A5002000052- Bone health and osteoporosis research
- Hip and Femur Fractures
- Frailty in Older Adults
- Nutrition and Health in Aging
- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical Practices and Patient Outcomes
- Chronic Disease Management Strategies
- Cardiac, Anesthesia and Surgical Outcomes
- Bone Metabolism and Diseases
- Bone fractures and treatments
- Dementia and Cognitive Impairment Research
- Bone health and treatments
- Medication Adherence and Compliance
- Bone and Joint Diseases
- Osteoarthritis Treatment and Mechanisms
- Geriatric Care and Nursing Homes
- Physical Activity and Health
- Blood Pressure and Hypertension Studies
- Intensive Care Unit Cognitive Disorders
- Dialysis and Renal Disease Management
- Body Composition Measurement Techniques
- Chronic Kidney Disease and Diabetes
- Pharmaceutical studies and practices
- Heart Failure Treatment and Management
- Advanced Breast Cancer Therapies
National Taiwan University Hospital
2016-2025
University of Malaya
2024
Alice Ho Miu Ling Nethersole Hospital
2024
National Taiwan University
2012-2023
Singapore General Hospital
2018-2020
National Central University
2019
Eli Lilly (Spain)
2017-2018
Orlando Health
2017-2018
Istituto Oncologico Veneto
2018
University of California, Los Angeles
2016-2017
Abstract Background Few randomized controlled trials (RCTs) report interventions targeting improvement of frailty status as an outcome. Methods This RCT enrolled 117 older adults (65-79 years age) in Toufen, Taiwan who scored 3-6 on The Chinese Canadian Study Health and Aging Clinical Frailty Scale Telephone Version then score ≥1 the Cardiovascular Phenotypic Classification (CHS_PCF). With a two by factorial design, subjects were randomly assigned to (Exercise nutrition, EN, n = 55 or...
Abstract Diabetic myopathy, a less studied complication of diabetes, exhibits the clinical observations characterized by muscle mass, weakness and reduced physical functional capacity. Accumulation advanced glycation end‐products ( AGEs ), known to play role in diabetic complications, has been identified ageing human skeletal muscles. However, myopathy remains unclear. Here, we investigated effects on myogenic differentiation atrophy vivo vitro . We also evaluated therapeutic potential...
To develop cut-off points of muscle mass, gait speed and handgrip strength; to examine the prevalence sarcopenia, relationship between sarcopenia stages functional limitations disability by using these points.We pooled individual participant data 2867 community-dwelling older adults from five cohort studies. We defined point a mass index (ASM/ht(2)) as values two standard deviations below sex-specific means young population or 20th percentile distribution in our study population. The...
Abstract Background Exercise, nutrition, and psychological interventions may all have positive impacts on frailty sarcopenia. However, it is not known whether an integrated care programme with three components can be beneficial the intensity of such also certain. In this study, we aim to determine effectiveness two levels Methods A randomized control trial was conducted at community hospitals in Taiwan. Older adults (65–79 years age, N = 289) who scored ≥1 Cardiovascular Health Study...
Renal tubulointerstitial fibrosis is the common and final pathologic change of kidney in end-stage renal disease. Interesting, endoplasmic reticulum (ER) stress known to contribute pathophysiological mechanisms during development fibrosis. Here, we investigated effects chemical chaperon sodium 4-phenylbutyrate (4-PBA) on vivo vitro. In a rat unilateral ureteral obstruction (UUO) model, 4-PBA mimicked endogenous ER kidneys significantly reduced glucose regulated protein 78 (GRP78),...
Osteoporosis is a major health issue. By 2050, greater than 2-fold increase in patients number with hip fractures will occur Asia representing 50% of all worldwide. For the Asia-Pacific (AP) region, more efforts on controlling osteoporosis and subsequent are crucial. Bone mineral density (BMD) by dual energy X-ray absorptiometry (DXA) commonly used to diagnose monitor treatment. However, inconvenience, cost, limited availability DXA delay detection BMD changes after treatment initiation...
Guidelines for doctors managing osteoporosis in the Asia-Pacific region vary widely. We compared 18 guidelines similarities and differences five key areas. then used a structured consensus process to develop clinical standards of care diagnosis management improving quality care. Minimum assessment are needed (AP) inform practice (CPGs) improve present framework these describe its development. conducted comparative analysis existing CPGs AP using "5IQ" model (identification, investigation,...
Abstract Background Little is known about the prevalence and correlates of behavioral psychiatric symptoms dementia in community‐dwelling elders with or mild cognitive impairment (MCI). Methods 512 people Mini‐Mental State Examination (MMSE) scores < 24 a decline at least 4 points over two administrations, their knowledgeable informants (KI) were enrolled MMCS. The classification subjects as having MCI was based on neuropsychological battery four tests, not clinical diagnostic evaluation....
Background. The role of behavioral and psychological symptoms as an independent risk factor nursing home placement (NHP) in cognitively impaired elders has been controversial.
Background. Little is known about the terminal trajectories of functional decline among long-term care (LTC) residents dying with different diseases.
Our aim was to compare the practicability of six different potentially inappropriate medication (PIM) criteria in geriatric outpatients with polypharmacy.We analysed baseline data from Medication Safety Review Clinic Taiwanese Elders (MSRC-Taiwan) study. The prevalence and correlates PIMs were determined on basis developed USA, Canada, France, Norway, Ireland Thailand. percentage considered as drug-related problems problem-solving rate are reported.In 193 participants, PIM varied 24 73%....
ABSTRACT Proinflammatory cytokine interleukin‐1β (IL‐1β) stimulates several mediators of cartilage degradation and plays an important role in the pathogenesis osteoarthritis (OA). Honokiol, a low molecular weight natural product isolated from Magnolia officinalis , has been shown to possess anti‐inflammatory effect. Here, we used vitro model inflammation investigate therapeutic potential honokiol OA. Human OA chondrocytes were cultured pretreated with (2.5–10 µM) or without IL‐1β (10 ng/ml)....
Epidemiological studies have reported that the prevalence of diabetes in women > 40 years age, especially those postmenopausal phase, was higher than men areas with high levels arsenic drinking water. The detailed effect on glucose metabolism/homeostasis condition is still unclear.We investigated effects at doses relevant to human exposure from water blood regulation estrogen-deficient female mice.Adult mice who underwent ovariectomy or sham surgery were exposed contaminated trioxide (0.05...
Diabetic hyperglycemia has been suggested to play a role in osteoarthritis. Peroxisome proliferator-activated receptor-γ (PPARγ) was implicated several pathological conditions including diabetes and inflammation. The detailed effects mechanisms of on cartilage damage still need be clarified. Here, we investigated the PPARγ hyperglycemia-triggered chondrocyte/cartilage damages using human chondrocyte culture model diabetic mouse model. Human chondrocytes were cultured treated with high...