A5005439928- Bone health and osteoporosis research
- Bone health and treatments
- Bone Metabolism and Diseases
- Nutrition and Health in Aging
- Growth Hormone and Insulin-like Growth Factors
- Bone and Joint Diseases
- Hip and Femur Fractures
- Pituitary Gland Disorders and Treatments
- Vitamin D Research Studies
- Adrenal and Paraganglionic Tumors
- Thyroid Cancer Diagnosis and Treatment
- Estrogen and related hormone effects
- Thyroid Disorders and Treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Parathyroid Disorders and Treatments
- Nutritional Studies and Diet
- Body Composition Measurement Techniques
- Connective tissue disorders research
- Bone fractures and treatments
- Liver Disease Diagnosis and Treatment
- Muscle metabolism and nutrition
- Medical Imaging and Analysis
- Cancer Diagnosis and Treatment
- Nutrition, Health and Food Behavior
- Congenital heart defects research
Ajou University
2016-2025
University Medical Center
2024
Institute on Aging
2014-2024
Konkuk University
2024
Yeungnam University Medical Center
2024
Yeungnam University College
2024
Korea University
2024
Yonsei University
1992-2024
Ajou University Hospital
1997-2023
St George's Hospital
2021
Sarcopenia is an important factor of functional impairment related to aging. This study conducted investigate the prevalence sarcopenia and sarcopenic obesity in Korean population. Representative men (4,486) women (5,999) aged 20 years or older were analyzed from Fourth National Health Nutritional Examination Surveys. was classified into Class I defined relative skeletal muscle mass loss within 1–2 SD gender-specific mean for healthy young adults II below 2 SD. Relative represented by...
Hip fracture is a major public health problem. Earlier studies projected that the total number of hip will increase dramatically by 2050, and most occur in Asia. To date, only few provided updated projection, none them focused on projection Thus, it essential to provide up date prediction Asia, evaluate direct medical cost We 9 Asian Federation Osteoporosis Societies members using incidence rate population size. show from 1,124,060 2018 2,563,488 2.28-fold increase. This mainly due changes...
Objective: this study examined the association of physical activity with sarcopenia and sarcopenic obesity among community-dwelling Korean elderly. Methods: subjects consisted 2,264 aged 65 years or older in 2008–09 Korea National Health Nutrition Examination Survey. Sarcopenia was defined as 2 SD below mean appendicular skeletal muscle/weight for healthy young adults. Obesity waist circumference ≥90 cm men ≥85 women. Levels were classified using metabolic equivalent task method. Results:...
For the prevention of osteoporotic fracture, adequate screening and treatment are important. However, there few published data on diagnosis rates osteoporosis in Asia. We used from fourth Korea National Health Nutrition Examination Survey 2008-2009 to estimate nationwide prevalence, physician rate, rate adults aged 50 years older. The bone mineral density (BMD) measurements central skeletal sites (lumbar spine, femoral neck, total hip) were obtained using dual-energy X-ray absorptiometry...
<h3>Importance</h3> The potential benefit of novel skeletal muscle anabolic agents to improve physical function in people with sarcopenia and other wasting diseases is unknown. <h3>Objective</h3> To confirm the safety efficacy bimagrumab plus new standard care on mass, strength, compared alone community-dwelling older adults sarcopenia. <h3>Design, Setting, Participants</h3> This double-blind, placebo-controlled, randomized clinical trial was conducted at 38 sites 13 countries among men...
several studies have found nutrients, including antioxidants, to be associated with sarcopenia. However, whether specific foods, such as vegetables and fruits, are sarcopenia has not been studied.to examine the association of frequency fruits consumption in older people.this study used cross-sectional data from Fourth Korea National Health Nutrition Examination Survey 2008-09. Subjects were community-dwelling 823 men 1,089 women aged ≥65 years. Frequency food group was obtained by using...
Recently, it was reported that 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors increased bone mineral density (BMD) in mice. We studied the effect of HMG-CoA on BMD type 2 diabetes mellitus by a retrospective review medical records. Sixty-nine diabetic patients were included. The control group (n = 33) did not take inhibitors. treatment 36) administered either lovastatin, pravastatin, or simvastatin. spine, femoral neck, trochanter, and total hip measured dual-energy...
We investigated the cutoff values of surrogate insulin resistance for diagnosing metabolic syndrome in Korean adults. The data from 976 non-diabetic individuals (484 men and 492 women) aged 30-79 yr were analyzed. determined odds ratios prevalence according to quartiles fasting insulin, homeostasis model (HOMA-IR), quantitative sensitivity check index (QUICKI) as independent variables, while adjusting age, sex, body mass index. HOMA-IR, QUICKI estimated by areas under receiver-operating...
See also: Commentaire de travail D. Park et al., pp. 7Endoscopy 2008; 40(01): 88-89DOI: 10.1055/s-0032-1306799
It is well established that insulin-like growth factor (IGF)-I critical for the regulation of peak bone mineral density (BMD) and width. However, role systemic vs. local IGF-I not understood. To determine plays in regulating BMD width, we crossed flox/flox mice with procollagen, typeIIalphaI-Cre to generate conditional mutants which chondrocyte-derived was disrupted. Bone parameters were measured by dual X-ray absorptiometry at 2, 4, 8, 12 wk age peripheral quantitative computed tomography...
Abstract Background Serum vitamin D levels have been reported to be associated with individual components of body composition. However, the relationship between serum and combined indices adverse composition is largely unknown. This cross‐sectional study examined association osteosarcopenic obesity in a nationally representative sample middle‐aged older adults. Methods We analysed Korea National Health Nutrition Examination Surveys (IV V) conducted 2008–2010, consisting 5908 (2485 men, 3423...
Osteoporosis is a major health issue. By 2050, greater than 2-fold increase in patients number with hip fractures will occur Asia representing 50% of all worldwide. For the Asia-Pacific (AP) region, more efforts on controlling osteoporosis and subsequent are crucial. Bone mineral density (BMD) by dual energy X-ray absorptiometry (DXA) commonly used to diagnose monitor treatment. However, inconvenience, cost, limited availability DXA delay detection BMD changes after treatment initiation...
Guidelines for doctors managing osteoporosis in the Asia-Pacific region vary widely. We compared 18 guidelines similarities and differences five key areas. then used a structured consensus process to develop clinical standards of care diagnosis management improving quality care. Minimum assessment are needed (AP) inform practice (CPGs) improve present framework these describe its development. conducted comparative analysis existing CPGs AP using "5IQ" model (identification, investigation,...
Diabetes is a major health problem in Korea. However, interest the quality of life patients with diabetes low. We examined effects on health-related (HRQoL) and compared it HRQoL general Korean population using Fourth Korea National Health Nutrition Examination Survey (KNHANES IV) (2007-2009).Using KNHANES IV data, we EuroQol (EQ)-5D EQ-visual analogue scale (VAS) scores after adjusting for sociodemographic psychosocial factors as well comorbidities (hypertension, heart disease, stroke,...
Rheumatoid arthritis (RA) is a risk factor for bone fragility, and its effect on fracture independent of mineral density (BMD). The trabecular score (TBS) new indirect parameter quality. In this study, BMD the TBS were compared between female postmenopausal RA patients with those without vertebral fractures (VFs). This study had cross-sectional design. Two hundred seventy-nine women aged 50 years or older included in study. measurements performed same vertebrae as measurements. Among 279...
Early prevention of sarcopenia could be an important strategy for muscle retention, but most studies have focused on subjects aged 65 or older. Therefore, in this study we investigated the effects leucine-enriched protein supplementation condition a sample including late middle-aged adults. A 12-week intervention was performed 120 healthy community-dwelling adults by providing either supplement [protein 20g(casein 50%+ whey 40%+ soy 10%, total leucine 3000 mg), vitamin D 800IU(20 ug),...
This study aimed to present the Asia-Pacific consensus on long-term and sequential therapy for osteoporosis, offering evidence-based recommendations effective management of this chronic condition. The primary focus is achieving optimal fracture prevention through a comprehensive, individualized approach. A panel experts convened develop statements by synthesizing current literature leveraging clinical expertise. review encompassed anti-osteoporosis medication goals, first-line treatments...
BackgroundDenosumab is a potent anti-resorptive agent widely used for osteoporosis. However, its discontinuation results in 'rebound phenomenon' of rapid bone loss, necessitating transition to alternative therapies. Despite this, there limited evidence guide the selection most effective agent, particularly among bisphosphonates. This study aimed evaluate efficacy different therapies following denosumab real-world clinical setting. MethodsThis retrospective included 360 patients (low-dose...