A5103015742- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Gastrointestinal disorders and treatments
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Viral-associated cancers and disorders
- Metastasis and carcinoma case studies
- Cancer, Lipids, and Metabolism
- Vascular Malformations and Hemangiomas
- Hepatocellular Carcinoma Treatment and Prognosis
- Genetic factors in colorectal cancer
- Sarcoma Diagnosis and Treatment
- Cancer-related gene regulation
- Helicobacter pylori-related gastroenterology studies
- Tumors and Oncological Cases
- Glycosylation and Glycoproteins Research
- Epigenetics and DNA Methylation
- Radiomics and Machine Learning in Medical Imaging
- Lymphoma Diagnosis and Treatment
- Lung Cancer Research Studies
- Cancer Genomics and Diagnostics
- Salivary Gland Tumors Diagnosis and Treatment
- Dermatologic Treatments and Research
- Intestinal Malrotation and Obstruction Disorders
- Cervical Cancer and HPV Research
Kyungpook National University Hospital
2010-2023
Kyungpook National University
2012-2023
Weatherford College
2022
Kyungpook National University Medical Center
2012-2017
Korea University
2013
Wayne State University
2004-2005
University of California, San Francisco
2003
As a result of various independently proposed nomenclatures and classifications, there is confusion in the diagnosis prediction biological behavior gastroenteropancreatic neuroendocrine tumors (GEP-NETs). A comprehensive nationwide study needed order to understand characteristics GEP-NETs Korea.We collected 4,951 pathology reports from 29 hospitals Korea between 2000 2009. Kaplan-Meier survival analysis was used determine prognostic significance clinicopathological parameters.Although...
To identify candidate genes that could be used as diagnostic and therapeutic targets for hepatocellular carcinoma (HCC), we searched the are overexpressed in HCC by combining representational difference analysis microarray. Genes such glypican‐3 (GPC3), insulin‐like growth factor 2, long‐chain fatty‐acid‐coenzyme A ligase 4, farnesyl diphosphate synthase were frequently identified our screening. Northern blot with these four confirmed their overexpression HCC. Among them found GPC3...
See also: Commentaire de travail D. Park et al., pp. 7Endoscopy 2008; 40(01): 88-89DOI: 10.1055/s-0032-1306799
The prognosis of the patients with early recurrence after curative hepatectomy for hepatocellular carcinoma (HCC) is usually dismal.One hundred twenty-four underwent resection HCC at Kyungpook National University Hospital from January 2002 to December 2006. An was defined as a within 2 years resection. risk factors associated an were analyzed well other correlated survival recurrence.Early disease developed in 56 (45.2%). tumor size larger than 5 cm (P = 0.001) and presence micrometastasis <...
This study investigated the clinical relevance and prognostic impact of overall expression programmed cell death protein ligand-1 (PD-L1) ligand-2 (PD-L2), in patients with Epstein-Barr virus-associated gastric cancer (EBVaGC).After reviewing 1318 consecutive cases surgically resected or endoscopic submucosal dissected cancers, status PD-L1 PD-L2 120 EBVaGC identified by EBV-encoded RNA situ hybridisation was retrospectively analysed using immunohistochemistry (IHC). For each IHC marker,...
Background/Aims: The superiority of endoscopic ultrasound-guided fine needle biopsy (EUS-FNB) over EUS-guided aspiration (EUS-FNA) remains controversial.Given the lack studies analyzing histologic specimens acquired from EUS-FNB or EUS-FNA, we compared proportion core obtained both techniques.Methods: A total 58 consecutive patients with solid mass lesions were enrolled and randomly assigned to EUS-FNA groups.The opposite was used after failure tissue acquisition using initial up three...
Fatty acid‐CoA ligase 4 (FACL4) is a central enzyme controlling the unesterified arachidonic acid (AA) level in cells. It has been shown that FACL4 blocks apoptosis and promotes colon carcinogenesis by lowering cellular of AA. Consistent with this, upregulated adenocarcinoma. The status other tumors including hepatocellular carcinoma (HCC) not known. Here, we report overexpressed human HCC compared adjacent normal liver tissues. mRNA protein were 5 out 12 (41.7%) 3 8 (37.5%) cases HCC,...
// Byung Woog Kang 1, * , YongHun Choi 2, 3, Oh Kyoung Kwon 4 Seung Soo Lee Ho Young Chung Wansik Yu Han Ik Bae 5 An Na Seo Hyojeung 6 Suk Kyeong 7 Seong Woo Jeon 8 Keun Hur 3 Jong Gwang Kim 1 Department of Oncology/Hematology, Kyungpook National University Hospital, School Medicine, Cancer Research Institute, University, Daegu, South Korea 2 Biochemistry and Cell Biology, Matrix BK21 Plus KNU Biomedical Convergence Program, Science, Surgery, Pathology, College Pharmacy, Institute...
Protein gene product 9.5 (PGP9.5) is a neurospecific peptide that removes ubiquitin from ubiquitinated proteins and prevents them being targeted for degradation by proteosomes. Its expression potential marker of non‐small lung cancer, invasive colorectal cancer esophageal squamous cell carcinoma. Gallbladder (GB) the most common malignant tumor biliary tract usually associated with gallstone disease, late diagnosis, unsatisfactory treatment poor prognosis. To understand role PGP9.5 in GB we...
Mesenchymal hamartoma (MH) of the liver is an uncommon benign lesion related to ductal plate malformation. It usually cystic and mainly composed myxoid mesenchymal tissue with tortuous or bile ducts. In order characterize clinicopathological features MH, Korean Gastrointestinal Pathology Study Group collected a total 17 MH cases diagnosed in 7 hospitals from 1992 2002 compared clinicopathologic findings those solid variant. Among cases, (41%) were solid. The form showed higher serum level...
Overexpression of cyclooxygenase 2 (COX-2) is associated with tumorigenesis in a number human cancers. Recentiy, COX-2 overexpression has also been reported hepatocellular carcinoma (HCC), especially well-differentiated HCC. However, doubt cast on these claims concerning Here we show by Western blot analysis that protein ievei higher the adjacent chronic hepatitis lever than tumors themselves. We show, im-munohistochemical staining, mean intensity expression cirrhotic liver specimens...
Discrepancies can occur between the histopathological findings from forceps biopsy and endoscopic mucosal resection (EMR), occasionally in embarrassing cases tumorous tissue is not found at EMR. The aim of present study was to evaluate clinical, endoscopic, histological features gastric tumors patients with pathololgically negative EMR.We retrospectively reviewed data all tumor treated EMR or submucosal dissection (ESD) August 1999 April 2007 our institution, enrolled into no resection....
Background/Aims Determining the cause of suspected biliary stricture is often challenging in clinical practice. We aimed to compare diagnostic yields endoscopic ultrasound-guided tissue sampling (EUS-TS) and retrograde cholangiopancreatography-guided (ERCP-TS) patients with at different primary lesions. Methods enrolled who underwent same-session EUS- ERCP-TS for evaluation stricture. Forceps biopsy and/or brush cytology intraductal lesions fine-needle aspiration solid mass were performed...
Epstein-Barr virus (EBV)-associated gastric cancer (GC) is known to harbor a significant enrichment of phosphatidylinositol 4, 5-biphosphate 3- kinase catalytic subunit alpha isoform (PIK3CA). Therefore, this study investigated the clinical relevance and prognostic role PIK3CA mutations in patients with EBV-GC.After reviewing 1,318 consecutive cases surgically resected GC, 120 were identified as EBV-positive using EBV-encoded RNA situ hybridization. formalin-fixed paraffin-embedded surgical...