Currently, there are no molecular biomarkers for the early detection of breast cancer. This study focused on identifying surface proteins found circulating extracellular vesicles (EVs) detecting early-stage cancer.Circulating EVs, isolated from plasma 10 patients with cancer (stages I and II) 5 healthy controls, were analyzed using LC-MS/MS. Developmental endothelial locus-1 protein (Del-1) was selected as a candidate biomarker. Two different ELISAs used to measure Del-1 in samples controls...

Extracellular vesicles (EVs) secreted from cancer cells have potential for generating biomarker signatures. Fibronectin (FN) was selected as a candidate, due to the presence in surface on EVs human breast cell lines. A subsequent study used two types of enzyme-linked immunosorbent assays (ELISA) determine these proteins plasma samples disease-free individuals (n=70), patients with BC (n=240), after surgical resection (n=40), benign tumor (n=55), and non-cancerous diseases (thyroiditis,...

Despite the popularity of breast-conserving surgery (BCS), which constitutes 50-60% all breast cancer surgeries, discussions regarding cosmetic results after BCS are not specifically conducted. The simple conservation tissue is no longer adequate to qualify for completion. incorporation oncological and plastic techniques allows complete resection local disease while achieving superior outcome. Oncoplastic can be performed in one following two ways: 1) volume displacement 2) replacement...

The anti-cancer effect of high doses intravenous vitamin C (high-dose C) remains controversial despite growing evidence that high-dose exerts anti-tumorigenic activity by increasing the amount reactive oxygen species in cancer cells without meaningful toxicities. Therefore, this study attempted to demonstrate vitro combination with conventional treatment breast cancer.The pro-apoptotic effects (1.25 20 mM) or agents (eribulin mesylate, tamoxifen, fulvestrant, trastuzumab) were estimated...

We evaluated the role of long noncoding ribonucleic acid (lncRNA) in breast cancer cell lines by quantitative reverse transcription-polymerase change reaction.The effects small NF90-associated RNA (snaR) with interference on proliferation, migration and invasion MDA-MB-231 cells were observed 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide, wound healing transwell assay.Among 90 lncRNAs, E2F transcription factor 4, p107/p130-binding (E2F4) antisense, insulin-like growth 2...

Abstract Peritumoral edema (PE) of breast cancer at T2-weighted MR images is considered a poor prognostic sign and may represent the microenvironment surrounding tumor; however, its histopathological mechanism remains unclear. The purpose study was to identify describe detailed characteristics associated with PE preoperative MRI in patients. This retrospective included patients who had undergone surgery between January 2011 December 2012. Two radiologists determined presence consensus based...

Objectives We introduce surgical outcomes regarding 300 cases of robotic thyroidectomy using a bilateral axillo-breast approach (BABA). Methods From April 2010 to October 2013, patients who underwent were analyzed and compared with open total thyroidectomy. Robotic surgery was performed snake retractor allow for complete central lymph node dissection. BABA without drains in 170 cases; subfascial dissection reduce post-operative wound adhesion. Results The learning curve 40 after that, the...

The selection of the appropriate techniqueTo select proper oncoplastic procedure, it is important to consider multiple factors including breast size/ptosis, excised volume and location tumor.As demonstrated

A more noninvasive evaluation of axillary lymph node in breast cancer is one the principal challenges treatment. To detect metastasis (ALNM) T1 cancer, we have compared ultrasonography (AUS), contrast-enhanced magnetic resonance imaging (cMRI), and (18)F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) to determine most adequate test or a combination tests.Retrospectively, 349 patients who were preoperatively examined using AUS, cMRI, PET/CT between 2008 2011 whom...

Because the average breast size of Korean women is not as large that western women, it so easy to apply oncoplastic volume displacement technique. However, we have tried use techniques work well with small-breasted women. In this study, report usefulness in superiorly located cancers small- moderate-sized breasts. Between September 2006 and August 2009, 58 were treated for cancers. All patients who selected had breasts small moderate defects. They divided into 3 groups. The groups split...

Objectives Transoral robotic thyroidectomy (TORT) is a new remote access approach to avoid cervical incision. The purpose of this study compare two approaches used incision: transoral and bilateral axillo‐breast (BABA) in thyroidectomy. Methods A total 90 patients were enrolled prospectively between September 2016 April 2017. BABA group had 43 the TORT 47 patients, respectively. Parameters including clinicopathologic data, operative time, complications, laboratory hospital stay,...

The purpose of this study was to examine the learning curve for robotic thyroidectomy using a bilateral axillo-breast approach.We examined first 100 thyroidectomies with central lymph node dissection due papillary thyroid cancer between April 2010 and August 2011. We evaluated clinical characteristics, operative time, pathologic data, complications.Operative time reduced significantly after 40 cases; therefore, patients were divided into 2 groups: group A (1 cases) B (41 cases). mean in...

Oncoplastic surgery has revolutionized the field of breast conserving (BCS). The final aims this technique are to obtain an adequate resection margin that will reduce rate local recurrence while simultaneously improving cosmetic outcomes. To successful results after oncoplastic surgery, it is imperative patients be risk-stratified based on risk factors associated with positive margins, relevant imaging studies reviewed, and confirmation negative margins confirmed during initial operation....

The purpose of this study was to compare the quality life (QoL) between conventional open and robotic total thyroidectomy in papillary thyroid carcinoma.From January 2011 July 2013, 229 patients (112 robot 117 open) were randomly selected. QoL, including overall satisfaction, cosmetic results, voice/sensory change, postoperative pain impairment swallowing, neck/shoulder movement, physical/psychological activity, recorded.The follow-up period 32.3 ± 6.3 months. satisfaction levels results...

Long noncoding RNA, snaR (small NF90-associated RNA), has been reported to be upregulated in various cancer cell lines. We evaluated the additional role of HER2-positive breast lines.We explored changes expression among selected long RNAs which have a potential proliferation or progression. The proliferation, migration, and invasion cells (SK-BR3) were by with RNA interruption 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide, wound-healing assay, Transwell assay.The was remarkably...

MicroRNAs (miRNAs) can be used to target a variety of human malignancy by targeting their oncogenes or tumor suppressor genes. The developmental endothelial locus-1 (Del-1) might under miRNA regulation. This study investigated microRNA-137 (miR-137) function and Del-1 expression in triple-negative breast cancer (TNBC) cells tissues. mRNA miRNA-137 levels were determined via qRT-PCR (MDA-MB-231, MCF7, SK-BR3, T-47D) tissues from 30 patients with TNBC. effects miR-137 on cell proliferation,...

Abstract Background Although fat necrosis is a minor postoperative complication after breast reconstruction, occasionally it mimics to tumor recurrence in patients with cancer. Therefore, the surgeon should distinguish between benign and true local recurrence. The authors evaluated clinical characteristics of reconstruction investigated natural course necrosis. Methods Between 2007 2013, total 362 underwent partial or mastectomy for cancer Kyungpook National University Hospital....

Objectives LigaSure Small Jaw ® (LSJ) was recently developed and applied to thyroid surgery along with Harmonic Focus (HF). We compared the 2 devices in open total thyroidectomy for papillary carcinoma (PTC). Study Design A prospective, randomized study. Setting Tertiary care center. Methods This study included 126 patients enrolled between December 2011 June 2012. The numbers of LSJ group HF were 64 62, respectively. Operative times, drain output, parathyroid status, complications,...

Background Most ductal carcinoma in situ (DCIS) of the breast is asymptomatic and usually manifests as calcifications screening mammography. On other hand, little known about ultrasonographic (US) features DCIS, for US rarely used diagnosis evaluation DCIS because low sensitivity detecting microcalcifications. Purpose To evaluate detection characterization women correlate these imaging findings with histopathologic features. Material Methods This retrospective study evaluated mammographic...