Abstract Peritumoral edema (PE) of breast cancer at T2-weighted MR images is considered a poor prognostic sign and may represent the microenvironment surrounding tumor; however, its histopathological mechanism remains unclear. The purpose study was to identify describe detailed characteristics associated with PE preoperative MRI in patients. This retrospective included patients who had undergone surgery between January 2011 December 2012. Two radiologists determined presence consensus based...

Abstract Emerging evidence suggests that the mammalian target of rapamcyin (mTOR) pathway is associated with radio-resistance in cancer treatment. We hypothesised phosphorylated ribosomal S6 kinase 1 (p-S6K1), a major downstream regulator mTOR pathway, may play role predicting radio-resistance. Therefore, we evaluated association p-S6K1 expression breast cell lines and patients. During median follow-up 33 (range, 0.1–111) months for 1770 primary patients who underwent surgery, expressing...

Although endocrine therapy with tamoxifen has improved survival in breast cancer patients, resistance to this remains one of the major causes mortality. In present study, we found that expression level YAP/TAZ tamoxifen-resistant MCF7 (MCF7-TR) cells was significantly increased compared cells. Knockdown siRNA sensitized MCF7-TR tamoxifen. Furthermore, targeting PSAT1, a downstream effector YAP/TAZ, enhanced sensitivity Additionally, mTORC1 activity and survivin were decreased during cell...

The fibroblast growth factor receptor (FGFR) signaling pathway is abnormally activated in human cancers, including breast cancer. Therefore, targeting the FGFR a potent strategy to treat purpose of this study was find drugs that could increase sensitivity inhibitor effects BT-474 cancer cells, and investigate combined underlying mechanisms these combinations for cell survival.Cell viability measured by MTT assay. Protein expression determined western blot analysis. mRNA detected Real-time...

To demonstrate a variety of MR imaging findings orbital inflammatory pseudotumors with extraorbital extension.We retrospectively reviewed the features five patients, who were diagnosed clinically and radiologically as having an pseudotumor extension.The types mass in apex (n = 3), diffuse form 2), myositis 1). The extension passed through superior fissure all cases, inferior two optic canal one case. lesions extended into following areas: cavernous sinus 4), middle cranial fossa Meckel's...

In the era of precision medicine, prediction ovarian function recovery from chemotherapy-induced amenorrhoea using feasible biological markers may be helpful to optimise treatment strategy for young patients with hormone receptor-positive breast cancer. The purpose this study was investigate accuracy post-chemotherapy predicting in cancer ASTRRA trial, amenorrhoea. Using data 82 participants a single institution serum levels anti-Müllerian (AMH), oestradiol, inhibin B and other clinical...

Abstract Background Using the Latissimus dorsi (LD) muscle flap is one of popular surgical technique for breast reconstruction. However, usually, long postoperative scar was remained on donor site which does not have disease. The authors applied endoscopy-assisted surgery to harvest LD Methods From July 2018 2019, five consecutive patients with cancer underwent partial mastectomy clinic-pathologic factors were analyzed and cosmetic outcomes assessed shape, scarring back. A 4–6 cm lateral...

Abstract Background Preoperative breast magnetic resonance imaging (MRI) provides more information than mammography and ultrasonography for determining the surgical plan patients with cancer. This study aimed to determine whether MRI is useful ductal carcinoma in situ (DCIS) lesions those invasive (IDC). Methods A total of 1113 cancer underwent mammography, ultrasonography, additional before surgery. The were divided into 2 groups: DCIS ( n = 199) IDC 914), their clinicopathological...

Osteoblastoma Arising from the Ethmoidal SinusEun Ja Lee, Chan Sub Park, Soon-Young Song, No Hyuck Park and Mi Sung KimAudio Available | Share

Background After publication of the findings American College Surgeons Oncology Group Z1071 trial, sentinel lymph node biopsy (SLNB) has been increasingly performed in patients with breast cancer after neoadjuvant chemotherapy (NAC). Purpose To investigate pretreatment MRI and clinical-pathologic characteristics associated failed identification NAC cancer. Materials Methods Patients who underwent SLNB between January 2015 2019 were retrospectively identified. Two radiologists independently...

Filling materials for partial defect of the breast have rarely been developed because safety and durability.Two female patients (ages, 53 50 years) with cancer underwent mastectomy sentinel lymph node biopsy.Core needle biopsy revealed an invasive ductal carcinoma in both patients. Breast ultrasound showed hypoechoic nodules irregular margins. magnetic resonance imaging irregularly shaped enhancing mass duct extension Patient 1 multifocal, masses non-mass enhancement 2.A combination method...

Introduction: Conventional transoral robotic thyroidectomy (TORT) requires an axillary incision and additional flap dissection. This study aimed to outline the first ever experiences with TORT using three ports without compare results between three-port four-port TORT. Materials Methods: A total of 100 consecutive patients were enrolled. The sample comprised 47 who underwent from November 2016 June 2017, 53 September 2018 2019. indication was anterior/posterior length thyroid <1.8 cm mass...

Background: The coronavirus disease 2019 (COVID-19) outbreak in South Korea has affected the diagnosis, treatment, and follow-up protocols of various cancers. This study investigated patterns delaying surgery for breast cancer during COVID-19 evaluated factors that may have decision to delay surgery. Methods: From February 18 April 18, 2020, which was critical period Korea, patients with who were scheduled terms their procedure. divided into two groups: non-delaying groups. association...

Neoadjuvant chemotherapy (NAC) is a standard treatment for locally advanced breast cancer, especially HER2-positive or triple negative cancer which shows good response to chemotherapy. However, because result of biomarkers is, occasionally, changed after NAC, the strategy should be differently applied patients with cancer. We compared results before and NAC evaluate association disease prognosis oncologic results.Fifty-seven underwent immunohistochemical (IHC) staining were between NAC. And...

Abstract Background: Peri-prosthetic seroma after implant insertion for breast reconstruction is a common but difficult-to-manage complication. This study aimed to compare peri-prosthetic duration and the number of aspirations associated with intravenous cannula those conventional needle. Methods: Seventy-one patients who underwent skin- or nipple-sparing mastectomy were treated seroma. When was detected, ultrasound-guided aspiration performed either by using an (n = 35) needle 36); however,...

Whether administering chemotherapy followed by tamoxifen plus a gonadotropin-releasing hormone (GnRH) agonist to treat patients with lower-risk receptor (HR)-positive, human epidermal growth factor 2 (HER2)-negative breast cancer provides greater benefit than GnRH alone remains unclear. This study aimed compare the outcomes of propensity score-matched (PSM) who underwent these types treatment plans.This retrospective included treated at our institution between 2009 and 2019. Eligible had...

Even at present, we are in the middle of novel coronavirus disease 2019 (COVID-19) pandemic and facing challenges trial error. Presently, emergency surgery for patients with suspected COVID-19 is burdensome not only but also healthcare workers. Therefore, established a surveillance system room principles managing who require surgery.A 67-year-old man was diagnosed appendicitis March 2020. His wife 10 d earlier, patient close contact her. The tested negative twice on an upper respiratory...

Purpose: This study was deigned to evaluate the ultrasonographic findings of subcutaneous and intramuscular sparganosis. Materials Methods: Nine cases histologically proven sparganosis lesions in seven patients (mean patient age, 59 years; M:F = 6:1) were reviewed retrospectively. Two had recurrent A color Doppler examination performed all cases. Results: prior history ingestion raw snake meat noted for two patients. Patients presented with a palpable mass induration (n 7) dull pain 4)....

Phosphorylated ribosomal S6 kinase 1 (pS6K1) is a major downstream regulator of the mammalian target rapamycin (mTOR) pathway. Recent studies have addressed role S6K1 in adipogenesis. pS6K1 may affect outcome estrogen depletion therapy patients with hormone-sensitive breast cancer due to its association adipogenesis and increased local levels. This study aimed investigate potential as predictive marker adjuvant aromatase inhibitor (AI) postmenopausal or ovarian function-suppressed...