A5084299599- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Cancer-related molecular mechanisms research
- Colorectal Cancer Treatments and Studies
- MicroRNA in disease regulation
- Breast Implant and Reconstruction
- HER2/EGFR in Cancer Research
- Cancer Treatment and Pharmacology
- Cerebrovascular and genetic disorders
- Genetic factors in colorectal cancer
- Cell Adhesion Molecules Research
- Food Quality and Safety Studies
- Extracellular vesicles in disease
- Advanced Breast Cancer Therapies
- Hematopoietic Stem Cell Transplantation
- Gastric Cancer Management and Outcomes
- Glaucoma and retinal disorders
- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Cancer, Hypoxia, and Metabolism
- Circular RNAs in diseases
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Cancer Genomics and Diagnostics
- Lymphoma Diagnosis and Treatment
Kyungpook National University Hospital
2016-2025
University of Michigan
2012-2025
VA Ann Arbor Healthcare System
2010-2025
Kyungpook National University
2015-2024
Inje University Haeundae Paik Hospital
2013-2024
Catholic University of Daegu
2018-2023
Yeungnam University College
2010-2021
Yeungnam University
2010-2021
Yeungnam University Medical Center
2016-2021
Michigan United
2012-2020
Lignocellulosic biomass is an attractive renewable resource for future liquid transport fuel. Efficient and cost-effective production of bioethanol from lignocellulosic depends on the development a suitable pretreatment system. The aim this study to investigate new method that highly efficient effective downstream biocatalytic hydrolysis various materials, which can accelerate commercialization.The optimal conditions hydrogen peroxide-acetic acid (HPAC) were 80 °C, 2 h, equal volume mixture...
Currently, there are no molecular biomarkers for the early detection of breast cancer. This study focused on identifying surface proteins found circulating extracellular vesicles (EVs) detecting early-stage cancer.Circulating EVs, isolated from plasma 10 patients with cancer (stages I and II) 5 healthy controls, were analyzed using LC-MS/MS. Developmental endothelial locus-1 protein (Del-1) was selected as a candidate biomarker. Two different ELISAs used to measure Del-1 in samples controls...
Extracellular vesicles (EVs) secreted from cancer cells have potential for generating biomarker signatures. Fibronectin (FN) was selected as a candidate, due to the presence in surface on EVs human breast cell lines. A subsequent study used two types of enzyme-linked immunosorbent assays (ELISA) determine these proteins plasma samples disease-free individuals (n=70), patients with BC (n=240), after surgical resection (n=40), benign tumor (n=55), and non-cancerous diseases (thyroiditis,...
Jeotgal (醢) is a traditional Korean fermented food with thousands years of history kimchi and other jang (fermented soybean products, 醬). The was proved by research from historical literature antique architecture. developed along (豆醬), fish (魚醬), meat (肉醬) as part (醬) up to the Chosun Dynasty it always offered during ancestral rites or ceremonies. According documents written women, jeotgal had been used seasonings condiments that were popular especially for women rather than served rites. In...
Ovarian serous carcinoma is a highly aggressive neoplastic disease in women.Our previous studies have demonstrated Notch3 gene amplification and upregulation many ovarian carcinomas Notch pathway activity contributed to drug resistance.Among different ligands, Jagged1 most dominant cancer, correlated with expression level tissues.In this study, we found that depended on activation.Knockdown of either or RBPjk, Notchinteracting transcription factor critical signaling, suppressed cancer...
<b><i>Objectives:</i></b> The clinical significance of aquaporin-1 (AQP1), aquaporin-3 (AQP3), and aquaporin-5 (AQP5) expression was analyzed in a large number patients with colon cancer. <b><i>Methods:</i></b> AQP1, AQP3, AQP5 investigated based on the immunohistochemistry tissue microarray specimens from 486 cancer who underwent curative surgery. Scores were given to staining intensity percentage positive cells, score defined as sum these...
The anti-cancer effect of high doses intravenous vitamin C (high-dose C) remains controversial despite growing evidence that high-dose exerts anti-tumorigenic activity by increasing the amount reactive oxygen species in cancer cells without meaningful toxicities. Therefore, this study attempted to demonstrate vitro combination with conventional treatment breast cancer.The pro-apoptotic effects (1.25 20 mM) or agents (eribulin mesylate, tamoxifen, fulvestrant, trastuzumab) were estimated...
// Hye Jin Kim 1 , Gyu-Seog Choi Jun Seok Park Soo Yeun Seung Hyun Cho 2 Jung Lee 3 Byung Woog Kang and Jong Gwang Colorectal Cancer Center, Kyungpook National University Medical School of Medicine, University, Daegu, Korea Department Radiology, Oncology/Hematology, Correspondence to: Choi, email: kyuschoi@mail.knu.ac.kr Keywords: lateral pelvic lymph node dissection, locally advanced rectal cancer, preoperative chemoradiation Received: May 24, 2017 Accepted:...
We evaluated the role of long noncoding ribonucleic acid (lncRNA) in breast cancer cell lines by quantitative reverse transcription-polymerase change reaction.The effects small NF90-associated RNA (snaR) with interference on proliferation, migration and invasion MDA-MB-231 cells were observed 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide, wound healing transwell assay.Among 90 lncRNAs, E2F transcription factor 4, p107/p130-binding (E2F4) antisense, insulin-like growth 2...
Regulator of G protein signaling 2 (RGS2) is a member family proteins that functions as GTPase-activating (GAP) for Gα subunits. RGS2 mRNA expression lower in breast cancerous tissues than normal tissues. In addition, also MCF7 (cancerous cells) MCF10A (normal cells). Here we investigated whether inhibits growth cancer cells. overexpression cells inhibited epidermal factor- or serum-induced proliferation. HEK293T expressing RGS2, cell was significantly suppressed (In exogenous resulted the...
Invasive breast carcinoma (IBC) with neuroendocrine (NE) differentiation has been controversial in terms of its definition and clinical outcome. We investigated the incidence significance NE patients IBC.We performed immunohistochemistry for markers, chromogranin-A synaptophysin on 1428 IBC samples using tissue microarrays classified cases into two groups, focal (1-49% tumour cells positive any marker) diffuse (≥50% positive) groups. Fifty-nine (4.1%) showed immunohistochemically, majority...
Abstract Background and Objectives Occult breast cancer (OBC) accounts for 0.3–1.0% of all cancers is a rare presentation the disease. The present retrospective study examined overall survival prognostic factors associated with OBC in Korea. Method included 142 patients identified from Korean Breast Cancer Society registry January 1990 to December2009. All had pathologically positive axillary lymph nodes (N1–N3) radiologically negative in‐breast lesions (T0/Tx) based on review database....
Abstract Peritumoral edema (PE) of breast cancer at T2-weighted MR images is considered a poor prognostic sign and may represent the microenvironment surrounding tumor; however, its histopathological mechanism remains unclear. The purpose study was to identify describe detailed characteristics associated with PE preoperative MRI in patients. This retrospective included patients who had undergone surgery between January 2011 December 2012. Two radiologists determined presence consensus based...
The axillary reverse mapping (ARM) technique to identify and preserve arm nodes during sentinel lymph node biopsy (SLNB) or dissection (ALND) was developed prevent lymphedema. purpose of this study investigate the location metastatic rate node, evaluate short term incidence lymphedema after preserving surgery.From January 2009 October 2010, 97 breast cancer patients who underwent ARM were included. Blue-dye (2.5 mL) injected into ipsilateral upper-inner arm. At least 20 minutes injection,...
Epidermal growth factor receptor (EGFR) is considered a potential therapeutic target for anti-EGFR therapy in triple-negative breast cancer (TNBC). However, the frequency of EGFR gene mutation TNBC low and varies with ethnicity. This study aimed to investigate incidence TNBC.EGFR protein expression was evaluated by immunohistochemistry tissue microarrays 493 cases using four different primary antibodies, which included mutation-specific antibodies. For an immunoreactivity level ≥1+, we...