A5100765100- Acute Myeloid Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Multiple Myeloma Research and Treatments
- Acute Lymphoblastic Leukemia research
- Chronic Myeloid Leukemia Treatments
- Protein Degradation and Inhibitors
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Polyomavirus and related diseases
- Histone Deacetylase Inhibitors Research
- Viral-associated cancers and disorders
- Immune Cell Function and Interaction
- Chronic Lymphocytic Leukemia Research
- Mesenchymal stem cell research
- Cancer Treatment and Pharmacology
- CAR-T cell therapy research
- COVID-19 Clinical Research Studies
- Renal Transplantation Outcomes and Treatments
- Long-Term Effects of COVID-19
- Neutropenia and Cancer Infections
- Retinoids in leukemia and cellular processes
- Galectins and Cancer Biology
- RNA Interference and Gene Delivery
- Glioma Diagnosis and Treatment
Seoul St. Mary's Hospital
2016-2025
Catholic University of Korea
2016-2025
Hanyang University
2007-2025
Fusion Academy
2025
Fusion (United States)
2025
Research Network (United States)
2025
Shaikh Khalifa Medical City
2019-2024
Seoul National University Hospital
2019-2024
Jeju National University
2022-2023
Yeouido St. Mary's Hospital
2023
The infection of a novel coronavirus found in Wuhan China (SARS-CoV-2) is rapidly spreading, and the incidence rate increasing worldwide. Due to lack effective treatment options for SARS-CoV-2, various strategies are being tested China, including drug repurposing. In this study, we used our pre-trained deep learning-based drug-target interaction model called Molecule Transformer-Drug Target Interaction (MT-DTI) identify commercially available drugs that could act on viral proteins...
We aimed to identify whether lymphopenia is a reliable prognostic marker for COVID-19. Using data derived from Korean nationwide longitudinal cohort of 5628 COVID-19 patients, we identified propensity-matched cohorts (n = 770) with group I severe (absolute lymphocyte counts [ALC]: <500/mm3, n 110), II mild-to-moderate (ALC: ≥500–<1000/mm3, 330), and III, no ≥1000/mm3, 330). A significantly higher mortality rate was associated severity: 40% in I, 22.7% II, 13.0% III (p < 0.001). At...
Abstract The infection of a novel coronavirus found in Wuhan China (2019-nCoV) is rapidly spreading, and the incidence rate increasing worldwide. Due to lack effective treatment options for 2019-nCoV, various strategies are being tested China, including drug repurposing. In this study, we used our pretrained deep learning-based drug-target interaction model called Molecule Transformer-Drug Target Interaction (MT-DTI) identify commercially available drugs that could act on viral proteins...
Hemophagocytic lymphohistiocytosis is an overwhelming systemic inflammatory process that life-threatening if not treated appropriately. We analyzed prognostic factors in patients with secondary hemophagocytic excluding malignancy. In this retrospective study, we 126 adult cases between 2001 and 2017. Treatment was based on dexamethasone or without etoposide cyclosporine. Patients who achieved a complete response by 4 weeks were defined as early stable responders, those failed to achieve but...
Abstract The cell-derived vesicles (CDVs) obtained using a proprietary extrusion process are the foundation of BioDrone platform technology. With superior productivity and versatility, this technology has garnered increasing attention in broad applications, particularly as drug delivery vehicle. Previously, we showed that CDVs exhibited varying levels expression for tetraspanin organelle membrane markers while revealing no discernible differences physical characteristics compared to...
Hypoxia-inducible factor-1 alpha (HIF-1alpha) is the regulatory subunit of heterodimeric transcription factor HIF-1 that key regulator cellular response to low oxygen tension. Under normoxic conditions, HIF-1alpha continuously degraded by ubiquitin-proteasome pathway through pVHL (von Hippel-Lindau tumor suppressor protein). hypoxic stabilized and induces target genes. Quercetin, a flavonoid with anti-oxidant, anti-inflammatory, kinase modulating properties, has been found induce...
Monitoring minimal residual disease (MRD) provides important information during treatment of hematologic malignancies. Chimerism analysis also key after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Recent advances in next-generation sequencing (NGS) have enabled identification various mutations and quantification mutant allele burden. In this study, we developed a new analytic algorithm to monitor chimerism applicable NGS multi-gene panel use identify myelodysplastic...
Abstract Venetoclax (VEN) combined with azacitidine (AZA) or decitabine (DEC) has been approved for older adults acute myeloid leukemia (AML) unfit intensive chemotherapy based on the pivotal VIALE-A trial. However, this trial only compared AZA + VEN monotherapy. Therefore, we outcomes of consecutive (65 years older) newly diagnosed AML who received DEC ( n = 230) 74) after propensity score matching to construct a one-to-one matched cohort by nearest neighbor algorithm. The median overall...
Two distinct types of systemic amyloidosis—transthyretin (ATTR) and light chain (AL)—account for the majority cardiac amyloidosis (CA), which have been considered mutually exclusive. Diagnostic confusion can arise when both proteins are identified from an amyloid deposit. We present a rare occurrence histopathologically confirmed concomitant ATTR AL CA captured on 99m Tc-3,3-diphosphono-1,2-propanodicarboxylic acid (DPD) scan 18 F-flutemetamol (FMM) PET/CT.
Sung-Soo Park, M.D., Ph.D., Na Yung Kim, M.S., Ji-Young Lim, Jung Yeon Lee, Sujin Yun, B.S., Yeun-Jun Chung, Seung-Hyun Jung, and Chang-Ki Min, Ph.D.. Ann Lab Med -0001;0:. https://doi.org/10.3343/alm.2024.0424
High-cost novel therapies for multiple myeloma (MM) require evaluation of efficacy and cost-effectiveness. This study developed a methodology to assess cost-effectiveness using nationwide data from 11,450 newly diagnosed MM patients. A algorithm was applied identify lines therapy (LoT). The number patients increased significantly, 873 in 2010 1,464 2019 (p<0.001). Advancing LoT associated with shorter time next treatment (TTNT) overall survival (OS) (p<0.001), while all-cause medical costs...
Abstract Human embryonic stem cell (hESC)‐derived dopaminergic (DA) neurons hold potential for treating Parkinson's disease (PD) through replacement therapy. Generation of DA from hESCs has been achieved by coculture with the stromal line PA6, a source cell‐derived inducing activity (SDIA). However, factors produced cells that result in SDIA are largely undefined. We previously reported medium conditioned PA6 can generate functional NTera2 human embryonal carcinoma cells. Here we show...
Previously, our group predicted commercially available Food and Drug Administration (FDA) approved drugs that can inhibit each step of the replication severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using a deep learning-based drug-target interaction model called Molecule Transformer-Drug Target Interaction (MT-DTI). Unfortunately, additional clinically significant treatment options since approval remdesivir are scarce. To overcome current disease 2019 (COVID-19) more...
The significance of Epstein-Barr virus (EBV) infections for the prognosis patients with peripheral T-cell lymphomas (PTCLs), specifically angioimmunoblastic lymphoma (AITL) and PTCL not otherwise specified (PTCL-NOS), remains unclear. encoding region can be used to detect EBV in tissue sections by situ hybridization (ISH) polymerase chain reaction (PCR) assays blood samples from PTCLs. This study compared outcomes AITL or PTCL-NOS whom presence infection was assessed these two methods.This a...
The sensitivity of Philadelphia chromosome (Ph)-positive acute lymphoblastic leukemia (ALL) to reduced-intensity conditioning (RIC) allogeneic hematopoietic cell transplantation (HCT) versus myeloablative (MAC) HCT by minimal residual disease (MRD) kinetics is not well established.This study compared long-term outcomes based on MRD for 79 patients with RIC transplants and 116 MAC in first complete remission (CR1) after tyrosine kinase inhibitor-based chemotherapy (median follow-up, 67.1...
Despite comparable outcomes of haploidentical transplants (Haplo-HSCT) with HLA-matched unrelated (MUD-HSCT) in retrospective comparisons, few studies have prospectively compared Haplo-HSCT MUD-HSCT AML. Here, we the for AML remission (n = 110) to prove non-inferiority overall survival Haplo-HSCT. Both groups were well balanced factors related biological features and measurable residual disease (MRD) status by Wilms' tumor gene 1 (WT1) assay. A unique, reduced-toxicity preparative regimen...
Abstract Background The data on the seasonality of respiratory viruses helps to ensure optimal vaccination period and monitor possible outbreaks variant type. Objectives This study was designed describe molecular epidemiology acute infection (ARI)‐related in United Arab Emirates (UAE). Methods Both upper lower specimens were collected for analysis from all patients who visited Sheikh Khalifa Specialty Hospital (SKSH) with ARI over 2 years. multiplex real‐time reverse transcription polymerase...
Recently we reported that transglutaminase 2 (TGase 2) activates nuclear factor-kappaB (NF-kappaB) independently of I-kappaB kinase (IKK) activation, by inducing cross-linking and protein polymer formation inhibitor factor-kappaBalpha (I-kappaBalpha). TGase catalyzes covalent isopeptide bond between the peptide bound-glutamine lysine residues. Using matrix-assisted laser desorption ionization time-of-flight mass spectra analysis I-kappaBalpha polymers cross-linked 2, as well synthetic...