257 chronic stable ambulatory adult MHD from Far Eastern Memorial Hospital were enrolled for the study. The each patient was recorded at initiation study...
Objective— Vascular calcification (VC) is a major cause of mortality in patients with end-stage renal diseases. Biomarkers to predict the progression VC early are urgent demand. Approach and Results— We identified circulating, cell-free microRNAs as potential biomarkers using vitro models which both rat human aortic vascular smooth muscle cells were treated high levels phosphate mimic uremic hyperphosphatemia. Using an Affymetrix microRNA array, we found that miR-125b miR-382 expression...
Abstract Acute kidney injury (AKI) is associated with higher hospital mortality. However, the relationship between geriatric AKI and in-hospital complications unclear. We prospectively enrolled elderly patients (≥65 years) from general medical wards of National Taiwan University Hospital, part whom presented at admission. recorded subsequent complications, including catastrophic events, incident gastrointestinal bleeding, hospital-associated infections new-onset electrolyte imbalances....
Polypharmacy is common in the elderly due to multimorbidity and interventions. However, temporal association between polypharmacy renal outcomes rarely addressed recognized. We investigated cardiovascular (CV) risk of acute kidney injury (AKI) patients. used Taiwan National Health Insurance PharmaCloud system investigate relationship cumulative CV medications 3 months before admission AKI at their general medical wards a single center. Community-dwelling patients (>60 years) were...